Time Independent Viscoelastic Analysis Parameter for Prediction of Patient Outcome

ABSTRACT

In some embodiments, the invention provides an in vitro method for identifying a patient as likely as likely to require a transfusion of at least six units of blood in six hours or less. The method comprise, consists essentially of, or consists of (a) analyzing a sample of blood from a patient with a viscoelastic analysis assay to obtain a coagulation characteristic value that is independent of time of the patient; and (b) comparing the coagulation characteristic value of the patient to a coagulation characteristic value that is independent of time of a control, wherein the coagulation characteristic value of the patient that is lower than the coagulation characteristic value of the control identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. provisional patent application No. 62/172,535 filed Jun. 8, 2015 and to U.S. provisional patent application No. 62/172,951 filed Jun. 9, 2015, the entire contents of which are hereby incorporated by reference.

BACKGROUND OF THE INVENTION

The present invention relates to the fields of medicine and surgery, and emergent and chronic critical care for traumatic injury.

Following a traumatic injury (e.g., gunshot wound, car accident, or during surgery), uncontrolled hemorrhage (i.e., uncontrolled bleeding) is a leading cause of early death (Eastridge et al., J. of Trauma. 71(1 Suppl): S4-8, 2011; Gonzalez et al., J. of Trauma. 62(1):112-9, 2007; Kashuk et al., J. of Trauma 65(2):261-71, 2008). Trauma induced coagulopathy (TIC) is an exacerbating phenomenon observed in many cases of massive hemorrhage, and current practice emphasizes hemostatic resuscitation with blood components (Brohi et al., Current Opinion in Critical Care 13(6): 680-685, 2007; Brohi et al., Annals of Surgery 245(5): 812-818, 2007; Brohi et al., J. of Trauma, 64(5): 1211-1217, 2008; Cohen et al., Annals of Surgery 255(2): 379-385, 2012; Cotton et al., J. of Trauma and Acute Care Surgery 73(2):365-70, 2012; Dunn et al., Surg. Forum. 30:471-3, 1979). This practice is geared at not only replacing lost oxygen carrying capacity, but in reestablishing normal coagulation and forestalling the “bloody vicious cycle” of hemorrhagic shock, acidosis/hypothermia and coagulopathy (Kashuk et al., J. of Trauma 22(8):672-9, 1982; Cohen et al., Surg. Clin North Am. 92(4):877-91, 2012). Establishment, by hospital blood banks, of massive transfusion protocols (MTPs) to aid in efficient hemostatic resuscitation of patients with life-threatening hemorrhage, represents an important development in trauma systems management and has been shown to reduce mortality in massively bleeding patients.

Triggering a massive transfusion protocol (MTP) activation, however, is not without potentially negative consequences. Transfusion of blood or blood broducts consume large amounts of scarce medical resources (e.g. universal donor blood components either transfused or wasted) as well as exposing patients to the risks of transfusion of multiple units of blood products, empirically and potentially needlessly unless patients who truly require an MTP activation are chosen accurately (Johnson et al., Archives of Surgery 145(10):973-7, 2010; Moore et al., Archives of Surgery 132(6):620-4, 1997; Watson et al., J. of Trauma. 2009 August; 67(2):221-7; discussion 8-30, 2009; Neal et al., Archives of Surgery. 147(6):563-71, 2012).

Thus, there is a need to distinguish patients in massive hemorrhage who truly need a transfusion protocol from those patients who do not.

Viscoelastic analysis methods such as thrombelastography (TEG) and thromboelastometry (TEG) are robust and versatile diagnostic systems for point-of-care diagnosis of coagulopathy. However, application of these analysis methods in high acuity settings such as trauma and emergency surgery has been limited by the time it takes the test to yield a result with regard to clot strength, a key parameter for interpretation of the overall clotting performance of the patient's blood.

It would be useful to have rapid methods and parameters to accurately predict final clot strength and/or identify those patients who need transfusion of blood or blood products.

SUMMARY OF THE EMBODIMENTS

The invention provides new parameters from viscoelastic analyses of blood that are not dependent upon time.

In a first aspect, the invention provides an in vitro method for identifying a patient as likely to require a transfusion of at least six units of blood in six hours or less, the method comprising, consisting essentially of, or consisting of obtaining a coagulation characteristic value that is independent of time by using a viscoelastic analysis assay to analyze a sample of blood from the patient, wherein the coagulation characteristic value of the patient that is lower than a coagulation characteristic value that is independent of time of a control (such as a healthy volunteer) identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less.

In some embodiments, the coagulation characteristic value that is independent of time of a control is obtained by analyzing a sample of blood from the control with a viscoelastic analysis assay. In some embodiments, the the control is a healthy volunteer. In some embodiments, the control is a population of patients and the coagulation characteristic value of the control is the mean coagulation characteristic value of the population.

In some embodiments, the sample of blood is not supplemented with a clotting factor or an enhancer of clot formation. In some embodiments, the coagulation characteristic value that is independent of time is Acrit. In some embodiments, the coagulation characteristic value that is independent of time is dAmax.

In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than twenty minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value is obtained not more than fifteen minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than ten minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than fifteen minutes after the start of clot formation in the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than ten minutes after the start of clot formation in the sample of blood from the patient. In some embodiments, the coagulation characteristic value is obtained not more than five minutes after the start of clot formation in the sample of blood from the patient.

In some embodiments, the patient is human. In some embodiments, the patient is a trauma patient.

In some embodiments, the viscoelastic analysis assay is performed using a thromboelastography analyzer system. In some embodiments, the viscoelastic analysis assay is performed using a thromboelastometry analyzer system.

In some embodiments, the coagulation characteristic value that is independent of time of the patient that is at least 1.5 times lower than the coagulation characteristic value that is independent of time of the control (e.g., a healthy volunteer or a population of patients) identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less. In some embodiments, the coagulation characteristic value of the patient that is at least 1.5 times lower than the coagulation characteristic value of the control (e.g., a healthy volunteer or a population of patients) identifies the patient as likely to require a transfusion of at least ten units of blood in six hours or less.

In some embodiments, the coagulation characteristic value that is independent of time is obtained by fitting a tracing from the viscoelastic analysis assay of the same sample of blood from the patient to a tracing from the model dA/dT=aA²/(e^(bA)−1). In some embodiments, the coagulation characteristic value that is independent of time is obtained by taking an area under a tracing from the viscoelastic analysis assay of the same sample of blood from the patient from a start of clot formation to a maximum amplitude.

In another aspect, the invention provides an in vitro method for identifying a patient as likely as likely to require a transfusion of at least six units of blood in six hours or less, the method comprising, consisting essentially of, or consisting of (a) analyzing a sample of blood from a patient with a viscoelastic analysis assay to obtain a coagulation characteristic value that is independent of time of the patient; and (b) comparing the coagulation characteristic value of the patient to the coagulation characteristic value of the control, wherein the coagulation characteristic value of the patient that is lower than the coagulation characteristic value of the control (e.g., a healthy volunteer) identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less.

In some embodiments, the coagulation characteristic value that is independent of time of a control is obtained by analyzing a sample of blood from the control with a viscoelastic analysis assay. In some embodiments, the the control is a healthy volunteer. In some embodiments, the control is a population of patients and the coagulation characteristic value of the control is the mean coagulation characteristic value of the population.

In some embodiments, the sample of blood is not supplemented with a clotting factor or an enhancer of clot formation. In some embodiments, the coagulation characteristic value that is independent of time is Acrit. In some embodiments, the coagulation characteristic value that is independent of time is dAmax.

In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than twenty minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than fifteen minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value is obtained not more than ten minutes after the start of the viscoelastic analysis of the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than five minutes after the start of the viscoelastic analysis of the sample of blood from the patient.

In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than fifteen minutes after the start of clot formation in the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than ten minutes after the start of clot formation in the sample of blood from the patient. In some embodiments, the coagulation characteristic value that is independent of time is obtained not more than five minutes after the start of clot formation in the sample of blood from the patient.

In some embodiments, the patient is human. In some embodiments, the patient is a trauma patient.

In some embodiments, the viscoelastic analysis assay is performed using a thromboelastography analyzer system. In some embodiments, the viscoelastic analysis assay is performed using a thromboelastometry analyzer system.

In some embodiments, the coagulation characteristic value that is independent of time of the patient that is at least 1.5 times lower than the coagulation characteristic value that is independent of time of the control (e.g., a healthy volunteer or a population of patients) identifies the patient as likely to require a transfusion of at least six units of blood in six hours or less. In some embodiments, the coagulation characteristic value of the patient that is at least 1.5 times lower than the coagulation characteristic value of the control (e.g., a healthy volunteer or a population of patients) identifies the patient as likely to require a transfusion of at least ten units of blood in six hours or less.

In some embodiments, the coagulation characteristic value that is independent of time is obtained by fitting a tracing from the viscoelastic analysis assay of the same sample of blood from the patient to a tracing from the model dA/dT=aA²/(e^(bA)−1). In some embodiments, the coagulation characteristic value that is independent of time is obtained by taking an area under a tracing from the viscoelastic analysis assay of the same sample of blood from the patient from a start of clot formation to a maximum amplitude.

In yet another aspect, the invention provides an in vitro method for determining an amount of fibrinogen in a patient comprising: (a) obtaining a coagulation characteristic value that is independent of time of a sample of blood from the patient using a viscoelastic analysis assay and (b) plotting the patient coagulation characteristic value against a standard table of coagulation characteristic values of blood samples of healthy volunteers with known amounts of fibrinogen to determine the amount of fibrinogen in the sample of blood from the patient.

In some embodiments, the coagulation characteristic value that is independent of time is dAmax. In some embodiments, the patient is human.

In still another aspect, the invention provides an in vitro method for determining a quantity of platelets in a patient comprising: (a) obtaining a coagulation characteristic value that is independent of time of a sample of blood from the patient using a viscoelastic analysis assay and (b) plotting the patient coagulation characteristic value against a standard table of coagulation characteristic values of blood samples of healthy volunteers with known quantities of platelets to determine the quantity of platelets in the sample of blood from the patient.

In some embodiments, the coagulation characteristic value is a product of dAmax and Acrit. In some embodiments, the patient is human.

BRIEF DESCRIPTION OF THE DRAWINGS

The patent or application file contains at least one drawing executed in color. Copies of this patent or patent application publication with color drawing(s) will be provided by the Office upon request and payment of the necessary fee

The foregoing features of embodiments will be more readily understood by reference to the following detailed description, taken with reference to the accompanying drawings, in which:

FIG. 1 is a schematic diagram showing the clotting cascade that leads eventually to the formation of a blood clot. The contributions of the intrinsic and extrinsic pathway to the blood clot are shown.

FIG. 2A is a schematic diagram showing a thromboelastography (TEG) tracing or curve. As the upper and lower portions of the tracing are mirror images of each other, TEG tracings are sometimes depicted as just the upper half of the tracing. The time from assay initiation is the dependent variable (on the x-axis) and the amplitude of coupling of the motion of the reaction cup to a centrally suspended pin (a proxy for viscoelastic clot strength) is the readout variable, on the y-axis, as reported in FIG. 1A in units of millimeters. The events leading up to maximum amplitude (MA) of the clot are the clot formation stage, and following the MA is the clot dissolution stage or fibrinolysis stage.

FIG. 2B is a schematic diagram showing a TEG tracing from a healthy human volunteer. Note that in a healthy volunteer, fibrinolysis is very gradual.

FIG. 3 is a schematic diagram showing a thromboelastometry (TEM) tracing or curve. As the upper and lower portions of the tracing are mirror images of each other, TEM tracings are sometimes depicted as just the upper half of the tracing. The events leading up to maximum clot firmness (MCF) of the clot are the clot formation stage (or coagulation stage), and following the MA is the clot dissolution stage or fibrinolysis stage.

FIG. 4 is a schematic drawing showing a side-by-side comparison of a TEG tracing (top half of figure) and a TEM tracing (bottom half of figure). As is clear from FIG. 4, the R value in a TEG tracing is equivalent to a clotting time (CT) value in a TEM tracing, the K value in a TEG tracing is equivalent to a clot formation time (CFT) value in a TEM tracing, the MA value in a TEG tracing is equivalent to a MCF value in a TEM tracing.

FIGS. 5A and 5B are two TEM tracings. FIG. 5A is a TEM tracing in the presence of the EXTEM reagent, which allows assessment of clot formation, fibrin polymerization, and fibrinolysis via the extrinsic pathway. FIG. 5B is a TEM tracing the presence of the FIBTEM reagent, which blocks platelets. Thus, FIG. 5B shows an assessment of the clot firmness of a fibrin clot. As FIGS. 5A and 5B show, platelet and fibrinogen contribution to clot strength are not additive.

FIG. 5C is a schematic diagram showing a TEG tracing from a functional fibrinogen assay (green line) compared to the TEG tracing from a functional fibrinogen assay for a sample treated with tranexamic acid (TXA), an antifibrinolytic agent that blocks the action of plasminogen (blue line). As can be seen, in the presence of hyperfibrinolysis (as simulated by the addition of TXA) may obscure and lower the MA, as depicted in red parallel bars in FIG. 5C by the difference between the peaks of the green line and the blue line.

FIGS. 6A-6C is are variations of TEG tracings from a healthy human volunteer. FIG. 6A shows the classic TEG tracing. Note that this tracing in FIG. 6A is the upper half of the full TEG tracing, with amplitude (in mm) on the Y axis and time (in minutes) on the X axis. The point at which the amplitude is increasing most rapidly is depicted as the Acrit parameter. In FIG. 6A, the Acrit occurs when A (the amplitude) is 11.64. The derivative of this new parameter Acrit, namely dA, is 0.68. FIG. 6B is a curve showing the dA (derivative of amplitude) on the Y axis plotted against amplitude (in mm) on the Y axis. FIG. 6C shows the position of Acrit on the tracings of FIG. 6A and FIG. 6B. Thus, FIG. 6C shows that the Acrit parameter is when dA is 0.68 mm and A is 11.74 mm.

FIG. 6A is a TEG tracing from a healthy human volunteer (namely, patient no. 20074B). FIG. 6A shows the Acrit (with a dA at 0.66 and an A (amplitude) at 13.65 mm) which occurs at approximately 17.0 minutes. Additionally, FIG. 7A shows the split time (at t (time)=13.166667 minutes), A5 (at t=18.17 min and A=20.82 mm), A10 (at 5=23.17 min and A=43.18 mm, and Amax (i.e., the MA) at A=59.02 mm). In the patient shown in FIG. 7A, Amax occurs at approximately 42 minutes.

FIG. 7B is a line graph plotting dA/dT against amplitude for dA/dT=aA²/(e^(bA)−1) with coefficient a=0.011 and coefficient b=0.104 when A goes from 0 to 60.

FIG. 7C is a line graph plotting dA/dT against amplitude for dA/dT=aA²/(e^(bA)−1) with coefficient a=0.022 and coefficient b=0.104 when A goes from 0 to 60.

FIG. 7D is a line graph plotting dA/dT against amplitude for dA/dT=aA²/(e^(bA)−1) with coefficient a=0.011 and coefficient b=0.208 when A goes from 0 to 60.

FIG. 7E is a customized model line graph showing the a and b coefficients of patient 20074B (patient data shown as red squares) to create a custom model fitting the patient dA/dT data points against amplitude.

FIG. 8 is a dot plot, showing the dAmax plotted as a function of Acrit. The populations shown are healthy volunteers (light green triangles), trauma patients with negative significant hemorrhage (dark green squares), and trauma patients with massive hemorrhage (needing 10 units of blood in 6 hours, or dying of exsanguination in 6 hours) (orange diamonds).

FIG. 9 is a dot plot, showing the dAmax plotted as a function of Acrit. The populations shown are healthy volunteers (light green triangles), trauma patients with negative significant hemorrhage (dark green squares), trauma patients with significant hemorrhage (needing 6-10 units of blood in 6 hours) (yellow circles), and trauma patients with massive hemorrhage (needing 10 units of blood in 6 hours, or dying of exsanguination in 6 hours) (orange diamonds).

FIG. 10 is a histogram showing the area under the model curve at infinity. The area under the curve (AUC) from the split to the critical amplitude (i.e., the highest dA) is 5.39. Thus, the time-independent TEG AUC (TITAUC) is calculated in the amplitude domain and measures catalysis in the “launch phase” of clotting.

FIG. 11 is a line graph plotting the percent sensitivity versus the percent specificity for the receiver operating characteristic curve (ROC) of the time-independent TEG area under the curve (TITAUC) for patients with significant hemorrhage (i.e., trauma patients who need between 6 to 10 units of blood in 6 hours). As that data shows, quantitation of early catalysis predict those patients with significant hemorrhage.

FIG. 12 is a line graph plotting the percent sensitivity versus the percent specificity for the receiver operating characteristic curve (ROC) of the time-independent TEG area under the curve (TITAUC) for patients with massive hemorrhage (i.e., trauma patients who need at least 10 units of blood in 6 hours or less, or bleed to death within 6 hours). As that data shows, quantitation of early catalysis predict those patients with massive hemorrhage.

FIG. 13 is the tracing of the derivative of the amplitude of FIG. 7A fitted to the Amax curve (green line) and the Acrit curve (red line). As can be seen, with these two parameters, the fit is extremely close.

FIG. 14 is a scatter plot showing the convergence of the fit with increasing data, plotting time offset from Acrit (min) on the x-axis and normalize difference between model and empirical area (mm²) on the y-axis.

FIG. 15 is a fitting of the data to the model, even when the fit is only to Acrit. This yields the very simple prediction that MA is approximately equal to 15 (ln Q)+12 mm.

FIG. 16 is a scatter plot demonstrating sigmoid relation of dAmax to the amount of fibrinogen is a blood sample.

FIG. 17 is a scatter plot showing that a product of dAmax multiplied by Acrit (the “critical product”) is correlates linearly with the number of platelets in a blood sample.

FIG. 18 is a line graph showing receiver operating characteristic curve (ROC) of the time-independent TEG area under the curve (TITAUC) for patients with massive hemorrhage as compared to conventional TEG parameters. As can be see, the area under the curve (AUC) for time-independent TEG (blue line) has a higher identity for predicting massive hemorrhage than the AUC for MA (red line), the AUC for the alpha angle (purple line), the AUC for activated clotting time (ACT) (brown line) and the AUC for the International Normalization Ratio (INR) (green line).

DETAILED DESCRIPTION OF SPECIFIC EMBODIMENTS

The invention stems, in part, from the discovery of very rapid in vitro methods to reliably and accurately identify patients who are likely need a blood transfusion. The publications (including patent publications), web sites, company names, and scientific literature referred to herein establish the knowledge that is available to those with skill in the art and are hereby incorporated by reference in their entirety to the same extent as if each was specifically and individually indicated to be incorporated by reference. Any conflict between any reference cited herein and the specific teachings of this specification shall be resolved in favor of the latter.

The further aspects, advantages, and embodiments of the invention are described in more detail below. The definitions used in this specification and the accompanying claims shall following terms shall have the meanings indicated, unless the context clearly otherwise requires. Any conflict between an art-understood definition of a word or phrase and a definition of the word or phrase as specifically taught in this specification shall be resolved in favor of the latter. As used in this specification, the singular forms “a,” “an” and “the” specifically also encompass the plural forms of the terms to which they refer, unless the content clearly dictates otherwise. The term “about” is used herein to mean approximately, in the region of, roughly, or around. When the term “about” is used in conjunction with a numerical range, it modifies that range by extending the boundaries above and below the numerical values set forth. In general, the term “about” is used herein to modify a numerical value above and below the stated value by a variance of 20%.

Haemostasis is a tightly regulated process which causes bleeding to stop. In the body, circulating blood remains fluid under normal conditions, but forms localized clots when the integrity of the vascular system is breeched. Trauma, infection, and inflammation all activate the blood's clotting system, which depends on the interaction of two separate systems: enzymatic proteins in a clotting cascade (e.g., clotting factors such as Factor VII or Factor IX) and activated platelets. The two systems work in concert to plug defects in the broken vessels.

A blood clot (also called a thrombus) that forms during haemostasis is made of two parts—a platelet plug and a mesh of cross-linked fibrin protein. The fibrin results from cleavage of fibrinogen into fibrin by thrombin which is activated during the clotting cascade (see FIG. 1). A blood clot needs to be of sufficient strength to resist dislodgement by circulating blood or mechanical movement. If a particular clotting factor is dysfunctional or absent, as in hemophilia, an insufficient amount of fibrin forms. Similarly, massive consumption of clotting factors in a trauma situation decreases the amount of fibrin formed and can lead to uncontrolled hemorrhage. Inadequate numbers of platelets resulting from trauma, surgery, or chemotherapy also decrease platelet aggregation, as do genetic disorders, uremia, or salicylate therapy. Ultimately, reduced fibrin formation or platelet aggregation results in clots of inadequate tensile strength. This hypocoagulable state makes the patient prone to bleeding. Conversely, endothelial injury, stasis, cancer, genetic diseases, or other hypercoagulable states lead to thrombosis (i.e., blood clot) formation, exemplified in deep-vein thromboses, pulmonary emboli, and arterial occlusions such as stroke and myocardial infarction.

When a trauma patient is brought into a treatment center such as an emergency room, uncontrolled hemorrhage can lead to death. However, a recent analysis of data from a three year study of resuscitation strategies of patients (whose inclusion criteria included activation of an MTP) revealed that only 46% of patients, for whom an MTP was activated based upon the judgment of the attending trauma surgeon, actually went on to require a massive transfusion (defined as ≥10 units or packed red blood cells [PRBCs] in 6 hours). It is clear that clinician judgment leaves much to be desired in terms of accuracy of prediction of massive transfusion requirement. Additionally, recent experience with the design of several prospective trials related to trauma resuscitation have highlighted the difficulty in early, prospective selection of patients truly at high risk of major hemorrhage and coagulopathy (Brasel et al., Journal of the American College of Surgeons. 2008 February; 206(2):220-32, 2008; Bulger et al., Archives of surgery. 2008 February; 143(2):139-48; discussion 49); Bulger et al., Annals of surgery. 2011 March; 253(3):431-41; and Raab et al., Critical care medicine. 2008 November; 36(11 Suppl): S474-80).

Given the scarcity of donor blood (and blood products) and the potential risks associated from receiving a donor blood product (e.g., recipient immune response to the donor blood or recipient exposure to pathogens or contaminants in the donor blood), attempts have been made to develop new parameters, or repurpose existing parameters, in order to rapidly and accurately predict which patients are in need of a blood transfusion (e.g., with blood or a blood product). Such patients can be identified, for example, by determining clot strength of a blood sample taken from the patient.

Thus, in some embodiments, the invention provides in vitro methods for identifying a patient likely to suffer a massive hemorrhage (i.e., those patients who will require a transfusion of at least 10 units of blood in 6 hours or less, or who will bleed to death). In some embodiemtns, the method comprises obtaining a coagulation characteristic value that is independent of time using a viscoelastic analysis assay to analyze a sample of blood taken from the patient, wherein the coagulation characteristic value of the patient that is lower than a specified threshold (e.g., to some degree lower than that of a healthy volunteer or lower than the mean coagulation characteristic value of a population of patients) predicts that the patient is likely to suffer a massive hemorrhage. Early prediction of massive hemorrhage can be lifesaving as it allows the clinician to initiate massive transfusion protocol or other resuscitative interventions in a timely manner.

In some embodiments, the methodology described herein can be used to rapidly discriminate the origin of the coagulopathy leading to the massive hemorrhage as being with a defect in platelet or fibrinogen function.

The invention stems, in part, from the identification of a coagulation characteristic value derived from data obtained from analyzing patient blood samples using viscoelastic analyses. Such viscoelastic analyses include, without limitation, thromboelastography (TEG) and thromboelastometry (TEM).

As used herein, by “blood sample” or “sample of blood” is meant a sample of blood taken, for example, from a patient. The patient may be a human, but may also be any other animal (e.g., veterinary animal or exotic animal). Blood is the circulating tissue of an organism that carries oxygen and nutritive materials to the tissues and removes carbon dioxide and various metabolic products for excretion. Blood (often called whole blood) consists of a pale yellow or gray yellow fluid, plasma, in which are suspended red blood cells, white blood cells, and platelets. Some practitioners consider blood to be an organ. However, all agree that how quickly blood will clot is discernible from a sample of blood. It is a matter of analyzing the sample correctly to determine how the blood (e.g., cells and proteins in the blood) will clot. While current technology is limited by how quickly such information can be deduced from a sample of blood, in some embodiments, the present invention allows for such information to be obtained very quickly.

In some embodiments, as the term is used herein, by “blood” is meant whole blood, or a portion of whole blood, or a blood product (e.g., packed red blood cells). The blood in the blood sample taken from a patient (e.g., a trauma patient or a healthy volunteer) may thus be a sample of whole blood or a sample of a portion of blood or a sample of a blood product. The blood (e.g., blood in a blood sample) may be untreated, or may be treated. For example, a blood sample may be citrated blood (e.g., whole blood collected into a 3.5 mL container containing 3.2% citrate). The blood (e.g., blood in a blood sample) may also be a sample of platelet rich plasma. The blood (e.g., blood in a blood sample) may also be heparinized blood or may be a blood sample treated with protamine to reverse the effects of heparin. In some embodiments, the blood sample is not supplemented with a clotting factor (e.g., thrombin) and/or is not supplemented with an enhancer of clot formation (e.g., kaolin). The blood (e.g., blood in a blood sample) may be fresh, frozen, or stored according to standard methods (e.g., stored at 4° C. in a blood storage solution such as the storage solution described in U.S. Pat. No. 8,709,707). Thus, whenblood refers to one or more components of whole blood, any of these components may be treated. Thus, blood (e.g., blood in a blood sample) may be platelets, packed red blood cells, heparinized packed red blood cells, citrated blood, plasma or platelet-free plasma taken from the blood of the patient. In some embodiments, the blood (e.g., blood in a blood sample) may be a sample that has reduced platelet function. For example, the blood (e.g., blood in a blood sample) may be treated with an inhibitor of platelet function such as cytochalasin D.

Note that by “blood transfusion” or simply “transfusion” is meant administration (e.g., by intravenous route) of blood (as defined above) to a recipient patient. The blood transfused to the patient can be fresh, or frozen, and can be whole blood, citrated blood, packed red blood cells, platelets, and so forth. Typically, blood is administered in units, where one unit of blood is roughly equal to one pint of whole blood. Note that the unit of blood may be a unit of packed red blood cells, but that unit of packed red blood cells is still equivalent to approximately one pint of whole blood for the donor. In some embodiments, the transfusion given to the patient is matched to the patient's ABO profile (e.g., O type blood donated to A patient, B patient, or AB patient, or B type blood donated to B or AB patient).

By “viscoelastic analysis” or “viscoelastic analysis assay” is meant any in vitro analysis method that measures the characteristics of elastic solid (e.g., fibrin solids) and fluids. In other words, viscoelastic analysis allows the study of properties of a viscous fluid, such as blood or a blood sample taken from a patient (e.g., a human patient). By using viscoelastic analysis, the mechanical strength of an evolving blood clot can be measured in vitro.

In some embodiments, the viscoelastic analysis is performed under conditions that mimic the conditions in vivo that govern hemostasis. Hemostasis is a tightly regulated, extremely complex process involving many interacting factors, which include coagulation and fibrinolytic proteins, activators, inhibitors and cellular elements, such as platelet cytoskeleton, platelet cytoplasmic granules and platelet cell surfaces, that controls bleeding in the body of an individual (e.g., a human individual). Hemostasis includes and comprises the balance between two processes: (1) the coagulation process, namely blood coagulation by formation of a fibrin-containing blood clot, and (2) the fibrinolysis process, namely the process involved in the breakdown of that clot, for example, by activation of plasmin to dissolve the fibrin mesh holding the clot together.

For example, the condition may include a temperature that mimics a body temperature (e.g., a temperature of 37° C.). The condition may also include clot formation and dissolution at flow rates that mimic those found in blood vessels.

Various devices that perform thromboelastography, and methods for using these devices, are described in U.S. Pat. Nos. 5,223,227; 6,225,126; 6,537,819; 7,182,913; 6,613,573; 6,787,363; 7,179,652; 7,732,213, 8,008,086; 7,754,489; 7,939,329; 8,076,144; 6,797,419; 6,890,299; 7,524,670; 7,811,792; 20070092405; 20070059840; U.S. Pat. No. 8,421,458; US 20120301967; and U.S. Pat. No. 7,261,861, the entire disclosures of each of which are hereby expressly incorporated herein by reference.

Thromboelastography (TE) monitors the elastic properties of blood as it is induced to clot under a low shear environment resembling sluggish venous blood flow. The patterns of changes in shear elasticity of the developing clot enable the determination of the kinetics of clot formation, as well as the strength and stability of the formed clot; in short, the mechanical properties of the developing clot. As described above, the kinetics, strength and stability of the clot provides information about the ability of the clot to perform “mechanical work,” i.e., resisting the deforming shear stress of the circulating blood. In essence, the clot is the elementary machine of hemostasis. Hemostasis instruments that measure hemostasis are able to measure the ability of the clot to perform mechanical work throughout its structural development. These hemostasis analyzers measure continuously all phases of patient hemostasis as a net product of whole blood components in a non-isolated, or static fashion from the time of test initiation until initial fibrin formation, through clot rate strengthening and ultimately clot strength through clot lysis.

In some embodiments, the viscoelastic analysis and/or the hemostais analyzer comprises a container which is in contact with the blood.

As used herein, by “container” is meant a rigid surface (e.g., a solid surface), a portion of which contacts a portion of a blood sample placed into the container at any point during the viscoelastic analysis. The portion of the container that contact the portion of blood sample may also be referred to as the “interior” of the container. Note that the phase “into the container” does not mean that the container has a bottom surface which is in contact with the portion of the blood sample. Rather, the container can be a ring-shaped structure, where the inside of the ring is the interior of the container, meaning that the inside of the ring is the portion of the ring-shaped container that contacts a portion of the blood sample. A blood sample can flow into the container and be held there, for example, by vacuum pressure or surface tension.

Still additional types of containers that are included in this definition are those present on plates and cassettes (e.g., a microfluidic cassette), where the plate or cassette has multiple channels, reservoirs, tunnels, and rings therein. Each of the contiguous channels (comprising, for example, a channel, a reservoir, and a ring) is a container, as the term is used herein. Hence, there may be multiple containers on one cassette. U.S. Pat. No. 7,261,861 (incorporated herein by reference) describes such a cassette with multiple channels or containers. Any of the surfaces in any of the channels or tunnels of the cassette may be an interior of the container if that surface comes into contact with any portion of the blood sample, at any time during the viscoelastic analysis.

Additional non-limiting hemostasis analyzer instruments are described in U.S. Pat. No. 7,261,861; US Patent Publication No. US20070092405; and US Patent Publication No. US20070059840.

A non-limiting analyzer instrument that performs viscoelastic analysis using thromboelastography is the TEG thromboelastograph hemostasis analyzer system sold commercially by Haemonetics, Corp. (Braintree, Mass.).

Thus, the TEG assay may be performed using the TEG thromboelastograph hemostasis analyzer system that measures the mechanical strength of an evolving blood cloth. To run the assay, the blood sample is placed into a container (e.g., a cup or a cuvette), and a metal pin goes into the center of the container. Contact with the interior walls of the container (or addition of a clot activator to the container) initiates clot formation. The TEG thromboelastograph hemostasis analyzer then rotates the container in an oscillating fashion, approximately 4.45 degrees to 4.75 degrees, every 10 seconds, to imitate sluggish venous flow and activate coagulation. As fibrin and platelet aggregates form, they connect the inside of the container with the metal pin, transferring the energy used to move the container in the pin. A torsion wire connected to the pin measures the strength of the clot over time, with the magnitude of the output directly proportional to the strength of the clot. As the strength of the clot increases over time, a classic TEG tracing curve develops (See FIG. 2A, where clot strength is reflected on the Y axis and time is on the X axis).

Where there is a pin in the TEG analyzer, the rotational movement of the pin is converted by a transducer to an electrical signal, which can be monitored by a computer including a processor and a control program. The computer is operable on the electrical signal to create a hemostasis profile corresponding to the measured clotting process. Additionally, the computer may include a visual display or be coupled to a printer to provide a visual representation of the hemostasis profile. Such a configuration of the computer is well within the skills of one having ordinary skill in the art. As shown in FIG. 2A, the resulting hemostasis profile (i.e., a TEG tracing curve) is a measure of the time it takes for the first fibrin strand to be formed, the kinetics of clot formation, the strength of the clot (measured in millimeters (mm) and converted to shear elasticity units of dyn/cm 2) and dissolution of clot. See also Donahue et al., J. Veterinary Emergency and Critical Care:15(1): 9-16. (March 2005), herein incorporated by reference

The descriptions for several of these measured parameters shown in FIG. 2A are well known and have been described elsewhere (see, e.g., Kouerinis et al., Interactive Cardiovascular and Thoracic Surgery 7: 560-563, 2008; Walsh et al., J. of Extracorporeal Tech. 43(3): 162-167, 2011; and Galvez and Cortes, Revista Colombiana Anestesiol. 40: 224-230, 2012; all incorporated by reference herein in their entireties).

Briefly, ACT (or R) is the time is the period of time of latency from the time that the blood sample is placed in the TEG analyzer until the initial clot formation. This is typically takes about 4-8 minutes in a healthy person. For patients in a hypocoagulable state (i.e., a state of decreased coagulability of blood), the ACT (or R) number is longer (i.e., higher), while in a hypercoagulable state (i.e., a state of increased coagulability of blood), the ACT (or R) number is shorter.

K value (measured in minutes) is the time from the end of ACT until the clot reaches 20 mm. The K value represents the speed of clot formation. This K value is about 0 to about 4 minutes (i.e., after the end of ACT) in a healthy person. In a hypocoagulable state, the K number is longer, while in a hypercoagulable state, the K number is shorter.

α measures the rapidity of fibrin build-up and cross-linking (clot strengthening). Thus, it shows the rate at which a solid clot is formed. It is angle between the line formed from the split point tangent to the curve and the horizontal axis, and represents the kinetics of clot development. This angle is typically about 47° to 74°. In a hypocoagulable state, the a degree is lower, while in a hypercoagulable state, the α degree is higher.

MA or Maximum Amplitude in mm, is a direct function of the maximum dynamic properties of fibrin and platelet bonding and represents the ultimate or maximum strength of the clot. The MA number (also referred to herein as Amax) is the greatest diameter of the clot and a measure of the clot's elasticity. This number is typically from about 54 mm to about 72 mm in a normal individual, and the MA occurs typically between about 15 to about 35 minutes after the start of the viscoelastic assay. Note that if the blood sample tested has a reduced platelet function, this MA represents the strength of the clot based on fibrin only. Decreases in MA may reflect a hypocoagulable state (e.g., with platelet dysfunction or thrombocytopenia), whereas an increased MA (e.g., coupled with decreased R) may be suggestive of a hypercoagulable state.

LY30 measures the rate of amplitude reduction 30 minutes after MA and represents clot retraction, or lysis. The LY30 is, therefore, the percentage of lysis of the clot or a percentage decrease in amplitude 30 minutes after the MA. The LY30 can also be described as the loss of potential area of under the TEG curve. For example, if the amplitude of the curve did not decrease following the peak at MA, the LY30 would be 0%. In healthy individuals, this LY30 number is typically 0% to about 8% (see FIG. 2B). In some embodiments, a hypocoagulable state is present if the LY30 is greater than 7.5%. In some embodiments, an LY30 that is greater than 6%, or greater than about 5%, or greater than about 4%, or greater than about 3.5%, or greater than about 3% identifies a patient with a hypocoagulable state.

Another viscoelastic hemostasis assay that can be used is the thromboelastometry (“TEM”) assay. This TEM assay may be performed using the ROTEM Thromboelastometry Coagulation Analyzer (TEM International GmbH Munich, Germany), the use of which is well known (See, e.g., Sorensen, B., et al., J. Thromb. Haemost., 2003, 1(3): p. 551-8. Ingerslev, J., et al., Haemophilia. 2003. 9(4): p. 348-52. Fenger-Eriksen, C., et al. Br J Anaesth, 2005. 94(3): p. 324-9]. In the ROTEM analyzer, the blood sample is placed into a container (also called a cuvette or cup) and a cylindrical pin is immersed. Between pin and the interior wall of the container there is a gap of 1 mm which is bridged by the blood. The pin is rotated by a spring to the right and the left. As long as the blood is liquid (i.e., unclotted), the movement is unrestricted. However, when the blood starts clotting, the clot increasingly restricts the rotation of the pin with rising clot firmness. The pin is connected to an optical detector. This kinetic is detected mechanically and calculated by an integrated computer to the typical tracing curves (TEMogram) and numerical parameters (see FIG. 3).

In the ROTEM Thromboelastometry Coagulation Analyzer, the movement of the pin can be monitored by a computer including a processor and a control program. The computer is operable on the electrical signal to create a hemostasis profile corresponding to the measured clotting process. Additionally, the computer may include a visual display or be coupled to a printer to provide a visual representation of the hemostasis profile (called a TEMogram. Such a configuration of the computer is well within the skills of one having ordinary skill in the art. As shown in FIG. 3, the resulting hemostasis profile (i.e., a TEM tracing curve) is a measure of the time it takes for the first fibrin strand to be formed, the kinetics of clot formation, the strength of the clot (measured in millimeters (mm) and converted to shear elasticity units of dyn/cm 2) and dissolution of clot. The descriptions for several of these measured parameters are as follows:

CT (clotting time) is the period of time of latency from the time that the blood was placed in the ROTEM analyzer until the clot begins to form. In some embodiments, the CT time is the period of time from when the blood is placed on the ROTEM analyzer to when the amplitude reaches 1 mm wide.

CFT (Clot formation time): the time from CT until a clot firmness of 20 mm point has been reached. In FIG. 3, this CFT time is depicted as the time immediately following CT. CFT is reflective of the speed of clot formation.

alpha-angle: The alpha angle is the angle measured between the midline of the tracing and a line drawn from the 1 mm point tangential to the curve. This parameter is reflective of the speed of clot formation.

MCF (Maximum clot firmness): MCF is the greatest vertical amplitude of the trace. MCF reflects the absolute strength of the fibrin and platelet clot.

A10 (or A5, A15 or A20 value). This value describes the clot firmness (or amplitude) obtained after 10 (or 5 or 15 or 20) minutes after the clotting time (CT). In other words, and provide a forecast on the expected MCF value at an early stage.

LI 30 (Lysis Index after 30 minutes). The LI30 value is the percentage of remaining clot stability in relation to the MCF value at 30 min after CT.

ML (Maximum Lysis). The ML parameter describes the percentage of lost clot stability (relative to MCF, in %) viewed at any selected time point or when the test has been stopped.

A low LI 30 value or a high ML value indicates hyperfibrinolysis. While in normal blood fibrinolysis activity is quite low, in clinical samples a more rapid loss of clot stability by hyperfibrinolysis may lead to bleeding complications which can be treated by the administration of antifibrinolytic drugs.

Thus, parameters of interest in TEG or TEM assays include the maximum strength of the clot which is a reflection of clot strength. This is the MA value in the TEG assay, and the MCF value in the TEM assay. The reaction time (R) in TEG (measured in sec) and clotting time (CT) in TEG is the time until there is first evidence of clot; clot kinetics (K, measured in minutes) is a parameter in the TEG test indicating the achievement of clot firmness; and α in TEG or alpha-angle in TEM is an angular measurement from a tangent line drawn to the curve of the TEG tracing or TEM tracing starting from the point of clot reaction time that is reflective of the kinetics of clot development. (See Trapani, L. M. Thromboelastography: Current Applications, Future Directions”, Open Journal of Anesthesiology 3(1): Article ID: 27628, 5 pages (2013); and Kroll, M. H., “Thromboelastography: Theory and Practice in Measuring Hemostasis,” Clinical Laboratory News: Thromboelastography 36(12), December 2010; instruction manuals for the TEG instrument (available from Haemonetics, Corp.), and the instruction manual for the ROTEM instrument (available from TEM International GmbH), all of which documents are herein incorporated by reference in their entireties.

In some embodiments, the parameters (and hence the coagulation characteristics) are recorded by observation of different excitation levels of the sample as coagulation occurs. For example, where the container is a microfluidic cassette, or a particular channel in the cassette, the blood sample may be excited at a resonant frequency and its behavior observed by an electromagnetic or light source as coagulation occurs. In other embodiments the sample's coagulation characteristics may be observed for changes with a light source without exciting the sample.

Because a single cassette may have multiple containers (e.g., different channels in the cassette), the sample in a container contacted with an inhibitor of fibrinolysis is easily directly comparable to a sample in a container (e.g., in an adjacent channel in the same microfluidic cassette) that is not contacted with the inhibitor of fibrinolysis.

When no fibrinolysis occurs, the amplitude value at the MA on a TEG tracing and the amplitude value at the MCF on a TEM tracing stays constant or may decrease slightly due to clot retraction. However, as fibrinolysis occurs (e.g., in a hypocoagulable state), the curve of the TEG tracing and the TEM tracing starts to decay. The resultant loss in potential area-under-the-curve in the 30 minutes following Maximum Amplitude in the TEG assay is called the LY30 (see FIG. 2A). LY30, the percentage of lysis 30 minutes after the maximum amplitude point (expressed as a percentage of the clot lysed) and clot firmness (G, measured in dynes/cm²), indicates the rate of clot lysis. The corresponding value in the TEM assay is the LI30 value (see FIG. 3).

The LY30 is the usual metric of fibrinolysis. However, this parameter has some limitations including lack of sensitivity and specificity. Most importantly, the LY30 parameter takes at least 30 minutes to obtain. In normal patients, obtaining the LY30 in at least thirty minutes (because the 30 minutes must be added to whatever the time it took the clot to form in the first place) is adequate. However, in trauma patients, waiting the at least 30 minutes to determine if the patient's blood is clotting normally may be detrimental to the patient's outcome (e.g., the patient may bleed to death).

Thus, viscoelastic assays such as TEG and TEM measure the mechanical strength of the evolving blood clot over time. As the strength of the blood clot increases over time, a classic TEG curve (FIG. 2A) or classic TEM curve (see FIG. 3) develops. FIG. 4 provides a convenient side by side comparison of the TEG curves (upper part of the figure from a TEG apparatus) and TEM curves (lower part of the figure from a ROTEM apparatus). Note that for both TEG and TEM, sometimes only the upper half of the curve is depicted (see, for example, the TEG curve depicted in FIG. 7A).

There are, however, drawbacks to using the standard TEG and TEM assays. For example, it is difficult to measure the contributions of platelets and fibrinogen to the clot. Currently, the assays such as EXTEM and platelet-inhibitor containing FIBTEM (see FIGS. 5A and 5B, respectively) are run to try to determine the contributions of platelets and fibrinogen to clot strength. However, simple subtraction of assays run with and without platelet inhibitors is not an accurate measure of the contributions of platelets and fibrinogen because as FIGS. 5A and 5B show, platelet and fibrinogen contribution to clot strength is not additive.

Furthermore, perhaps the biggest drawback of all of the above listed parameters of TEG and TEM is the amount of time needed to obtain them. For example, while the MA (or MCF) and the LY30 (or LI30) in TEG and the MCF in TEM are considered two of the more important measurements of the clot in their respective assays, they are by definition obtainable only after the assay has been running for some time. For example, the LY30 and LI30 parameters are obtainable thirty minutes after the MA or MCF which, themselves, are obtainable after the R/ACT time and K time in the TEG assay, and after the CT time and the CFT time in the TEM assay. In the healthy volunteer whose data is depicted in FIG. 7A, Amax (i.e., MA) is not obtainable until 42 minutes after the start of the TEG analysis. During treatment of an individual with a traumatic injury (e.g., a person who has been in a car accident), minutes can make the difference between a positive outcome and a negative one.

Additionally, as FIG. 5C shows, if the patient has hyperfibrinolysis, an accurate reading of MA may be impossible. In this FIG. 5C, the antifibrinolytic agent tranexamic acid (TXA) is added to a blood sample to simulate a hyperfibrinolytic condition. As FIG. 3C shows, the true MA (i.e., Amax) is never reached in the hyperfibrinolysis sample, because the clot starts breaking down too soon. Yet accurate reading of the MA is very important for determining patient outcome.

The invention therefore stems, in part, from the desire to develop parameters that predict MA on a rational physical basis and encompass enough of the early TEG tracing to accurately predict its future trajectory. Results of earlier observational studies indicated that a major source of noisiness in the predictive value of early TEG parameters was the position of the parameters with respect to time as the dependent variable. As the rate of clot formation feeds back into the independent variable, the TEG curve shape is difficult to model over a wide dynamic range. Moreover, the inherent physics of clot formation are in essence time independent but are describable by the instantaneous state of the clot structure and concentration of the catalytic and stoichiometric participants in clot formation.

Thus, in some embodiments, the invention provides a model of clot formation in a time-independent domain, wherein TEG amplitude (A) is a proxy for clot strength and thus instantaneous clot structure and the instantaneous rate of clot formation at that state (dA/dT) becomes the dependent variable, such that:

dA/dT=f(A)

This function clearly defines the “accelerative” versus “coasting” phases of clot formation, a novel reconstitution of the traditional notions of initiation versus propagation in a non-temporal domain.

The implied function dA/dT=f(A) is then modeled using a physical model that bore a resemblance to the data derived from the human healthy volunteers. That physical model is:

dA/dT=aA ²/(e ^(bA)−1)

which is a lower order modification of Planck's equation which contains only two fitting coefficients, namely a and b. Note that the values for a and b will vary in each patient. The values for a and b are how the fitting is done.

In some embodiments, A is the value of the Amplitude, e is a mathematical constant that is approximately 2.71828, a is a patient-specific coefficient derived from fitting that patient's data to the empirically derived equation using a least squares method (a well-established data fitting method), and b is also a patient-specific coefficient derived from fitting that patient's data to the empirically derived equation using a least squares method. In some embodiments, coefficient a=0.011 and coefficient b=0.104. In some embodiments, A goes from 0 to 60.

The invention, in some embodiments, therefore provides time-independent parameters. One such parameter is dAmax for the maximum in the rate of change of A. Thus, just as MA is the maximum amplitude is the time-domain TEG curve (see, e.g., FIG. 1A), the global maximum in the time independent TEG curve is dAmax. Note that “Amax” and “MA” are interchangeable terms and both refer to the maximum amplitude. The corresponding amplitude of dAmax called the critical amplitude or Acrit. In taking a derivative of the TEG curve, the derivative of Acrit appears at the peak of a curve plotting dA versus amplitude (in mm). Acrit occurs when dA is at its maximum value (i.e., Acrit occurs at dAmax). See, for example, FIG. 6C.

Accordingly, in a first aspect, the invention provides a method for identifying a patient likely to require a transfusion of at least six units of blood in six hours, the method comprising obtaining a coagulation characteristic value that is independent of time by using a viscoelastic analysis assay to analyze a sample of blood from the patient, the coagulation characteristic value obtained not more than fifteen minutes after the start of clot formation in the sample of blood from the patient, wherein the coagulation characteristic value of the patient that is lower than the coagulation characteristic value that is independent of time of a control (e.g., a healthy volunteer) identifies the patient as likely to require a transfusion of at least six units of blood in six hours.

The invention stems, in part, from the development of the model

dA/dT=f(A)

which is based on taking the derivative of the TEG amplitude (A) parameter over the derivative of Time such that the function f(A) is arrived at. The modeling of this f(A) function allows the prediction of the maximal value of A (MA) based upon the trajectory during the accelerative phase of clot formation.

In some embodiments, the examples below describe the development of this model for f(A).

Thus, in some embodiments, the term “coagulation characteristic value” is meant any value obtained from viscoelastic analysis (e.g., maximum amplitude, LY30, A15).

One non-limiting coagulation characteristic value is Acrit, namely the point at which the rate of change of amplitude is at the maximum. In other words, Acrit is the amplitude at dAmax. Note that Acrit is not the same as MA (or Amax) because just as a moving vehicle does not immediately come to a halt once it stops accelerating, so too the amplitude does not immediately start declining once the rate of change of amplitude stops accelerating.

In some embodiments, the Acrit is obtained at least 10 minutes before the MA is obtained. In some embodiments, the Acrit is obtained at least 15 minutes before the MA is obtained.

As described below, in the examples, the blood of healthy volunteers have fairly high Acrit and modest dAmax. Patients who have significant hemorrhage (i.e., need 6 to 10 units of blood transfused in 6 hours) or massive hemorrhage have lower Acrit than the healthy volunteers. Patients who are injured (e.g., trauma patients) but who do not need more than 6 units of blood transfusion in 6 hours have moderate Acrit but high dAmax.

It should be noted that blood sample of the patient that is being analyzed should be kept on the viscoelastography analyzer, even after the Acrit parameter is taken.

Thus, in some embodiments, the invention uses information based on mathematical analysis of data emitting from a viscoelastic assay device (e.g., a thromboelastograph or a thromboelastometer) to predict whether a patient will require a blood transfusion.

In Example I below, an explanation of the mathematical derivation of Acrit and dAmax is described. Examples II-V describe working embodiments on healthy human volunteers and human patients (e.g., trauma patients).

Example I

In this Example I, a thromboelastoograph (TEG) device commercially obtained from Haemonetics, Corp. (Braintree, Mass.) is used.

Thromboelastography (TEG) is a diagnostic procedure that uses a thin wire probe to measure the strength of blood clots. This measurement is obtained by rotating a sample of blood around the thin wire probe. As the TEG machine rotates the blood, blood clots form and the wire probe adheres to the clot. When the wire probe adheres to the clot, it begins to move with the clot. The movement of the wire probe is recorded as an amplitude in millimeters. Therefore, a patient's clotting ability is directly related to the measured maximum amplitude. Understanding a patient's clotting ability is especially desirable in emergency trauma settings. Disclosed herein is the surprising discovery that the maximum amplitude can be accurately modeled in less time than it takes to measure the maximum amplitude. This can be done by measuring data to a point known as the critical amplitude and deriving the maximum amplitude from this data. An example of data obtained using TEG on a real patient sample is shown in FIG. 7A.

FIG. 7A shows a TEG curve for a healthy human volunteer, namely patient 20074B. As can be seen from FIG. 7A, the amplitude at time t=0 min until t=13.16 min is 0 mm. This is because the blood has not sufficiently clotted to adhere to the wire probe until the split at t=13.16 minutes. Until clotting forms, the wire probe remains motionless, and thus the amplitude is 0. In the art, this period of 0 amplitude may be known as the reaction time or “R value.” As the blood sample begins to clot, the wire probe adheres to the moving blood sample and starts moving. As the wire probe moves, the amplitude becomes non-zero.

The amplitude of the wire probe's motion is directly proportional to the strength of the clot. The Amax value is an important factor of a TEG analysis because it indicates the strength of the blood clot i.e., the overall stability of the clot. A computer may record and store the amplitude data as it is collected. The frequency with which amplitude data measurements are taken or sampled is known as the “sampling rate.” The sampling rate is easily modified by one having skill in the art, and frequently is a changeable parameter that is part of the data collection software. However, during a single set of data collection, a constant sampling rate is preferable. In other words, the time elapsing between measurements (τ) is preferably consistent. For example, the sample rate may be per minute, every second (hertz) or every millisecond (kHz), based on the number of data points and specificity desired. The sample rate may be limited by the maximum sample rate of the device. Alternatively, the sample rate may be dictated by the amount of data that we want to collect. Realistically, time measurements on the plot are shown to fractions of a minute. For example, a split point where the clot starts to form can be measured to t=13.166667 min. The time scale accuracy shows that the sample rate may be fractions of a second.

As data points are collected, it is possible to obtain the rate of change of amplitude (dA/dT). The collection of amplitude data points may be conceptualized as follows:

Amplitude data=[A₀, A₁, A₂, A₃, . . . , A_(N−1), A_(N)] where A₁ is the first amplitude data point collected, A₂ is the second amplitude data point collected and so on until N data points have been collected. In this case A₀ is the baseline amplitude immediately prior to data collection, e.g. 0.

Each amplitude data point is taken at a corresponding time interval.

Time data=[T ₀ ,T ₁ ,T ₂ ,T ₃ , . . . T _(N−1) ,T _(N)]

Because we can assume that the sampling rate is consistent throughout the entire period of data collection, it should be understood that the time between each measured sample is consistent. Specifically,

τ=T ₁ −T ₀ =T ₂ −T ₁ =T ₃ −T ₂ =T _(N) −T _(N−1)

In other words, if one records 5 samples per second over the course of 30 seconds, 150 data points are obtained with ⅕th of a second between each data point. It should be understood that the time units are dependent upon the sample rate chosen (amplitude values may be collected every millisecond, every second, every minute, etc.).

The rate of change of amplitude per time (dA/dT) for any N-th data point may be conceptualized as follows:

$\frac{{dA}_{N}}{dT} = \left\lbrack \frac{A_{N} - A_{N - 1}}{T_{N} - T_{N - 1}} \right\rbrack$

When sampling rate is consistent, the denominator is the same in every equation because the time intervals between all measurements are the same as a result of a consistent sampling rate. The rate of change of amplitude per time (dA/dt) for any N-th data point may be simplified as follows:

$\frac{{dA}_{N}}{dT} = \left\lbrack \frac{A_{N} - A_{N - 1}}{\tau} \right\rbrack$

where τ is a constant equal to the inverse of the sampling rate, i.e. the time between sampling.

Thus, the parameter dA_(N)/dT is independent of time.

As shown in FIG. 7A, amplitude rapidly increases after the “split.” The rate of change of the amplitude continues to increase until a point labeled Acrit. At Acrit, amplitude increases at the fastest rate. After Acrit, amplitude continues to ascend, but at a slower rate than at Acrit. As the rate of change is calculated over the course of data collection by the computer, it is possible to identify at what time the maximum rate of change (Acrit) occurs. For example, rate of change (dA/dT) values will continue to increase until a maximum rate of change is reached (Acrit), and then rate of change (dA/dT) will decrease. However, just because the rate of change (dA/dT) decreases, it should be noted that amplitude may still be increasing, albeit at a slower rate. A routinely skilled practitioner can review the data emitting from the TEG analysis of a blood sample and detect Acrit, the point at which the rate of change of A stops accelerating and starts slowing down. Of course, a computer can detect that the maximum rate of change (dA/dT) has occurred and identify point Acrit as it occurs.

The amplitude eventually reaches a maximum value, shown as Amax on FIG. 7A. This Amax value provides valuable diagnostic data about the strength of the clot and is also referred to as maximum amplitude (MA) or maximum clot firmness (MCF). In healthy patients, fibrinolysis occurs after Amax, as the wire probe begins to slip, resulting in an amplitude decrease as shown.

In FIG. 7A, Amax occurs approximately 42 minutes after starting the thromboelastography analysis (i.e., putting the blood sample into the TEG machine). The Amax value is approximately 59.02 mm. Because Amax dictates blood clot strength as well as other physiological parameters, in certain emergency patient care situations the sooner Amax can be determined the better. Thus in emergency trauma settings, it is desirable to determine the value for Amax well before the 42 minutes required to reach Amax. As discussed below in Example II, the health and well-being of a trauma patient is assessed at six hours. Therefore, 42 minutes is a very long time to have to wait to determine patient outcome.

Thus, embodiments of the present invention use an empirically derived equation to model Amax from values of Acrit. As a result, Amax (i.e., MA) can be estimated within an accuracy level appropriate to determine relevant physiological factors at the time of Acrit, approximately half the time required to measure Amax.

In some embodiments of the invention, a computer may record amplitude and dA/dT data as discussed above in real time. The data collection may, for example, look something like Table 1 below.

TABLE 1 dA/dT Amplitude (mm/time (mm) unit) 10 0.60135 11 0.622166 12 0.637843 13 0.648832 14 0.655564 15 0.658451 (A_(crit)) 16 0.657884

As can be seen, when the Amplitude is 15 mm, the rate of change (dA/dT) has reached its maximum (Acrit) at 0.658451 mm/time unit. When the Amplitude is 16 mm, dA/dT begins to descend (note that Amplitude does not descend, only its rate of change (dA/dT) has slowed). In FIG. 7A, Acrit occurs when Amplitude reaches 15 mm at approximately 17 minutes. That is all the time and data that needs to be collected to obtain a calculated Amax using the empirically derived equation described below. As should be understood, obtaining an Amax value from an Acrit value provides a substantial benefit in terms of the time necessary to obtain a value for Amax.

In accordance with the present invention, the inventors have discovered that patient data collected from 161 healthy volunteers could be modeled with empirically derived equation: dA/dT=aA²/(e^(bA)−1) This equation represents the derivative, or rate of change, of the Amplitude in respect to time. A is the value of the Amplitude, e is a mathematical constant that is approximately 2.71828, a is a patient-specific coefficient derived from fitting that patient's data to the empirically derived equation using a least squares method (a well-established data fitting method), and b is also a patient-specific coefficient derived from fitting that patient's data to the empirically derived equation using a least squares method. To accurately model dA/dT, in some embodiments, the data is collected all the way to point Acrit. After Acrit, the dA/dT equation can be solved for the missing coefficients a and b by a computer in seconds.

FIG. 7B is a graph of dA/dT=aA²/(e^(bA)−1) with coefficient a=0.011 and coefficient b=0.104 when A goes from 0 to 60:

Theoretically, A_(max) should be the point that dA/dT reaches 0. The rate of change (dA/dT) should then become negative to indicate that amplitude is dropping after Amax. Because of the empirical equation chosen, dA/dT=aA²/(e^(bA)−1), dA/dT will never achieve a negative value unless one of the coefficients is negative. However, in order to fit the model shown, coefficients a and b should both be positive values. A potential issue arises with the use of positive coefficients. Since Amax is the maximum amplitude, all amplitude measurements thereafter should be less than Amax. In other words, the derivative after Amax should be negative. However, as a result of the simplistic equation used to model Amax behavior, certain embodiments of the model may not achieve a negative value for dA/dT. This particular graph of dA/dT v. Amplitude shown in FIG. 7B will only approach dA/dT=0 as Amplitude approaches infinity. However, as we know, Amplitude never actually reaches infinity. Therefore, there may be some specific cutoff threshold value. This value may be set by a computer, for example. For example, setting the requirement that Amax occurs when the change of Amplitude over time eventually slows down to some value, e.g. when dA/dT=0.1.

The coefficients a and b are responsible for determining where the graph of dA/dT will peak, and how quickly it will return to 0 after it peaks. In general terms, coefficient a is responsible for raising the peak of the graph, while coefficient b is responsible for determining how quickly the peak will descend towards 0. Both coefficients are relevant because they influence when dA/dT will reach the cutoff threshold for determining the calculated A_(max) value. A larger a value will result in a correspondingly larger peak value. A larger b value will result in a graph that descends more rapidly. For example, when coefficient a doubles to 0.022, there is a correlated elevation in the peak value, and the calculated A_(max) value, as shown in FIG. 7C.

If a calculated Amax threshold occurs when dA/dT=0.1, the graph shown in FIG. 7C does not extend far enough along the amplitude axis to show what calculated Amax would be i.e. Amax would be greater than 60. The patient having coefficient a value of 0.022 has a quantitatively greater clotting strength than the patient having coefficient a value of 0.011.

When coefficient b doubles to 0.208, the graph approaches 0 more quickly as shown in FIG. 7D.

In this case, if calculated Amax were to occur at a threshold when dA/dT=0.1, Amax would occur well before Amplitude=60. In other words, the patient with coefficient b value of 0.208 has significantly weaker clotting than the patient with coefficient b value of 0.104. Noticeably, this increase in coefficient b has dropped the value of Acrit as well. As can be understood, the coefficients do not operate on isolated segments of the graph, but rather work together to produce the entire waveform, including the values for Amax and Acrit. However, as a general concept, a larger a coefficient makes the plot peak larger, and a larger b coefficient brings the plot peak down and causes a more rapid descent towards dA/dT=0. Each a and b coefficient may vary from patient to patient. The a and b coefficients of each patient allow us to create a custom model for each patient based on the Acrit data acquired. For example, as shown in FIG. 7E, data points may be obtained as shown by the squares up until point Acrit.

A program, such as MatLab (commercially available from The MathWorks Inc., Natick, Mass.), may be used to fit the dA/dT data points to the empirically derived equation for dA/dT using the least squares method. Again, the dA/dT data points may be obtained by using the Amplitude data acquired from the TEG procedure. A computer may automatically calculate the dA/dT values.

Amplitude data=[A ₀ ,A ₁ ,A ₂ ,A ₃ ,A ₄ , . . . A _(CRIT−1) ,A _(CRIT) ,A _(CRIT+1)]

The rate of change of A₁ for example is (A₁-A₀) divided by τ, the time between data acquisition measurements.

$\frac{dA}{dT} = \left\lbrack {\frac{A_{1} - 0}{\tau},\frac{A_{2} - A_{1}}{\tau},\frac{A_{3} - A_{2}}{\tau},{\ldots \mspace{14mu} \frac{A_{CRIT} - A_{{CRIT} - 1}}{\tau}},\frac{A_{{CRIT} + 1} - A_{CRIT}}{\tau}} \right\rbrack$

The values for dA/dT, that may be obtained using the above equation, are plotted against the Amplitude values up to Acrit. This produces the first part of the waveform up to the peak of the plot. The empirical equation:

$\frac{dA}{dT} = \frac{a \cdot A^{2}}{e^{bA} - 1}$

is then fit to the data points up to Acrit using the least squares method. By fitting the data to the empirical equation, coefficients a and b are determined. This may be done by a computer. Fitting the data to the equation gives coefficients a and b values that produce the best fit to the dA/dT equation using the least squares method. Once the a and b coefficients are obtained from the collected data points up to Acrit, the equation may be extended to Amax. A graph may be used to find the calculated Amax by simply plugging in the best fit a and b coefficients into the dA/dT equation and seeing when the Amax threshold level is reached. As discussed above, the derivative, dA/dT value will approach 0 as Amplitude goes to infinity. This is a property of the model equation chosen. As a result, a trigger threshold dA/dT value may be used to determine when Amax occurs. This trigger threshold can be determined based on empirical data, or when the derivative has reached an adequately low level, for example when dA/dT drops to less than 0.1 mm/time unit.

Example II

The dAmax and Acrit values were obtained from four classes of patients, namely healthy volunteers, trauma patients with no significant bleeding (i.e., hemorrhage), trauma patients with significant hemorrhage needing 6-10 units of blood in 6 hours, and trauma patients with massive hemorrhage needing 10 units of blood in 6 hours or dying of exsanguination in 6 hours.

Blood was collected and analyzed according to standard methods. By way of example, from healthy volunteers, citrated whole blood samples were obtained from healthy volunteers accordingly to standard methods. Similar techniques are performed on blood samples from trauma patients.

Briefly, venipuncture is performed with a 21-gauge needle in an antecubital vein, and blood is collected into evacuated containers containing 3.2% citrate (e.g., a 3.5 mL plastic Vacutainers® containing 3.2% citrate). By a “healthy individual” or “healthy volunteer” is meant a healthy individual who is of reproductive age. For example, if the patient is a human, a healthy volunteer is man or woman between the ages of about 14 years old to about 44 years old, or between about 18 years old to about 40 years old. For each sample of blood, 340 uL of the citrated whole blood (i.e., from the Vacutainers that contained 3.2% citrate) are added to a cup containing 20 μL 0.2 mol/L of CaCl₂ and the assay performed on a TEG 5000 Thrombelastograph system (commercially available from Haemonetics, Inc., Braintree, Mass.). Note that if a multi-channel cassette is used, the channel for the particular sample is pre-loaded with 20 μL 0.2 mol/L of CaCl₂, to which 340 uL of the citrated whole blood is added.

Table 2 provides the raw data (CRD) from healthy volunteers. Note that in the tables, “CFF” stands for citrate functional fibrinogen TEG, where the extrinsic pathway is activated by the addition of tissue factor and calcium, while the platelet aggregation is inhibited (due to the presence of a monoclonal glycoprotein GPIIb/IIIa receptor antagonist in the Functional Fibrinogen reagent, commercially available from Haemonetics Inc., Braintree, Mass.). Therefore, the CFF number represents the amount of fibrinogen contribution to the strength of the clot. “CFT” is the citrated rapid TEG, which adds kaolin to activate the intrinsic pathway. Thus, the CFT number represents the clot strength as contributed by both platelets and fibrinogen. “CN” is simply native blood or native blood that has been citrated but has no kaolin or tissue factor added. Table 3 provides the healthy volunteer data sorted by CN MA. Table 4 provides the raw data (CRD) from trauma patients sorted by significance of hemorrhage. Table 5 provides the trauma patient data sorted by significance of hemorrhage, where the errors are eliminated. The data from these patients were taken from the TEG apparatus (commercially available from Haemonetics, Corp., Braintree, Mass.) using the computer software provided with the apparatus and additional software for speedy calculations. Note that the data was taken from native TEG (i.e., citrated or non-citrated whole blood without the addition of clotting factors or enhancers of clot formation such as kaolin). These data were then used to calculate Acrit and dAmax values using the equations described above.

In FIGS. 8 and 9, dAmax values were then plotted as a function of Acrit. The data plotted are healthy volunteers (triangles), patients with no massive hemorrhage (squares), patients with significant hemorrhage (circles), and patients with massive hemorrhage (diamonds). A patient with no massive hemorrhage (or no significant hemorrhage) is a patient who does not need more than 6 units of blood in 6 hours. A patient with significant hemorrhage needs between 6 units and 10 units of blood in 6 hours. And a patient with massive hemorrhage is a patient who either needs more than 10 units of blood in 6 hours or less, or who dies of blood loss in 6 hours.

As shown in FIG. 8, patients with massive hemorrhage (orange diamonds) had slightly lower dAmax and slightly lower Acrit values than patients with no significant hemorrhage (blue squares). The difference between both of these populations is striking when compared to healthy volunteers (green triangles) who had higher Acrit values and lower dAmax values. FIG. 9 shows that patients with significant hemorrhage (yellow circles) overlap the patients with massive hemorrhage, but had very little overlap with patients with no significant hemorrhage.

The data is FIGS. 8 and 9 show that healthy volunteers form a tight cluster of fairly high Acrit, and modest dAmax. Furthermore, patients who are injured but do not have significant hemorrhage (i.e., do not require transfusion of more than 6 units of blood in 6 hours) will increase dAmax dramatically (i.e., by increasing generation of thrombin). By doing so, this increase in dAmax in injured patients will shift Acrit values lower. This may be due to the thermodynamic efficiency of clot formation being lower at higher velocity (a common feature of enzymatic chemistry) or simply that there are consumptive processes at work. However, massive bleeders will fail to up-regulate their dAmax and also have a subnormal (i.e., low) Acrit, either from catalysis failure or exhaustion of resources.

Example III

To even more accurately predict the MA, the discontinuity with the model near MA was addressed by taking the area under the tracing and relating it to MA (i.e., Amax). Since there is no closed form solution to relate the MA in the time domain back to the integrated differential equation in the amplitude domain, the relationship will be modeled. By dimensional analysis the solution to the integral of dA/dT with respect to A from A=0 to A=∞ should have units equivalent to A². Calling this area product “Q”, this provided a solution that must be in the form Q=c(Amax²)+d where c is a function zero order in Amax and T (note that Amax is used synonymously with the time-dependent variable “MA”). The simplest model for this is thus merely a linear fit to existing healthy volunteer and patient data.

The results described here provide the identification of new parameters that can be obtained very early, and that ae reflective of the maximum amplitude. The maximum amplitude is one of the most important predictors of outcomes for trauma patients, and whether or not such patient will require a blood transfusion. In healthy volunteers, the MA occurs typically between about 15 to about 35 minutes after the start of the viscoelastic assay. A lower MA may reflect a hypocoagulable state, such as platelet dysfunction or thrombocytopenia, and thus identifies a patient that is likely to require a blood transfusion. Since the Acrit is reflective of MA, an Acrit that is lower than an equivalent MA at about 15 to about 35 minutes identifies the patient as likely to require a blood transfusion.

As discussed in more detailed in Example IV below, FIG. 15 shows the data points of MA plotted against the area under the curve (see red shaded area in FIG. 10) fit to the model. The area under the curve is clearly shown in FIG. 10 (red shaded area). This red shaded area stops in FIG. 10 at “crit” (i.e., Acrit), which occurs when dA is at its maximum value.

FIGS. 11 and 12 are two graphs showing the correlation between plotting the % sensitivity versus % specificity for the rate of change of the time-independent TEG area under the curve (TITAUC). The straight diagonal line shows a 50/50 chance of prediction of a patient with significant hemorrhage (FIG. 11) or massive hemorrhage (FIG. 12). Plotting the area under the curve (see FIG. 10), FIG. 11 shows that using the Acrit and dAmax values, a patient with significant hemorrhage could be predicted with an accuracy of 83.65% and FIG. 12 shows that using the Acrit and dAmax values, a patient with massive hemorrhage could be predicted with an accuracy of 88.23%.

Example IV

The MA of a TEG curve is the hypothetical representation of the maximum clot strength which represents a combination of platelet and fibrinogen contributions to the clot's architecture and ultrastructure. However, this MA number is not a simple additive sum, as platelets and fibrinogen are not merely a homogeneous admixture (see FIGS. 5A and 5B). Instead, platelets form nodes in the fibrin network which catalyze the formation of and organize the network as well as actively generating internal stresses by their contraction which enhance the shear and tensile strength of the clot. The complex, non-additive relationship of platelets and fibrinogen to clot strength is exemplified by the fact that an entirely platelet-free clot loses around 80% of its strength, but a fibrinogen free clot loses 100% of its strength.

Thus, simple differential thromboelastography analysis between samples with and without platelet inhibitors is not a fully accurate measure of the individual contributions of platelets and fibrinogen, or more importantly which of these elements is deficient in the setting of a given individual, such as a trauma patient who may or may need a blood transfusion.

To obtain a faster parameter reflective of MA, the TEG tracings of the 161 healthy volunteers were analyzed and more information was extracted from these TEG tracings (also referred to as TEG curves) to obtain novel parameters. These tracing are drawn initially in the time domain (see. e.g., FIG. 4A or 5A), but can be transformed into other coordinate systems that reveal other information encoded in the tracing. For example, the reference frame of the TEG tracings can be arbitrarily shifted to a set of axes which appear to encode the greatest information content.

Another method is to deliberately transform the data into a new set of coordinates may be based on inherent physical properties of the system, for example transforming a complex signal read out in the time domain into the frequency domain to reveal hidden patterns (e.g., a fourier transform).

Similarly, one can transform a signal in the time domain to a signal in the amplitude domain.

FIG. 6A, for example, classic TEG tracing of one typical healthy volunteer. In FIG. 4A, time (in min) is on the X axis and amplitude (in mm) is on the Y axis).

A term of interest, such as the amplitude, can be pulled out of the non-periodic signal (e.g., a TEG tracing) and recast as an independent variable that term (i.e., the amplitude) as the domain, with the rate of change of amplitude as the new dependent variable, dA. This is shown in FIG. 6B. FIG. 6B thus effectively removes the time variable.

Thus, just as MA is an obvious feature of the time-domain TEG curve, a global maximum exists in the time independent TEG curve. This is called the dAmax for the maximum in the rate of change of A, the corresponding amplitude is called the critical amplitude or Acrit. Acrit is shown on FIG. 6A and FIG. 6C. In FIG. 6C, it is clear that Acrit occurs at dAmax (i.e., at the time that dA is at its maximum value. In the healthy volunteer shown in FIG. 6A, Acrit occurs when the dA is 0.68 and the A is 11.64 mm (see FIGS. 6A and 6C). The Amax is 55.62 mm, and occurs at approximately 38 minutes (see FIG. 6A).

The TEG tracing of another healthy volunteer is shown in FIG. 7A. In FIG. 7A, it is evident that the Acrit parameter is obtainable before 5 minutes after the beginning of clotting (i.e., before the A5 time). In the patient shown in FIG. 7A, the A5 parameter (i.e., 5 minutes after clotting) is obtained 18.17 minutes after the start of the TEG assay. However, the Acrit parameter is obtained at approximately 17 minutes after the start of the assay.

Thus, in some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 5 minutes after the blood starts clotting in a viscoelastic assay. In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 10 minutes after the blood starts clotting in a viscoelastic assay. In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 15 minutes after the blood starts clotting in a viscoelastic assay.

In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 18 minutes after the start of the viscoelastic assay (i.e., after the blood sample from the patient is placed into the viscoelastic analyzer for analysis). In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 20 minutes after the start of the viscoelastic assay. In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 25 minutes after the start of the viscoelastic assay. In some embodiments, the invention provides a parameter for detecting whether or not a patient will need a blood transfusion less than 30 minutes after the start of the viscoelastic assay.

FIG. 13 shows that the mapping of Acrit and Amax parameters of the tracing of FIG. 7A in a Planck-like fit is stable. (See red line in FIG. 14A, fit up to the maximum at Acrit).

The behavior in the TEG tracings suggests some degree of coupling with some hidden variables. Pulling these hidden variables out requires integrating this differential equation:

dA/dT=f(A)

This equation is an implied function and is clearly a nonlinear differential equation even in the case of the simplest model. So solving in closed form is likely not possible and there is a good chance that its expansion will not converge.

Note that initially the TEG tracings from the healthy volunteers were modeled with the empirically derived equation

dA/dT=aA ²/(e ^(bA)−1)

Fitting to this model equation was used to test the robustness of the fit. The same fitting was done, varying only a and b, to only the accelerative phase of the curve, prior to the maximum value of dA (dAmax).

As a first step to deriving this model, a curve fitting was attempted as a methodology for prediction of early from late (notably attempts to do this in the time domain have been notoriously unsuccessful). The goal was to develop the simplest possible model for interpolation and extrapolation in order to avoid the pitfalls of overfitting. Furthermore, the model developed is based on other natural phenomena not simply a polynomial. Thus, a lower order modification of Planck's equation on this basis, as it contains only 2 fitting parameters in its simplest form. These are shown in FIG. 13, and the fit on the two parameters (Acrit and Amax) is stable.

However, as shown in FIG. 14, the fit converges with increasing data. This convergence is an important characteristic of predictive stability. On the x axis in FIG. 14 is the time off-set from Acrit in minutes. As time increases, there is an increasing progression of inclusion of data points in the TEG tracing. 0 on the x-axis in FIG. 14 is Acrit. On the y-axis in FIG. 14 is the normalized difference in area under the curve between the model and the actual Amplitude domain data. Note that this is simply a convenient representation of the aggregate error of the fit. The root mean square deviation (or root mean square error) (RMSE) for each point can also be used to obtain an equivalent result.

As FIG. 14 shows, the more the TEG curve is allowed to progress before attempting the fit, the better the prediction, but this rapidly converges near Acrit. This increasing fit and the rapid convergence near Acrit provides that the model is sound.

Thus, in many individuals' TEG tracings, the accelerative phase fit was nearly superimposable with the full tracing fit all the way to MA. Interestingly, even when the least squares fit is poor, the two model trajectories appear to converge at MA (see FIG. 13). This is suggestive that there is a valid physical basis to the trajectory equation. However, the behavior of the time-independent TEG tracing (TITT) and the model diverge near MA (see FIG. 13). This is because the actual TITT is not smooth in this limit, and is no longer a explicitly definable function as it doubles back on itself as the curve decays based on physical processes distinct from its formation, whereas the model is asymptotic at the X-axis (i.e. in the model the clot grows forever albeit at rate limit 0 at infinity).

To map this back to the MA, since the model is asymptomatic at the x-axis, no explicit coordinate pair defines MA. Therefore, this is analogous to infinite, infinitely slow growth of the clot. The model

dA/dT=aA ²/(e ^(bA)−1)

is solved, yielding A(t). Theoretically A(t) could then be evaluated at infinity to yield the MA, but of course this is not possible.

Instead the area under the model curve at infinity is evaluated which should have units of mm-squared per second which obviously yields infinite amplitude when evaluated at T=infinity. This can be done by taking the area under the tracing and relating it to MA. Since there is no closed form solution to relate the MA in the time domain back to the integrated differential equation in the amplitude domain, the relationship will be modeled. By dimensional analysis, the solution to the integral of dA/dT with respect to A from A=0 to A=∞ should have units equivalent to A². Calling this area product “Q”, this provided a solution that must be in the form Q=c(A_(max) ²)+d where c is a function zero order in Amax and T (note that Amax is used synonymously with the time-dependent variable “MA”). The simplest model for this is thus merely a linear fit to existing healthy volunteer and patient data.

In fact, the area under the curve converges itself and should have an explicit relation (albeit unknown) to the solution to the differential equation which must include this integral. Thus, evaluated the explicit integral, a and b are unitless constants and yield a result in terms of Amplitude squared.

$\int_{0}^{\infty}{\frac{{aA}^{2}}{e^{bA} - 1}\ {dA}}$

Therefore, a function of this area was hypothesized to yield MA. This was then tested against the actual data.

As shown in FIG. 15, this relationship is stable even when the fit is run only to Acrit and yields the very simple prediction:

MA is approximately equal to 15(ln Q)+12 mm

The test for fit was on a subset of the actual human data where the original curve fit was good (see FIG. 15). Note that the “goodness” of the curve fit was not being tested. Rather, the test was whether the hypothesis that MA bears an explicit mathematical relation to the integral in question was plausible. Our test revealed that the MA clearly bears an explicit mathematical relation to the integral. This appears to conform to a logarithmic fit but it is actually more likely a fractional power.

Thus, these studies show that Acrit occurs very early—even before the A5 min or A10 min marks which some practitioners advocate as a means of early estimation of MA (see FIG. 7A). Note that FIG. 7A (and FIG. 6A) is a native tracing which accounts for the long R-time.

With these new parameters (e.g., Acrit, and dA), numerous objectives can be achieved in the quest to predict late TEG events in a very rapid fashion.

Example V

Massive hemorrhage is a significant cause of death in trauma patients.

However, all the information needed to determine if a patient (e.g., a trauma patient) will require a large blood transfusion within six hours (or die) is contained within a blood sample taken from that patient. Currently, some of the best indicators of significant or massive hemorrhage in the patient take over 40 minutes to obtain (i.e., the MA value). The methods described herein, and the new parameters (e.g., dAmax and Acrit) allow accurate prediction of the MA in a much fast time (e.g., less than twenty, or less than fifteen, or less than ten, or less than five minutes after the start of the viscolastic assay).

In addition, the methods and parameters described herein are useful for determining what part of the coagulation process is not functioning normally in a patient who might experience significant or massive hemorrhage. As discussed above, hemostasis is a complicated, tightly regulated process involving multiple factors (see FIG. 1). The intrinsic pathway to coagulation is initiated by providing a surface on which the clotting factors can aggregate. To do this using a viscoelastic assay, reagents such as kaolin are added to provide that surface. This surface contact can activate Factor XII to form Factor XIIa which then activates Factor XI to form Factor XIa. In other words, the surface of kaolin is acting like Kininogen and kallikrein in FIG. 1. The extrinsic pathway is the tissue factor pathway, and provides a thrombin burst during traumatic injury. As shown in FIG. 1, trauma acts via Factor VIIa and tissue factor to activate Factor X to form Factor Xa.

Platelets also play a role in clot formation. During injury, platelets immediately form a plug at the injury site. The clotting cascade pictured in FIG. 1 occurs simultaneously, and contributes fibrin to strengthen the clot. Thus, platelets and fibrin (and its precursor, fibrinogen) contribute to clot strength; however, their contributions are not additive (see FIGS. 3A and 3B). It would be useful, however, to determine if problems with clotting are due to the fibrin contribution or the platelet contribution, because identifying the source of the problem could lead to better patient treatments. For example, if the lack of clotting was the result of low platelet activation, the patient could be treated with a platelet activator such as Factor VIIa, desmopressin, and thrombopoietin and thrombopoietin mimetics. Conversely, if the lack of clotting was the result of low fibrinogen activation to produce fibrin, the patient could be treated with thrombin and/or fibrinogen to increase fibrin production.

Surprisingly, the methodologies described herein are able to detect contributions of fibrinogen to clot strength, and are able to detect contributions of platelets to clot strength. In FIG. 16, increasing amounts of fibrinogen are added to a blood sample ranging from the hypo to hypercoagulable range while platelet count is held constant. These spiked samples were subjected to viscoelastic analysis, and the dAmax values plotted against the amount of added fibrinogen. As shown in FIG. 16, fibrinogen activity demonstrated a very tightly correlated sigmoid relationship to dAmax. In other words, in an artificial system (i.e., using spiked blood), dAmax was found to be correlative to functional fibrinogen level, and therefore is a marker of the contribution of fibrinogen (and fibrin) to a blood clot.

Similarly, in order to derive correlates of time-independent TEG parameters to total platelet function, another artificial system was set up in which platelets were depleted from whole blood by differential centrifugation, and then counted. The blood samples containing various amounts of platelets were then subjected to viscoelastic analysis and the dAmax value multiplied by the Acrit value to arrive at a “critical product”. This “critical product” value was plotted against the number of platelets in the sample in FIG. 17, and the resulting graph shows a clear linear relationship between the product of dAmax and Acrit (the “critical product”) and total platelet count.

Thus, using the methods and parameters identified herein allows the dissection of the blood clotting into the contributions of fibrinogen and platelets.

Finally, as shown in FIG. 18, the area under the receiver operating characteristic curve (ROC) of the time-independent TEG (TITAUC) for patients with massive hemorrhage is more accurate at predicting patients who will suffer massive hemorrhage compared to the AUC for maximum amplitude (MA; red line), the AUC for the alpha angle (purple line), the AUC for activated clotting time (ACT; brown line) and the AUC for the International Normalization Ratio (INR) (green line).

The embodiments of the invention described above are intended to be merely exemplary; numerous variations and modifications will be apparent to those skilled in the art. All such variations and modifications are intended to be within the scope of the present invention as defined in any appended claims.

TABLE 2 CRT CN CFF CRT Amax CN Amax CFF Amax CRT Acrit CN Arit CFF Acrit dAmax dAmax dAmax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) (mm) (mm) (mm) 20064 62.4453125 57.59375 22.6015625 1.9296875 16.82421875 3.60546875 1.453125 0.8203125 0.5390625 20066 57.40625 52.2265625 17.3515625 1.25 17.84375 2.29296875 0.984375 0.46875 0.3515625 20067 59.2578125 59.9609375 21.8046875 16.15625 12.78125 2.609375 0.984375 0.890625 0.375 20068 63.359375 55.671875 24.453125 1.37890625 14.97265625 4.49609375 1.0546875 0.5859375 0.6328125 20069 68.65625 64.484375 25.484375 2.85546875 15.828125 5.5390625 2.0390625 0.9375 0.84375 20070 61.7890625 56.046875 18.03125 14.01171875 17.6328125 3.58203125 1.1953125 0.5625 0.3984375 20072B 58.0390625 47.9375 16.1328125 1.71875 14.1875 3.37109375 1.125 0.328125 0.3046875 20073D 68.234375 62.515625 21.6640625 20.4453125 18.2421875 4.33203125 1.3125 0.609375 0.5390625 20074B 63.9921875 59.0234375 22.484375 5.33984375 13.6484375 3.8046875 1.1953125 0.65625 0.65625 20075D 69.59375 62.8203125 24.3828125 16.63671875 16.578125 5.421875 1.4765625 0.703125 0.5625 20076B 59.9140625 51.78125 17.2109375 5.45703125 16.2734375 2.24609375 1.0546875 0.375 0.3515625 20077D 61.34375 57.7578125 16.2265625 15.8515625 14.0234375 2.52734375 1.03125 0.515625 0.3515625 20078B 56.1640625 50.5859375 18.265625 1.21484375 15.83984375 3.62890625 1.1015625 0.4921875 0.3046875 20079D 61.015625 48.078125 18.3359375 6.2421875 17.10546875 3.37109375 1.265625 0.3984375 0.3984375 20080B 64.2265625 61.5078125 25.4140625 18.60546875 18.640625 4.63671875 1.2421875 0.65625 0.4921875 20081D 69.5234375 63.0546875 25.8125 3.23046875 19.96484375 5.59765625 1.6171875 0.4921875 0.6328125 20082B 55.53125 54.6171875 18.3125 0.93359375 14.5859375 3.06640625 0.9140625 0.515625 0.3515625 20083B 67.4375 56.3046875 22.4140625 17.10546875 21.06640625 4.6953125 1.2890625 0.3984375 0.609375 20084D 62.1875 57.6640625 19.578125 14.3984375 19.84765625 3.21875 1.078125 0.4453125 0.328125 20085D 62.5390625 52.625 19.8359375 1.73046875 14.45703125 4.109375 1.3828125 0.4921875 0.28125 20086B 62.2578125 54.125 22.7890625 1.859375 14.87890625 4.70703125 1.171875 0.4921875 0.5390625 20087D 69.4765625 64.953125 23.984375 18.1015625 18.7578125 5.8671875 1.40625 0.796875 0.46875 20088B 61.625 54.8984375 17.609375 19.33203125 19.8359375 2.99609375 0.9140625 0.421875 0.3046875 20090B 60.40625 50.421875 20.7265625 6.03125 18.5703125 4.16796875 1.078125 0.46875 0.4921875 20091D 66.453125 62.9140625 23.46875 2.01171875 18.4765625 4.30859375 1.4765625 0.65625 0.4453125 20092B 69.3125 60.546875 21.6875 14.6328125 18.81640625 4.33203125 1.640625 0.6328125 0.3515625 20093D 71.5625 63.8515625 25.3671875 19.625 17.1875 5.75 2.484375 0.5625 0.65625 20094B 65.28125 61.2265625 20.984375 2.57421875 16.94140625 2.8203125 1.4765625 0.7265625 0.46875 20095D 67.7421875 62.46875 23.890625 17.45703125 17.703125 4.00390625 1.2890625 0.46875 0.3984375 20096B 64.53125 54.6875 19.2734375 5.59765625 13.7421875 3.6875 1.1953125 0.421875 0.1875 20097D 66.640625 69.359375 20.375 14.10546875 16.49609375 3.44140625 1.2421875 1.0078125 0.3984375 20098B 61.953125 57.59375 17.9609375 1.66015625 20.1875 3.39453125 1.1015625 0.515625 0.3984375 20099D 58.578125 59.328125 18.3828125 13.42578125 12.6875 3.546875 0.8203125 0.5625 0.1875 20100B 52.90625 45.2421875 20.8671875 1.49609375 15.91015625 3.1015625 1.3359375 0.5390625 2.203125 20101D 60.3828125 53.09375 18.875 1.4140625 16.44921875 3.76953125 1.359375 0.4921875 0.4453125 20102B 68.9140625 61.0625 25.9765625 6.5 19.8828125 5.99609375 1.5 0.5625 0.6796875 20103D 72.5703125 67.9765625 28.109375 10.2734375 24.265625 6.359375 1.921875 0.796875 0.75 20104B 65.3515625 64.6953125 27.4296875 17.41015625 24.21875 7.68359375 1.0546875 0.703125 0.4921875 20105D 60.734375 55.71875 19.1796875 1.26171875 22.0625 4.1796875 1.3359375 0.375 0.234375 20106B 62.046875 52.4375 23.5859375 1.89453125 14.57421875 5.375 1.7578125 0.6328125 0.375 20108B 54.5234375 46.6484375 16.296875 15.9453125 15.53515625 2.73828125 0.84375 0.4453125 0.2578125 20109D 62.1640625 58.71875 20.3046875 1.70703125 18.78125 4.68359375 1.5234375 0.609375 0.5390625 20110B 56.28125 47.6328125 16.953125 1.09765625 16.859375 2.796875 1.0078125 0.421875 0.328125 20111D 61.53125 55.2265625 18.59375 1.37890625 16.484375 5.3046875 1.2890625 0.515625 0.46875 20112B 62.8203125 57.640625 21.453125 1.71875 21.0078125 4.49609375 1.453125 0.421875 0.4921875 20113D 65.046875 61.6953125 24.3125 16.2734375 18.53515625 3.7578125 1.5 0.6328125 0.515625 20114B 57.8984375 52.34375 20.046875 11.75 17.17578125 3.546875 0.890625 0.4453125 0.46875 20115B 61.8359375 52.90625 18.359375 1.5546875 22.4375 3.40625 1.265625 0.421875 0.375 20116D 58.4375 56.796875 19.6953125 1.70703125 17.08203125 2.9375 1.4765625 0.4453125 0.421875 20117B 56.28125 51.4296875 17.890625 12.125 18.55859375 2.92578125 0.984375 0.3984375 0.3984375 20118D 67.578125 63.8515625 22.34375 3.55859375 16.7890625 3.58203125 1.8984375 0.796875 0.6328125 20119B 67.0390625 63.7109375 22.203125 13.87109375 17.66796875 4.0390625 1.2890625 0.6328125 0.421875 20120D 67.1796875 59.7734375 22.7890625 14.48046875 17.64453125 5.19921875 1.4296875 0.5859375 0.6328125 20121B 58.0859375 59.9375 18.6171875 13.30859375 14.3984375 3.08984375 1.1015625 0.890625 0.5390625 20122D 69.5234375 62.84375 26.140625 11.1171875 15.8984375 4.61328125 2.109375 0.5625 0.6796875 20123B 55.765625 56.5859375 21.7578125 1.578125 17.22265625 5.01171875 1.359375 0.4921875 0.6796875 20124D 61.203125 53.234375 20.890625 2.08203125 18.3828125 9.59375 1.4765625 0.609375 0.375 20125B 61.296875 54.8046875 20 16.75390625 17.90234375 4.33203125 1.1015625 0.4921875 0.3984375 20126D 61.8359375 52.34375 20.75 1.63671875 13.4375 0.6640625 1.4765625 0.703125 0.46875 20127B 57.5703125 52.4140625 19.3671875 1.3203125 13.578125 3.7578125 1.171875 0.609375 0.46875 20128D 64.1796875 65.0234375 24.6875 5.52734375 15.3125 11.26953125 1.5234375 0.75 0.6796875 20129B 60.3359375 52.625 19.203125 10.5078125 14.703125 3.91015625 1.5 0.46875 0.4453125 20130D 69.171875 66.3828125 22.5546875 1.58984375 23.12890625 4.8828125 1.4296875 0.5859375 0.609375 20131B 59.28125 42.2421875 18.5234375 5.48046875 14.4453125 4.07421875 1.3359375 0.328125 0.3984375 20132D 68.4921875 59.1640625 25.859375 6.01953125 21.60546875 4.77734375 1.4765625 0.5390625 0.5859375 20133B 61.765625 59.703125 17.3984375 1.90625 17.6796875 3.34765625 1.03125 0.515625 0.3984375 20134D 62.4921875 61.2734375 21.1953125 1.25 15.44140625 0.79296875 1.265625 0.7734375 0.4921875 20135B 59.4453125 50.84375 20.7265625 14.984375 16.16796875 3.359375 1.21875 0.5390625 0.5625 20136D 67.25 61.90625 23.375 2.26953125 18.5234375 5.10546875 1.9453125 0.515625 0.5390625 20137B 55.2734375 43.0625 15.21875 0.83984375 18.55859375 2.75 0.8203125 0.3046875 0.328125 20138D 56.703125 49.8828125 17.234375 1.33203125 23.1171875 2.8203125 1.1015625 0.28125 0.609375 20139B 64.53125 58.2734375 22.4140625 2.76171875 20.3046875 5.140625 1.7578125 0.609375 0.609375 20140D 67.71875 61.8828125 26.46875 2.3984375 18.8515625 5.5390625 1.640625 0.84375 0.703125 20141B 60.78125 55.0390625 20.0234375 2.50390625 19.25 4.30859375 1.2421875 0.46875 0.4453125 20142D 65.09375 58.5546875 26.328125 6.6875 28.87109375 5.8203125 1.78125 0.4921875 0.75 20144B 55.1796875 50.515625 18.875 1.47265625 16.33203125 2.69140625 0.7734375 0.3984375 0.3046875 20145D 61.625 53.28125 21.7109375 5.85546875 16.5546875 2.71484375 0.8671875 0.46875 0.3515625 20146B 62.7265625 48.8515625 21.2421875 1.484375 17.66796875 4.42578125 1.359375 0.3515625 0.4921875 20147D 63.171875 52.3203125 22.8828125 1.75390625 17.71484375 3.96875 1.5234375 0.3515625 0.46875 20148B 60.1953125 50.3984375 34.1328125 2.10546875 18.30078125 45.8515625 1.1015625 0.4453125 91.453125 20149D 63.125 48.2890625 19.625 1.56640625 14.046875 3.58203125 1.4296875 0.328125 0.3046875 20150B 57.265625 41.796875 17.46875 1.61328125 15.2890625 0.40625 1.1484375 0.234375 0.375 20151D 56.28125 49.34375 20.2109375 1.14453125 16.671875 3.83984375 1.1484375 0.328125 0.3515625 20152B 57.03125 45.21875 20.234375 1.80078125 20.76171875 4.2734375 1.1484375 0.3984375 0.5625 20153D 62.2578125 47.6328125 23.0703125 1.625 19.61328125 3.2890625 1.03125 0.3046875 0.421875 20154B 64.90625 55.1328125 22.671875 24.875 22.0625 3.6875 1.40625 0.421875 0.5625 20155D 64.4140625 52.671875 18.734375 1.9296875 19.90625 5.7265625 1.5 0.375 0.515625 20156A 59.234375 49.109375 21.171875 1.4140625 18.078125 4.82421875 1.3125 0.421875 0.7734375 20157D 60.7578125 54.875 22.0390625 2.421875 13.19140625 3.21875 1.78125 0.4921875 0.46875 20158B 61.1328125 52.3203125 19.90625 15.8984375 18.98046875 3.51171875 0.9375 0.3984375 0.5859375 20159D 62 54.453125 21.6171875 1.89453125 20.31640625 4.484375 1.3359375 0.4453125 0.515625 20160B 62.0703125 55.671875 23.703125 1.90625 17.99609375 4.8828125 1.171875 0.4921875 0.5625 20161D 55.953125 53.8203125 17.65625 1.4609375 18.640625 1.98828125 1.03125 0.375 0.3046875 Donor 20003 63.359375 54.0078125 22.3203125 2.76171875 32.38671875 4.4609375 1.4765625 0.4453125 0.796875 Donor 20004 70.3203125 64.390625 27.78125 7.14453125 24.78125 4.51953125 1.7109375 0.796875 3.8671875 Donor 20005 61.1796875 53.3515625 19.8828125 1.54296875 16.56640625 4.09765625 1.1484375 0.3515625 0.4921875 Donor 20006 66.921875 57.2890625 24.875 7.3671875 18.9921875 4.4609375 1.265625 0.65625 0.703125 Donor 20007 68.2109375 56.9140625 29.9609375 8.22265625 22.9765625 12.875 1.8984375 0.515625 1.3125 Donor 20008 60.921875 52.765625 19.53125 11.71484375 19.1328125 3.86328125 1.0546875 0.328125 0.3984375 Donor 20009 63.7578125 51.3828125 21.21875 2.05859375 19.82421875 3.6640625 1.7109375 0.3984375 0.46875 Donor 2001 63.96875 50.0703125 17.703125 17.83203125 22.05078125 3.04296875 1.7109375 0.4453125 0.2578125 Donor 20010 59.1171875 52.8359375 15.21875 22.6015625 17.046875 3.16315625 1.21875 0.375 0.4453125 Donor 20011 63.734375 55.7421875 21.4765625 3.8515625 16.00390625 4.8125 2.625 0.6796875 0.421875 Donor 20012 56.890625 57.7578125 22.25 3.0078125 17.3984375 4.5078125 1.875 0.515625 0.328125 Donor 20013 74.6328125 67.9765625 26.6328125 2.515625 18.4765625 6.41796875 2.484375 0.984375 0.6796875 Donor 20014 71.46875 63.2890625 26.0234375 1.90625 18.171875 5.703125 1.734375 0.515625 0.5625 Donor 20015 75.1015625 67.015625 32.1171875 5.33984375 23.48046875 7.96484375 2.8828125 0.9140625 1.0546875 Donor 20016 70.34375 59.0234375 25.390625 3.6640625 18.88671875 6.08984375 2.484375 0.9609375 0.7734375 Donor 20017 53.703125 49.5546875 19.71875 1.1796875 13.37890625 3.5703125 1.03125 0.3984375 0.5625 Donor 20018 61.53125 59.421875 20.8671875 2.515625 18.76953125 6.7139375 1.40625 0.4453125 0.421875 Donor 20019 63.7578125 51.921875 22.8828125 18.79296875 17.9375 2.69140625 1.1015625 0.328125 0.4453125 Donor 2002 56.796875 61.90625 20.7734375 1.73046875 13.91796875 4.25 1.4765625 0.9143625 0.609375 Donor 20020 68.046875 62.84375 26.046875 1.9765625 13.4375 2.234375 1.875 0.65625 0.796875 Donor 20021 58.8359375 56.2109375 22.71875 15.21875 16.51953125 4.61328125 1.03125 0.7734375 0.6328125 Donor 20022 63.0078125 66.3359375 23.3984375 13.71875 14.7265625 3.30078125 1.3125 0.703125 0.4921875 Donor 20023 62.9609375 55.3203125 22.6953125 2.375 15.76953125 3.62890625 1.5 0.5859375 0.6796875 Donor 20024 58.296875 47.75 17.515625 18.4765625 17.29296875 3.95703125 0.75 0.3984375 0.5859375 Donor 20025 63.453125 55.7890625 17.639375 2 16.296875 3.74609375 1.359375 0.703125 0.5859375 Donor 20026 70.90625 65 26.1640625 3.72265625 15.13671875 6.4765625 2.1796875 0.8671875 0.75 Donor 20027 59.5625 54.5234375 22.4609375 16.00390625 15.76953125 4.90625 1.0078125 0.7265625 0.65625 Donor 20028 57.5703125 52.3671875 17.2578125 1.0625 14.99609375 2.75 1.078125 0.3984375 0.421875 Donor 20029 62.8203125 57.8984375 25.8828125 16.8359375 19.12109375 4.15625 1.171875 0.7265625 0.703125 Donor 20030 58.0390625 47.8671875 17.2109375 1.54296875 17.57421875 3.40625 1.2421875 0.3515625 0.421875 Donor 20031 57.59375 54.6875 15.8515625 12.734375 17.64453125 0.828125 1.265625 0.3984375 0.375 Donor 20032 68.046875 62.4921875 19.859375 20.84375 1.3125 0.65625 Donor 20033 57.8515625 60.643625 15.453125 13.58984375 15.125 3.4296875 0.9609375 0.65625 0.28125 Donor 20034 65.84375 55.859375 23.2578125 17.29296875 17.41015625 5.1640625 1.7109375 0.7265625 0.65625 Donor 20035 62.375 62.3515625 21.546875 15.48828125 16.80078125 2.84375 1.0078125 0.4453125 0.421875 Donor 20036 64.5546875 52.390625 21.9453125 1.91796875 12.25390625 5.0234375 1.5703125 0.4921875 0.609375 Donor 20037 63.078125 60.21875 23.234375 1.3671875 17.90234375 4.37890625 1.3125 0.4921875 0.3515625 Donor 20038 54.828125 51.96875 15.078125 14.05859375 14.45703125 4.8125 1.0546875 0.4453125 0.375 Donor 20039 59 54.4296875 16.8828125 1.8828125 16.75390625 2.3515625 1.265625 0.4453125 0.28125 Donor 20040 61.9296875 55.8828125 17.9609375 2.3984375 14.97265625 3.1484375 1.21875 0.6328125 0.515625 Donor 20041 69.546875 63.546875 22.0390625 3.5234375 17.36328125 4.44921875 1.78125 0.6328125 0.7265625 Donor 20042 60.7109375 49.6953125 19.53125 2.0703125 15.67578125 0.88671875 1.078125 0.3515625 0.5390625 Donor 20043 60.453125 58.4140625 19.765625 1.16796875 15.546875 4.70703125 1.1484375 0.515625 0.3984375 Donor 20044 54.8046875 43.2265625 18.1015625 12.7109375 15.60546875 70.47265625 0.9375 0.4453125 15.0703125 Donor 20045 57.8515625 55.34375 18.078125 12.6875 19.28515625 5.09375 0.890625 0.3984375 0.5625 Donor 20046 60.6875 55.7421875 21.03125 1.49609375 20.85546875 25.859375 1.1015625 0.4921875 4.640625 Donor 20047 67.9765625 59.84375 21.078125 9.55859375 17.31640625 3.6640625 1.3359375 0.4921875 0.375 Donor 20048 57.125 50.984375 15.921875 3.65234375 15.6758125 2.38671875 0.9140625 0.3984375 0.3515625 Donor 20049 65.984375 62.234375 22.2265265 1.5546875 17.0234375 4.51953125 1.3125 0.515625 0.5859375 Donor 20050 67.4140625 55.859375 27.9453125 3.20703125 18.8984375 5.75 1.7578125 0.46875 0.84375 Donor 20051 67.953125 57.875 23.140625 2.796875 12.7109375 4.390625 2.34375 0.46875 0.5625 Donor 20052 60.9453125 55.109375 17.3984375 1.82421875 21.5703125 2.48046875 1.1484375 0.375 0.3984375 Donor 20053 76.296875 71.3046875 31.3203125 12.93359375 21.21875 6.79296875 1.8984375 0.84375 0.8671875 Donor 20054 60.9921875 54.921875 20.2578125 1.58984375 19.015625 1.05078125 1.3359375 0.46875 0.9140625 Donor 20055 65.84375 58.53125 0.21875 2.45703125 17.22265625 0.171875 1.8515625 0.4453125 0.046875 Donor 20056 61.53125 53.5390625 18.265625 1.5078125 14.703125 3.27734375 1.078125 0.5625 0.3515625 Donor 20057 60.171875 55.8125 15.3125 2.10546875 19.58984375 2.375 1.2421875 0.3984375 0.234375 Donor 20058 59.796875 46.4609375 16.3671875 1.8125 15.5 6.41796875 0.9375 0.28125 0.3046875 Donor 20059 56.09375 49.1328125 13.7890625 1.765625 19.2265625 2.71484375 1.125 0.28125 0.2109375 Donor 20060 66.3359375 57.5703125 27.2421875 7.14453125 17.31640625 5.2578125 1.6171875 0.6796875 0.890625 Donor 20061 65.8671875 54.5234375 21.6640625 2.328125 12.16015625 3.8984375 1.40625 0.3984375 0.46875 Donor 20062 66.734375 60.3125 22.5078125 16.109375 18.37109375 3.96875 1.5 0.6328125 0.703125 Donor 20063 53.3984375 47.1640625 15.453125 1.34375 12.2421875 3.06640625 0.984375 0.28125 0.2578125 CRT dA CN dA CFF dA Integration Integration Integration to Acrit to Acrit to Acrit Patient ID CRT LY30 CN LY30 CFF LY30 CRT CL30 CN CL30 CFF C130 (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 20064 0.024833187 0.032159975 9.17E-04 0.945202052 0.930819316 0.998963014 22.01000977 123.6604614 13.46868896 20066 0.027227931 0.031155364 3.31533656 0.935930925 0.931338818 0.966231427 9.047241211 79.45422363 7.499816895 20067 0.057821358 0.036387622 −0.003856145 0.875837515 0.912442997 0.998925116 153.9547119 99.68444824 9.722900391 20068 0.028914749 0.022136074 0.014169329 0.942663379 0.943586865 0.969329073 10.61444092 73.97808838 16.71514893 20069 0.010409081 0.021366745 0.006801809 0.976786527 0.951659801 0.989883507 45.56744385 124.6541748 40.34179687 20070 0.02001886 0.01853278 0.021710115 0.954102921 0.954418734 0.959705373 177.7263794 85.78564453 12.21624756 20072B 0.032224503 0.015311278 0.026953188 0.932561583 0.955997392 0.947699758 15.43798828 37.31286621 7.895324707 20073D 0.031841081 0.023220757 0.009871479 0.929929013 0.94563859 0.988099531 289.40625 91.93579102 19.81658936 20074B 0.02866456 0.026303772 0.019107598 0.944695397 0.939642621 0.966643502 48.4118042 70.91455078 22.12207031 20075D 0.039951448 0.042670895 0.00504913 0.91142793 0.900385524 0.982697853 257.40802 91.57983398 22.74169922 20076B 0.043616073 0.01924223 0.02673753 0.917068718 0.951116476 0.950975942 48.6293335 54.76135254 6.827453613 20077D 0.04500375 0.009964381 0.014003905 0.931991849 0.969971595 0.979778527 136.005249 63.19555664 6.870300293 20078B 0.059638955 0.0397574 0.0332274142 0.883989428 0.90965251 0.935842601 8.946716309 65.0725708 9.99810791 20079D 0.066583796 0.051418454 0.01426999 0.872471191 0.883002925 0.969322539 76.22094727 55.92645264 11.32965088 20080B 0.049277595 0.023347729 0.020451634 0.905485951 0.944366823 0.956655395 245.0846558 83.91027832 20.39337158 20081D 0.016452223 −0.001491967 −0.00394093 0.962917182 0.988105563 1.00090799 47.89105225 83.4307251 22.50933838 20082B 0.036992942 0.028016378 0.008201792 0.922341024 0.936918896 0.984641638 5.176208496 68.65686035 9.922302246 20083B 0.014174326 0.007678877 −0.001578657 0.972196478 0.973359234 1.001045661 186.598938 67.07647705 24.83129883 20084D 0.033066897 0.02959325 0.01943336 0.926884422 0.937000406 0.959297686 140.1745605 82.28704834 9.225219727 20085D 0.041087168 0.023255641 −0.007493108 0.919830125 0.944328979 1.007089405 18.01373291 52.26830537 7.194946289 20086B 0.042433701 0.033799237 3.81E−04 0.920943657 0.927684758 0.994857731 17.7088623 62.7522583 22.92791748 20087D 0.022928927 0.017378819 −0.005552389 0.954458563 0.956338706 1.004885993 270.4449463 118.2469482 20.77075195 20088B 0.021815134 0.008897823 0.010444395 0.956643002 0.971822969 0.978704525 140.0905151 79.40148926 8.343566895 20090B 0.059329015 0.044530954 0.013343385 0.883988619 0.898667493 0.970599322 61.87060547 69.78076172 17.21282959 20091D 0.025758288 0.01940219 −0.007108577 0.942158476 0.952688439 1.004993342 23.20477295 110.65979 17.00518799 20092B 0.022125789 0.022683333 0.011923631 0.949278629 0.947741935 0.976224784 216.5800781 97.90631104 13.76202393 20093D 0.024585153 0.016145642 −0.009099425 0.94628821 0.957420776 1.012011087 367.4399414 79.46740723 33.99719238 20094B 0.014574856 0.012071477 0.009293042 0.965892772 0.969758836 0.987714073 31.93560791 106.9568481 10.24035645 20095D 0.027034079 0.008573037 −0.013358404 0.940491293 0.971485743 1.013734467 225.9354858 68.21191406 14.21026611 200961B 0.021996402 0.01234881 0.021483583 0.953874092 0.962285714 0.956222132 64.88140869 38.86523438 6.565429687 20097D 0.023692686 0.018750939 −0.004599629 0.949033517 0.959112413 1.005751534 171.539978 155.7394409 11.30657959 20098B 0.026020912 0.019252464 0.026261418 0.939470366 0.954015193 0.947803393 14.31903076 86.23718262 12.51617432 20099D 0.024551547 0.026462046 −0.013231336 0.941184316 0.943903081 1.002549936 102.4249878 61.70910645 5.507446289 201001B 0.040584392 0.078264405 0.032046362 0.915829888 0.853393196 0.933732684 13.95648193 77.07623291 60.44018555 20101D 0.03119636 0.027867496 0.009337058 0.933238453 0.933343143 0.98013245 12.74194336 72.55755615 14.88262939 201021B 0.03191815 0.032849106 −0.008873434 0.930960209 0.932446264 1.047819549 91.86328125 96.72802734 33.78460693 20103D 0.038131123 0.026895376 −0.007834213 0.922488965 0.93931732 1.020844914 201.2475586 169.8640137 34.12243652 201041B 0.035729727 0.014632895 0.007350707 0.926838016 0.969568893 0.993164341 198.9783325 154.1293945 34.80633545 20105D 0.044985779 0.024768064 −0.015139172 0.91278621 0.944054964 1.02688391 10.42987061 72.78662109 8.246337891 201061B 0.048066538 0.030807178 0.020493357 0.911639166 0.929827175 0.968201391 23.42230225 76.59503174 12.2244873 20108B 0.04610737 0.055939588 0.008846676 0.897693079 0.880924468 0.987056568 137.7454834 62.3303833 6.303405762 20109D 0.032723807 0.02958799 0.00963191 0.929873068 0.934539649 0.983839938 18.49822998 101.1774902 23.00372314 201101B 0.041664932 0.037481321 0.005831413 0.916296502 0.922748893 1.020737327 7.199890137 59.24377441 7.386108398 20111D 0.07380315 0.035058589 0.01398226 0.864779076 0.917244306 1.001260504 11.9262085 72.05822754 18.81628418 20112B 0.037126394 0.019984526 0.014676904 0.923516976 0.952426132 0.95193008 18.40759277 82.00195313 16.73822021 20113D 0.062763232 0.03286058 0.004612521 0.875330291 0.921362543 0.987467866 237.548584 95.33221436 17.81433105 201141B 0.024689651 0.02696704 0.001779683 0.944137094 0.937761194 0.99766173 108.7250977 63.23675537 14.72607422 20115B 0.026801432 0.019098248 0.010429078 0.937839545 0.957028943 0.974468085 14.66674805 84.22009277 12.0135498 20116D 0.041788659 0.012975699 0.012377694 0.909358289 0.957083906 0.970249901 18.28729248 61.83599854 10.85668945 201171B 0.036011244 0.027881581 0.035371179 0.924625208 0.941667933 0.929257642 121.7373047 69.22869873 10.15301514 20118D 0.020317437 0.023174715 0.007876845 0.95283237 0.951180717 0.987412587 61.04168701 121.1506348 17.87860107 20119B 0.02381942 0.007657879 0.021167605 0.952802704 0.974248927 0.955665025 174.1404419 97.82391357 15.67858887 20120D 0.040758131 0.023425042 0.010314535 0.918711478 0.945497321 0.980459376 222.6000366 91.41998291 29.78997803 20121B 0.031288949 0.032133624 0.009660442 0.924949563 0.926094891 0.98111624 136.7023315 108.9755859 13.52471924 20122D 0.035321697 0.027525692 −0.00513424 0.930216878 0.938090502 1.006276151 224.470459 72.49328613 22.86859131 20123B 0.033839427 0.088742387 0.008031119 0.9260297 0.828109899 0.987073609 15.44128418 58.38848877 19.63201904 20124D 0.055306995 0.057727962 0.02311456 0.892009191 0.893894922 0.948391922 25.14276123 102.321167 27.14172363 20125B 0.048024825 0.026111309 0.041437174 0.907468774 0.939272986 0.914453125 185.3300171 70.58001709 9.764099121 20126D 0.033167509 0.109710199 0.005837412 0.930638029 0.806567164 0.980798193 16.9821167 76.05615234 2.073120117 20127B 0.04030228 0.053709983 0.020658532 0.917356493 0.890892831 0.957644211 10.63256836 71.53088379 12.26733398 20128D 0.044331507 0.023482618 0.011477672 0.908703591 0.94196804 0.979113924 77.29376221 87.25891113 62.69952393 20129B 0 .034457501 0.028807898 0.023877814 0.930078985 0.933194774 0.95362083 142.3498535 57.01574707 13.45880127 20130D 0.023212202 0.007788533 6.96E−04 0.946803705 0.973520066 0.991686872 15.94061279 121.3665161 26.18920898 20131B 0.043807474 0.03083657 −0.006430128 0.91341592 0.92454226 1.003795867 55.03985596 35.0255127 11.60980225 20132D 0.042476997 0.025035029 0.005946626 0.915478499 0.94810511 0.985498489 82.80780029 70.1350708 23.00372314 20133B 0.012985918 −7.23E−04 −0.008082622 0.969643309 0.989008113 1.01077683 16.52893066 82.35131836 12.51617432 20134D 0.039836577 0.026127863 0.014341442 0.926115764 0.938416422 0.969037965 9.996459961 67.71917725 2.796569824 20135B 0.035194616 0.059814843 0.020118734 0.925877251 0.887523049 0.959291368 182.315918 75.27008057 17.15844727 20136D 0.022431653 0.022472166 0.01052529 0.951208178 0.953054013 0.979946524 33.27044678 85.70654297 25.14935303 20137B 0.037332155 0.030097212 0.024850274 0.921978799 0.931966618 0.947638604 4.075378418 52.4196167 6.858764648 20138D 0.047406693 0.023399896 0.005910018 0.901625792 0.938919342 0.985040798 10.56170654 57.3684082 9.422973633 20139B 0.041498688 0.031996581 0.017536114 0.912106538 0.922375654 0.968630185 39.67437744 95.60412598 27.92944336 20140D 0.527082853 1 1 0.951892017 1 1 31.40002441 142.3432617 32.80407715 20141B 0.047614967 0.032637805 0.027701912 0.904755784 0.925904897 0.939133828 28.31011963 79.32568359 17.22271729 20142D 0.022763142 0.033247165 −0.006142433 0.940590494 0.923549033 1.008902077 105.5742188 104.3069458 30.98803711 20144B 0.016424796 0.024664914 0.00211955 0.96092312 0.939220538 0.988824503 9.5 0314941 59.581604 8.468811035 20145D 0.029375317 0.029634449 −0.016528727 0.93724645 0.93797654 1.0215905 43.99200439 69.5994873 5.809020996 20146B 0.027744219 0.029046058 0.002625046 0.924523602 0.932832241 0.994483266 13.85925293 54.21258545 19.41119385 20147D 0.047133935 0.033383522 0.021421797 0.902052931 0.92160669 0.961078867 19.40130615 37.47930908 16.64099121 20148B 0.032600404 0.044176398 −0.343559739 0.9330305 0.904200899 0.003662165 20.50213623 66.52935791 105.208374 20149D 0.025634798 0.029747074 −0.008754644 0.946534653 0.929623038 1.00955414 15.53192139 31.12646484 9.361999512 20150B 0.037720365 0.054626687 0.027442979 0.922646658 0.894579439 0.939624329 14.42779541 21.01464844 0.685546875 20151D 0.04069884 0.036162788 0.015357235 0.922543032 0.919252692 0.964051024 8.215026855 44.57702637 12.90838623 20152B 0.043437785 0.035774447 0.033006757 0.909178082 0.914996545 0.929343629 16.7744751 76.15338135 22.21435547 20153D 0.029718283 0.03837133 0.001880856 0.936002008 0.924225029 0.990856756 13.03857422 54.78277588 10.1282959 20154B 0.041638581 0.039198078 0.019272149 0.914058739 0.915403146 0.964851826 318.8287354 86.66235352 18.76025391 20155D 0.029455731 0.023614407 0.016167408 0.938508187 0.944378523 0.974979149 21.53210449 61.49816895 22.1385498 20156A 0.031059307 0.040872574 −0.014663284 0.927195991 0.906458797 1.047601476 12.55407715 60.21936035 24.66815186 20157D 0.029935851 0.021280609 −0.009133877 0.934807766 0.943621868 1.012761432 35.09802246 53.40179443 10.31945801 20158B 0.038318779 0.033309691 0.023378903 0.922172524 0.926534269 0.952904239 154.956665 63.73443604 14.00262451 20159D 0.039985334 0.020185119 0.022336164 0.920236895 0.953084648 0.955547524 19.22662354 81.96734619 15.30944824 20160B 0.032691245 0.026974577 0.001812788 0.933920705 0.935587988 0.990112063 17.83410645 78.66485596 24.4720459 20161D 0.064456894 0.030047298 0.040432645 0.871404636 0.922920598 0.92300885 11.79602051 62.04528809 4.207214355 Donor 20003 0.028680127 0.027663862 0.002012601 0.938224414 0.944018516 1.002100105 36.47076416 130.2588501 31.66699219 Donor 20004 0.022439636 0.027468387 0.004736127 0.949672259 0.941397719 0.993250844 121.7158813 173.2653809 69.75274658 Donor 20005 0.029513579 0.045045639 −0.009513752 0.935257311 0.925318495 1.017681729 13.49505615 52.74261475 16.94586182 Donor 20006 0.030370554 0.042962748 0.006588498 0.933808078 0.904677485 0.996231156 93.28710938 104.8656006 26.24194336 Donor 20007 0.062782995 0.031328071 −0.007090395 0.88592372 0.927522306 1.017209909 136.1321411 100.861084 127.6237793 Donor 20008 0.03659895 0.02103815 0.00228 0.926134906 0.944477347 1 69.38360596 50.48657227 12.7633667 Donor 20009 0.038635312 0.026344331 0.012003968 0.931993628 0.939790178 0.986745214 26.43475342 68.25970459 12.85400391 Donor 2001 0.022351307 0.030189967 −0.010354148 0.949804592 0.93025433 1.014563107 198.2400513 54.50921631 6.537414551 Donor 20010 0.03470864 0.018110799 −0.006091718 0.931412713 0.952979447 1.009240246 205.680542 57.43432617 6.77142334 Donor 20011 0.024335519 0.019395001 −0.015828483 0.959181172 0.955430974 1.036013096 85.6307373 90.99481201 17.77807617 Donor 20012 0.027107937 0.026588214 0.026460089 0.939851689 0.939131611 0.947331461 46.95666504 66.31347656 14.10644531 Donor 20013 0.015684863 0.022569085 0.017489244 0.959803203 0.953108838 0.965679085 43.54870605 145.6160889 37.48260498 Donor 20014 0.041661201 0.025575032 0.007622836 0.912439878 0.940748056 0.985589913 23.54919434 83.30383301 20.16101074 Donor 20015 0.041298242 0.045100839 −0.002598719 0.920108187 0.915364887 1.011675991 137.0714722 186.5791626 61.12738037 Donor 20016 0.024066927 0.022948379 0.009179487 0.951688139 0.944407677 0.981538462 72.82287598 161.2765503 35.73248291 Donor 20017 0.061507734 0.03284789 .009612168 0.876927553 0.922907142 0.983359746 8.26940918 47.06707764 18.23291016 Donor 20018 0.018540503 0.013432926 6.21E−04 0.948958862 0.961740731 0.991014601 31.47253418 74.39666748 26.77258301 Donor 20019 0.016830896 0.001863276 0.010319222 0.963607401 0.980138429 0.981563674 203.8925171 49.21105957 9.816833496 Donor 2002 0.019869899 0.022142472 −0.001980694 0.954195323 0.952675416 1 18.73553467 102.4777222 24.4720459 Donor 20020 0.034770379 0.022890249 0.005045241 0.923536165 0.945176529 0.982903419 25.84313965 71.97912598 9.452636719 Donor 20021 0.040136879 0.03418404 0.004191025 0.911963883 0.918276581 0.992778542 146.1335449 111.3305054 27.13677979 Donor 20022 0.02218158 0.012441605 −0.00942404 0.956106634 0.968201625 1.012020033 169.1784668 89.15075684 14.34869385 Donor 20023 0.029469641 0.026219814 0.004001721 0.93634446 0.935602316 0.991738382 29.16210937 83.44390869 20.65704346 Donor 20024 0.052116278 0.047406741 0.024062717 0.890645939 0.892015707 0.961195361 133.9 23535 61.14385986 19.03216553 Donor 20025 0.018108054 0.024227855 9.74E−04 0.963432652 0.9453858 1.00931677 21.20251465 101.0687256 17.54901123 Donor 20026 0.029490629 0.033851162 3.04E−04 0.933891582 0.922115385 0.99820842 71.36773682 106.2877808 40.62194824 Donor 20027 0.040186145 0.061528036 0.030110145 0.917759706 0.895543774 0.937391304 156.7545776 100.9484253 31.09680176 Donor 20028 0.04236228 0.023107812 −0.008904859 0.928755598 0.942264658 1.014938886 7.016967773 48.56341553 8.37487793 Donor 20029 0.044844132 0.040235236 0.018316732 0.905981843 0.908514371 0.95834591 201.1849365 127.664978 23.58874512 Donor 20030 0.043891431 0.030500925 0.001550915 0.910755149 0.92704423 1.019064911 14.37835693 54.49603271 11.3939209 Donor 20031 0.014741025 −0.006701786 −0.01510391 0.962154097 0.995285714 1.019221291 110.5444336 62.43585205 1.911621094 Donor 20032 0.049918197 0.035924629 0.890815155 0.919364921 277.6662598 120.2178955 Donor 20033 0.031890427 0.096808526 0.049121587 0.93923025 0.819118784 0.925682508 117.9585571 65.63781738 9.043945313 Donor 20034 0.047260619 0.089839161 0.014281715 0.905671571 0.817062937 0.973799127 255.2492065 116.1359253 32.17785645 Donor 20035 0.019283358 −0.005776741 −0.009875816 0.955661323 0.996616965 1.011965192 144.1444702 61.64154053 9.44934082 Donor 20036 0.047403418 0.038066657 0.011970452 0.904877163 0.909633164 0.974368103 22.27532959 49.19952393 27.2109375 Donor 20037 0.058277943 0.028034546 0.018986307 0.889645777 0.942786715 0.96267653 11.84216309 80.40838623 14.2366333 Donor 20038 0.042141636 0.0278638 0.036417674 0.910230835 0.935057126 0.928497409 121.1358032 55.23760986 14.70629883 Donor 20039 0.041930762 0.023091598 −0.008177156 0.916181144 0.947036027 1.006941231 19.96325684 64.29473877 5.260253906 Donor 20040 0.027842956 0.110195606 0.0128806 0.942475085 0.823850133 0.972596781 25.91564941 84.21844482 11.01489258 Donor 20041 0.023519527 0.046152809 0.005627437 0.949786565 0.920334399 0.987238568 50.97766113 94.82794189 24.20013428 Donor 20042 0.031860264 0.006529372 0.022183333 0.935529533 0.97264581 0.9568 19.70288086 50.45526123 3.640319824 Donor 20043 0.028967433 0.025334916 −0.011353755 0.930214526 0.939414204 1.018972332 8.505065918 65.78942871 11.39227295 Donor 20044 0.114197553 0.158564522 0.025780463 0.788310763 0.718055305 0.948208891 36.30432129 52.46905518 297.8486938 Donor 20045 0.064360605 0.026431042 0.009035581 0.875219446 0.93393563 0.979256698 109.1832275 68.46405029 18.89208984 Donor 20046 0.032919778 0.024525812 0.003056897 0.929325438 0.938612474 0.989970282 12.31842041 83.62518311 52.18725586 Donor 20047 0.024480903 0.020561902 −0.009360329 0.945523503 0.946344648 1.010007413 105.4539185 64.4331665 10.7578125 Donor 20048 0.031785649 0.03008713 0.025537019 0.931892779 0.937480846 0.955839058 25.76898193 46.86273193 4.401672363 Donor 20049 0.020950088 0.005545443 0.003060926 0.958797064 0.977403967 0.989455185 14.84802246 76.41870117 25.08013916 Donor 20050 0.028353356 0.025734848 0.00905787 0.9426353 0.938741259 0.978194017 48.99188232 78.01721191 42.89941406 Donor 20051 0.04621832 0.0282808 −7.22E−04 0.908254771 0.933180346 0.994935854 50.53601074 44.65283203 23.11743164 Donor 20052 0.023606482 0.018178811 0.007644814 0.946545315 0.95151687 0.981140548 16.95574951 74.86303711 7.892028809 Donor 20053 0.028782681 0.025034087 0.008367285 0.943170182 0.947737482 0.989523572 252.0686646 150.3588867 48.98529053 Donor 20054 0.019195202 0.021942864 0.003445173 0.958883054 0.946230441 0.995372156 15.55169678 77.12072754 6.395690918 Donor 20055 0.016911387 0.006258898 0.355654762 0.959776934 0.975173518 0.571428571 35.99285889 65.85040283 0.009887695 Donor 20056 0.033615837 0.032245002 0.038925126 0.927628238 0.928206625 0.926860565 12.4354248 69.6159668 9.968444824 Donor 20057 0.023619226 −0.001850037 0.007844388 0.953648403 0.98656215 0.975510204 21.93255615 69.59454346 4.726318359 Donor 20058 0.037410178 0.021196962 0.009401352 0.919649856 0.942492013 0.978520286 14.59753418 35.77038574 8.762145996 Donor 20059 0.035590761 0.012877644 0.026754013 0.924791086 0.959453013 0.947308782 16.30810547 50.58544922 5.380554199 Donor 20060 0.039458937 0.027774951 0.004994742 0.916617595 0.937712037 0.989675939 84.71942139 89.47869873 40.0715332 Donor 20061 0.026452477 0.005382218 0.00186621 0.941999763 0.975497922 0.991345114 27.33288574 38.02313232 16.60803223 Donor 20062 0.037482927 0.023038104 0.01319565 0.922383517 0.944430052 0.975008678 244.914917 101.2318726 24.81811523 Donor 20063 0.037364667 0.016231848 0.011351955 0.918800293 0.948318701 0.975733064 9.897583008 26.38366699 6.593444824

TABLE 3 Patient ID CRT Amax (mm) CN Amax (mm) CFF Amax (mm) CRT Acrit (mm) CN Arit (mm) CFF Acrit (mm) CRT dAmax (mm) CN dAmax (mm) CFF dAmax (mm) CRT LY30 20150B 57.265625 41.796875 17.46875 1.61328125 15.2890625 0.40625 1.1484375 0.234375 0.375 0.037720365 20131B 59.28125 42.2421875 18.5234375 5.48046875 14.4453125 4.07421875 1.3359375 0.328125 0.3984375 0.043807474 20137B 55.2734375 43.0625 15.21875 0.83984375 18.55859375 2.75 0.8203125 0.3046875 0.328125 0.037332155 Donor 20044 54.8046875 43.2265625 18.1015625 12.7109375 15.60546875 70.47265625 0.9375 0.4453125 15.0703125 0.114197553 20152B 57.03125 45.21875 20.234375 1.80078125 20.76171875 4.2734375 1.1484375 0.3984375 0.5625 0.043437785 20100B 52.90625 45.2421875 20.8671875 1.49609375 15.91015625 3.1015625 1.3359375 0.5390625 2.203125 0.040584392 Donor 20058 59.796875 46.4609375 16.3671875 1.8125 15.5 6.41796875 0.9375 0.28125 0.3046875 0.037410178 20108B 54.5234375 46.6484375 16.296875 15.9453125 15.53515625 2.73828125 0.84375 0.4453125 0.2578125 0.04610737 Donor 20063 53.3984375 47.1640625 15.453125 1.34375 12.2421875 3.06640625 0.984375 0.28125 0.2578125 0.037364667 20110B 56.28125 47.6328125 16.953125 1.09765625 16.859375 2.796875 1.0078125 0.421875 0.328125 0.041664932 20153D 62.2578125 47.6328125 23.0703125 1.625 19.61328125 3.2890625 1.03125 0.3046875 0.421875 0.029718283 Donor 20024 58.296875 47.75 17.515625 18.4765625 17.29296875 3.95703125 0.75 0.3984375 0.5859375 0.052116278 Donor 20030 58.0390625 47.8671875 17.2109375 1.54296875 17.57421875 3.40625 1.2421875 0.3515625 0.421875 0.043891431 20072B 58.0390625 47.9375 16.1328125 1.71875 14.1875 3.37109375 1.125 0.328125 0.3046875 0.032224503 20079D 61.015625 48.078125 18.3359375 6.2421875 17.10546875 3.37109375 1.265625 0.3984375 0.3984375 0.066583796 20149D 63.125 48.2890625 19.625 1.56640625 14.046875 3.58203125 1.4296875 0.328125 0.3046875 0.25634798 20146B 62.7265625 48.8515625 21.2421875 1.484375 17.66796875 4.42578125 1.359375 0.3515625 0.4921875 0.027744219 20156A 59.234375 49.109375 21.171875 1.4140625 18.078125 4.82421875 1.3125 0.421875 0.7734375 0.031059307 Donor 20059 56.09375 49.1328125 13.7890625 1.765625 19.2265625 2.71484375 1.125 0.28125 0.2109375 0.35590761 20151D 56.28125 49.34375 20.2109375 1.14453125 16.671875 3.83984375 1.1484375 0.328125 0.3515625 0.04069884 Donor 20017 53.703125 49.5546875 19.71875 1.1796875 13.37890625 3.5703125 1.03125 0.3984375 0.5625 0.061507734 Donor 20042 60.7109375 49.6953125 19.53125 2.0703125 15.67578125 0.88671875 1.078125 0.3515625 0.5390625 0.031860264 20138D 56.703125 49.8828125 17.234375 1.33203125 23.1171875 2.8203125 1.1015625 0.28125 0.609375 0.047406693 Donor 2001 63.96875 50.0703125 17.703125 17.83203125 22.05078125 3.04296875 1.7109375 0.4453125 0.2578125 0.02235107 20148B 60.1953125 50.3984375 34.1328125 2.10546875 18.30078125 45.8515625 1.1015625 0.4453125 91.453125 0.032600404 20090B 60.40625 50.421875 20.7265625 6.03125 18.5703125 4.16796875 1.078125 0.46875 0.4921875 0.059329015 20144B 55.1796875 50.515625 18.875 1.47265625 16.33203125 2.69140625 0.7734375 0.3984375 0.3046875 0.016424796 20078B 56.1640625 50.5859375 18.265625 1.21484375 15.83984375 3.62890625 1.1015625 0.4921875 0.3046875 0.059638995 20135B 59.4453125 50.84375 20.7265625 14.984375 16.16796875 3.359375 1.21875 0.5390625 0.5625 0.035194616 Donor 20048 57.125 50.984375 15.921875 3.65234375 15.67578125 2.38671875 0.9140625 0.3984375 0.3515625 0.031785649 Donor 20009 63.7578125 51.3828125 21.21875 2.05859375 19.82421875 3.6640625 1.7109375 0.3984375 0.46875 0.038635312 20117B 56.28125 51.4296875 17.890625 12.125 18.55859375 2.92578125 0.984375 0.3984375 0.3984375 0.036011244 20076B 59.9140625 51.78125 17.2109375 5.45703125 16.2734375 2.24609375 1.0546875 0.375 0.3515625 0.04316073 Donor 20019 63.7578125 51.921875 22.8828125 18.79296875 17.9375 2.69140625 1.1015625 0.328125 0.4453125 0.016830896 Donor 20038 54.828125 51.96875 15.078125 14.05859375 14.45703125 4.8125 1.0546875 0.4453125 0.375 0.042141636 20066 57.40625 52.2265625 17.3515625 1.25 17.84375 2.29296875 0.984375 0.46875 0.3515625 0.027227931 20147D 63.171875 52.3203125 22.8828125 1.75390625 17.71484375 3.96875 1.5234375 0.3515625 0.46875 0.047133935 20158B 61.1328125 52.3203125 19.90625 15.8984375 18.98046875 3.51171875 0.9375 0.3984375 0.5859375 0.038318779 20114B 57.8984375 52.34375 20.046875 11.75 17.17578125 3.546875 0.890625 0.4453125 0.46875 0.024689651 20126D 61.8359375 52.34375 20.75 1.63671875 13.4375 0.6640625 1.4765625 0.703125 0.46875 0.033167509 Donor 20028 57.5703125 52.3671875 17.2578125 1.0625 14.99609375 2.75 1.078125 0.3984375 0.421875 0.04206228 Donor 20036 64.5546875 52.390625 21.9453125 1.91796875 12.25390625 5.0234375 1.5703125 0.4921875 0.609375 0.047403418 20127B 57.5703125 52.4140625 19.3671875 1.3203125 13.578125 3.7578125 1.171875 0.609375 0.46875 0.0403228 20106B 62.046875 52.4375 23.5859375 1.89453125 14.57421875 5.375 1.7578125 0.6328125 0.375 0.048066538 20085D 62.5390625 52.625 19.8359375 1.73046875 14.45703125 4.109375 1.3828125 0.4921875 0.28125 0.041087168 20129B 60.3359375 52.625 19.203125 10.5078125 14.703125 3.91015625 1.5 0.46875 0.4453125 0.034457501 20155D 64.4140625 52.671875 18.734375 1.9296875 19.90625 5.7265625 1.5 0.375 0.515625 0.029455731 Donor 20008 60.921875 52.765625 19.53125 11.7148375 19.1328125 3.86328125 1.0546875 0.328125 0.3984375 0.03659895 Donor 20010 59.1171875 52.8359375 15.21875 22.6015625 17.046875 3.16015625 1.21875 0.375 0.4453125 0.03470864 20115B 61.8359375 52.90625 18.359375 1.5546875 22.4375 3.40625 1.265625 0.421875 0.375 0.026801432 20101D 60.3828125 53.09375 18.875 1.4140625 16.44921875 3.76953125 1.359375 0.4921875 0.4453125 0.03119636 20124D 61.203125 53.234375 20.890625 2.08203125 18.3828125 9.59375 1.4765625 0.609375 0.375 0.055306995 20145D 61.625 53.28125 21.7109375 5.85546875 16.5546875 2.71484375 0.8671875 0.46875 0.3515625 0.029375317 Donor 20005 61.1796875 53.3515625 19.8828125 1.54296875 16.56640625 4.09765625 1.1484375 0.3515625 0.4921875 0.029513579 Donor 20056 61.53125 53.5390625 18.265625 1.5078125 14.703125 3.27734375 1.078125 0.5625 0.3515625 0.033615837 20161D 55.953125 53.8203125 17.65625 1.4609375 18.640625 1.98828125 1.03125 0.375 0.3046875 0.064456894 Donor 20003 63.359375 54.0078125 22.3203125 2.76171875 32.38671875 4.4609375 1.4765625 0.4453125 0.796875 0.028680127 20086B 62.2578125 54.125 22.7890625 1.859375 14.87890625 4.70703125 1.171875 0.4921875 0.5390625 0.042433701 Donor 20039 59 54.4296875 16.8828125 1.8828125 16.75390625 2.3515625 1.265625 0.4453125 0.28125 0.041930762 20159D 62 54.453125 21.6171875 1.89453125 20.31640625 4.484375 1.3359375 0.4453125 0.515625 0.039985334 Donor 20027 59.5625 54.5234375 22.4609375 16.00390625 15.76953125 4.90625 1.0078125 0.7265625 0.65625 0.040186145 Donor 20061 65.8671875 54.5234375 21.6640625 2.328125 12.16015625 3.8984375 1.40625 0.3984375 0.46875 0.026452477 20082B 55.53125 54.6171875 18.3125 0.93359375 14.5859375 3.06640625 0.9140625 0.515625 0.3515625 0.036992942 20096B 64.53125 54.6875 19.2734375 5.59765625 13.7421875 3.6875 1.1953125 0.421875 0.1875 0.021996402 Donor 20031 57.59375 54.6875 15.8515625 12.734375 17.64453125 0.828125 1.265625 0.3984375 0.375 0.014741025 20125B 61.296875 54.8046875 20 16.75390625 17.90234375 4.33203125 1.1015625 0.4921875 0.3984375 0.048024825 20157D 60.7578125 54.875 22.0390625 2.421875 13.19140625 3.21875 1.78125 0.4921875 0.46875 0.029935851 20088B 61.625 54.8984375 17.609375 19.33203125 19.8359375 2.99609375 0.9140625 0.421875 0.3046875 0.021815134 Donor 20054 60.9921875 54.921875 20.2578125 1.58984375 19.015625 1.05078125 1.3359375 0.46875 0.9140625 0.019195202 20141B 60.78125 55.0390625 20.0234375 2.50390625 19.25 4.30859375 1.2421875 0.46875 0.4453125 0.047614967 Donor 20052 60.9453125 55.109375 17.3984375 1.82421875 21.5703125 2.48046875 1.1484375 0.375 0.3984375 0.023606482 20154B 64.90625 55.1328125 22.671875 24.875 22.0625 3.6875 1.40625 0.421875 0.5625 0.041638581 20111D 61.53125 55.2265625 18.59375 1.37890625 16.484375 5.3046875 1.2890625 0.5 5625 0.46875 0.07380315 Donor 20023 62.9609375 55.3203125 22.6953125 2.375 15.76953125 3.62890625 1.5 0.5859375 0.6796875 0.029469641 Donor 20045 57.8515625 55.34375 18.078125 12.6875 19.28515625 5.09375 0.890625 0.3984375 0.5625 0.064360605 20068 63.359375 55.671875 24.453125 1.37890625 14.97265625 4.49609375 1.0546875 0.5859375 0.6328125 0.028914749 20160B 62.0703125 55.671875 23.703125 1.90625 17.99609375 4.8828125 1.171875 0.4921875 0.5625 0.032691245 20105D 60.734375 55.71875 19.1796875 1.26171875 22.0625 4.1796875 1.3359375 0.375 0.234375 0.044985779 Donor 20011 63.734375 55.7421875 21.4765625 3.8515625 16.00390625 4.8125 2.625 0.6796875 0.421875 0.024335519 Donor 20046 60.6875 55.7421875 21.03125 1.49609375 20.85546875 25.859375 1.1015625 0.4921875 4.640625 0.032919778 Donor 20025 63.453125 55.7890625 17.609375 2 16.296875 3.74609375 1.359375 0.703125 0.5859375 0.018108054 Donor 20057 60.171875 55.8125 15.3125 2.10546875 19.58984375 2.375 1.2421875 0.3984375 0.234375 0.023619226 Donor 20034 65.84375 55.859375 23.2578125 17.29296875 17.41015625 5.1640625 1.7109375 0.7265625 0.65625 0.047260619 Donor 20050 67.4140625 55.859375 27.9453125 3.20703125 18.8984375 5.75 1.7578125 0.46875 0.84375 0.028353356 Donor 20040 61.9296875 55.8828125 17.9609375 2.3984375 14.97265625 3.1484375 1.21875 0.6328125 0.515625 0.027842956 20070 61.7890625 56.046875 18.03125 14.01171875 17.6328125 3.58203125 1.1953125 0.5625 0.3984375 0.02001886 Donor 20021 58.8359375 56.2109375 22.71875 15.21875 16.51953125 4.61328125 1.03125 0.7734375 0.6328125 0.040136879 20083B 67.4375 56.3046875 22.4140625 17.10546875 21.06640625 4.6953125 1.2890625 0.3984375 0.609375 0.014174326 20123B 55.765625 56.5859375 21.7578125 1.578125 17.22265625 5.01171875 1.359375 0.4921875 0.6796875 0.033839427 20116D 58.4375 56.796875 19.6953125 1.70703125 17.08203125 2.9375 1.4765625 0.4453125 0.421875 0.041788659 Donor 20007 68.2109375 56.9140625 29.9609375 8.22265625 22.9765625 12.875 1.8984375 0.515625 1.3125 0.062782995 Donor 20006 66.921875 57.2890625 24.875 7.3671875 18.9921875 4.46093765 1.265625 0.65625 0.703125 0.030370554 Donor 20060 66.3359375 57.5703125 27.241875 7.14453125 17.31640625 5.2578125 1.6171875 0.6796875 0.890625 0.039458937 20064 62.4453125 57.59375 22.6015625 1.9296875 16.82421875 3.60546875 1.453125 0.8203125 0.5390625 0.024833187 20098B 61.953125 57.59375 17.9609375 1.66015625 20.1875 3.39453125 1.1015625 0.515625 0.3984375 0.026020912 20112B 62.8203125 57.640625 21.453125 1.71875 21.0078125 4.49609375 1.453125 0.421875 0.4921875 0.037126394 20084D 62.1875 57.6640625 19.578125 14.3984375 19.84765625 3.21875 1.078125 0.4453125 0.328125 0.033066897 20077D 61.34375 57.7578125 16.2265625 15.8515625 14.0234375 2.52734375 1.03125 0.515625 0.3515625 0.04530375 Donor 20012 56.890625 57.7578125 22.25 3.0078125 17.3984375 4.5078125 1.875 0.515625 0.328125 0.027107937 Donor 20051 67.953125 57.875 23.140625 2.796875 12.7109375 4.393625 2.34375 0.46875 0.5625 0.04621832 Donor 20029 62.8203125 57.8984375 25.8828125 16.8359375 19.12109375 4.15625 1.171875 0.7265625 0.703125 0.044844132 20139B 64.53125 58.2734375 22.4140625 2.76171875 20.3046875 5.140625 1.7578125 0.609375 0.609375 0.041498688 Donor 20043 60.453125 58.4140625 19.765625 1.16796875 15.546875 4.70703125 1.1484375 0.515625 0.3984375 0.028967433 Donor 20055 65.84375 58.53125 0.21875 2.45703125 17.22265625 0.171875 1.8515625 0.4453125 0.046875 0.016911387 20142D 65.09375 58.5546875 26.328125 6.6875 28.87109375 5.8203125 1.78125 0.4921875 0.75 0.022763142 20109D 62.1640625 58.71875 20.3346875 1.70703125 18.78125 4.68359375 1.5234375 0.609375 0.5390625 0.032723807 20074B 63.9921875 59.0234375 22.484375 5.33984375 13.6484375 3.8046875 1.1953125 0.65625 0.65625 0.028666456 Donor 20016 70.34375 59.0234375 25.390625 3.6640625 18.88671875 6.08984375 2.484375 0.9609375 0.7734375 0.024066927 20132D 68.4921875 59.1640625 25.859375 6.01953125 21.60546875 4.77734375 1.4765625 0.5393625 0.5859375 0.042476997 20099D 58.578125 59.328125 18.3828125 13.42578125 12.6875 3.546875 0.8203125 0.5625 0.1875 0.024551547 Donor 20018 61.53125 59.421875 20.8671875 2.515625 18.76953125 6.7109375 1.40625 0.4453125 0.421875 0.018540503 20133B 61.765625 59.703125 17.3984375 1.90625 17.6796875 3.34765625 1.03125 0.515625 0.3984375 0.012985918 20120D 67.1796875 59.7734375 22.7890625 14.48046875 17.64453125 5.19921875 1.4296875 0.5859375 0.6328125 0.040758131 Donor 20047 67.9765625 59.84375 21.078125 9.55859375 17.31640625 3.6640625 1.3359375 0.4921875 0.375 0.024480903 20121B 58.0859375 59.9375 18.6171875 13.30859375 14.3984375 3.08984375 1.1015625 0.890625 0.5390625 0.031288949 20067 59.2578125 59.9639375 21.8046875 16.15625 12.78125 2.609375 0.984375 0.890625 0.375 0.057821358 Donor 20037 63.078125 60.21875 23.234375 1.3671875 17.90234375 4.37890625 1.3125 0.4921875 0.3515625 0.058277943 Donor 20062 66.734375 60.3125 22.5078125 16.109375 18.37109375 3.96875 1.5 0.6328125 0.703125 0.037482927 20092B 69.3125 60.546875 21.6875 14.6328125 18.81640625 4.33203125 1.640625 0.6328125 0.3515625 0.022125789 Donor 20033 57.8515625 60.640625 15.453125 13.58984375 15.125 3.4296875 0.9609375 0.65625 0.28125 0.031890427 20102B 68.9140625 61.0625 25.9765625 6.5 19.8828125 5.99609375 1.5 0.5625 0.6796875 0.03191815 20094B 65.28125 61.2265625 20.984375 2.57421875 16.94140625 2.8203125 1.4765625 0.7265625 0.46875 0.014574856 20134D 62.4921875 61.2734375 21.1953125 1.25 15.44140625 0.79296875 1.265625 0.7734375 0.4921875 0.039836577 20080B 64.2265625 61.5078125 25.4140625 18.60546875 18.640625 4.63671875 1.2421875 0.65625 0.4921875 0.049277595 20113D 65.046875 61.6953125 24.3125 16.2734375 18.53515625 3.7578125 1.5 0.6328125 0.515625 0.062763232 20140D 67.71875 61.8828125 26.46875 2.3984375 18.8515625 5.5390625 1.640625 0.84375 0.703125 0.527082853 20136D 67.25 61.90625 23.375 2.26953125 18.5234375 5.10546875 1.9453125 0.515625 0.5390625 0.022431653 Donor 2002 56.796875 61.90625 20.7734375 1.73046875 13.91796875 4.25 1.4765625 0.9140625 0.609375 0.019869899 Donor 20049 65.984375 62.234375 22.2265625 1.5546875 17.0234375 4.51953125 1.3125 0.515625 0.5859375 0.020950088 Donor 20035 62.375 62.3515625 21.546875 15.48828125 16.80078125 2.84375 1.0078125 0.4453125 0.421875 0.019283358 20095D 67.7421875 62.46875 23.890625 17.45703125 17.703125 4.00390625 1.2890625 0.46875 0.3984375 0.027034079 Donor 20032 68.046875 62.4921875 19.859375 20.84375 1.3125 0.65625 0.049918197 20073D 68.234375 62.515625 21.6640625 20.4453125 18.2421875 4.33203125 1.3125 0.609375 0.5390625 0.031841081 20075D 69.59375 62.8233125 24.3828125 16.63671875 16.578125 5.421875 1.4765625 0.703125 0.5625 0.039951448 20122D 69.5234375 62.84375 26.140625 11.1171875 15.8984375 4.61328125 2.109375 0.5625 0.6796875 0.035321697 Donor 20020 68.046875 62.84375 26.046875 1.9765625 13.4375 2.234375 1.875 0.65625 0.796875 0.034770379 20091D 66.453125 62.9140625 23.46875 2.01171875 18.4765625 4.30859375 1.4765625 0.65625 0.4453125 0.025758288 20081D 69.5234375 63.0546875 25.8125 3.23046875 19.96484375 5.59765625 1.6171875 0.4921875 0.6328125 0.016452223 Donor 20014 71.46875 63.2890625 26.0234375 1.90625 18.171875 5.703125 1.734375 0.515625 0.5625 0.041661201 Donor 20041 69.546875 63.546875 22.0390625 3.5234375 17.36328125 4.44921875 1.78125 0.6328125 0.7265625 0.023519527 20119B 67.0390625 63.7109375 22.203125 13.87109375 17.66796875 4.0390625 1.2890625 0.6328125 0.421875 0.02381942 20093D 71.5625 63.8515625 25.3671875 19.625 17.1875 5.75 2.484375 0.5625 0.65625 0.024585153 20118D 67.578125 63.8515625 22.34375 3.55859375 16.7890625 3.58203125 1.8984375 0.796875 0.6328125 0.020317437 Donor 20004 70.3203125 64.390625 27.78125 7.14453125 24.78125 4.51953125 1.7109375 0.796875 3.8671875 0.022439636 20069 68.65625 64.484375 25.484375 2.85546875 15.828125 5.5390625 2.0390625 0.9375 0.84375 0.010409081 20104B 65.3515625 64.6953125 27.4296875 17.41015625 24.21875 7.68359375 1.0546875 0.703125 0.4921875 0.035729727 20087D 69.4765625 64.953125 23.984375 18.1015625 18.7578125 5.8671875 1.40625 0.796875 0.46875 0.022928927 Donor 20026 70.90625 65 26.1640625 3.72265625 15.13671875 6.4765625 2.1796875 0.8671875 0.75 0.029490629 20128D 64.1796875 65.0234375 24.6875 5.52734375 15.3125 11.26953125 1.5234375 0.75 0.6796875 0.044331507 Donor 20022 63.0078125 66.3359375 23.3984375 13.71875 14.7265625 3.30378125 1.3125 0.703125 0.4921875 0.02218158 20130D 69.171875 66.3828125 22.5546875 1.58984375 23.12890625 4.8828125 1.4296875 0.5859375 0.609375 0.023212202 Donor 20015 75.1015625 67.015625 32.1171875 5.33984375 23.48046875 7.96484375 2.8828125 0.9140625 1.0546875 0.041298242 20103D 72.5703125 67.9765625 28.109375 10.2734375 24.265625 6.359375 1.921875 0.796875 0.75 0.038131123 Donor 20013 74.6328125 67.9765625 26.6328125 2.515625 18.4765625 6.41796875 2.484375 0.984375 0.6796875 0.015684863 20097D 66.640625 69.359375 20.375 14.10546875 16.49609375 3.44140625 1.2421875 1.0078125 0.3984375 0.023692686 Donor 20053 76.296875 71.3046875 31.3203125 12.93359375 21.21875 6.79296875 1.8984375 0.84375 0.8671875 0.028782681 CRT dA Integration CN dA Integration CFF dA Integration Patient ID CN LY30 CFF LY30 CRT CL30 CN CL30 CFF CL30 to Acrit (mm{circumflex over ( )}2) to Acrit (mm{circumflex over ( )}2) to Acrit (mm{circumflex over ( )}2) CN Crit Prod 20150B 0.054626687 0.027442979 0.922646658 0.894579439 0.939624329 14.42779541 21.01464844 0.685546875 3.583374023 20131B 0.03083657 −0.006430128 0.91341592 0.92454226 1.003795867 55.03985596 35.0255127 11.60980225 4.739868164 20137B 0.030097212 0.024850274 0.921978799 0.931966618 0.947638604 4.075378418 52.4196167 6.858764648 5.654571533 Donor 20044 0.158564522 0.025780463 0.78810773 0.718055305 0.948208891 36.30432129 52.46905518 297.8486938 6.949310303 20152B 0.035774447 0.03306757 0.909178082 0.914996545 0.929343629 16.7744751 76.15338135 22.21435547 8.272247314 20100B 0.078264405 0.032046362 0.915829888 0.853393196 0.933732684 13.95648193 77.07623291 60.44018555 8.576568604 Donor 20058 0.021196962 0.009401352 0.919649856 0.942492013 0.978520286 14.59753418 35.77038574 8.762145996 4.359375 20108B 0.055939588 0.008846676 0.897693079 0.880924468 0.987056568 137.7454834 62.3303833 6.303405762 6.917999268 Donor 20063 0.016231848 0.011351955 0.918800293 0.948318701 0.975733064 9.897583008 26.38366699 6.593444824 3.443115234 20110B 0.037481321 −0.005831413 0.916296502 0.922748893 1.020737327 7.199890137 59.24377441 7.386108398 7.112548828 20153D 0.03837133 0.001880856 0.936002008 0.924225029 0.990856756 13.03857422 54.78277588 10.1282959 5.975921631 Donor 20024 0.047406741 0.024062717 0.890645939 0.892015707 0.961195361 133.9123535 61.14385986 19.03216553 6.890167236 Donor 20030 0.030500925 0.001550915 0.910755149 0.92704423 1.019064911 14.37835693 54.49603271 11.3939209 6.178436279 20072B 0.015311278 0.026953188 0.932561583 0.955997392 0.947699758 15.43798828 37.31286621 7.895324707 4.655273438 20079D 0.051418454 0.01426999 0.872471191 0.883002925 0.969322539 76.22094727 55.92645264 11.32965088 6.815460205 20149D 0.029747074 −0.008754644 0.946532653 0.0929623038 1.00955414 15.53192139 31.12646484 9.361999512 4.609130859 20146B 0.029046058 0.002625046 0.924523602 0.932832241 0.994483266 13.85925293 54.21258545 19.41119385 6.211395264 20156A 0.040872574 −0.014663284 0.927105991 0.906458797 1.047601476 12.55407715 60.21936035 24.66815186 7.626708984 Donor 20059 0.012877644 0.026754013 0.924791086 0.959453013 0.947308782 16.30810547 50.58544922 5.380554199 5.407470703 20151D 0.036162788 0.015357235 0.922543032 0.919252692 0.964051024 8.215026855 44.57702637 12.90838623 5.470458984 Donor 20017 0.03284789 0.009612168 0.876927553 0.922907142 0.983359746 8.26940918 47.06707764 18.23291016 5.330657959 Donor 20042 0.006529372 0.022183333 0.935529533 0.97264581 0.9568 19.70288086 50.45526123 3.640319824 5.511016846 20138D 0.023399896 0.005910018 0.901625792 0.938919342 0.985040798 10.56170654 57.3684082 9.422973633 6.501708984 Donor 2001 0.030189967 −0.010354148 0.949804592 0.93025433 1.014563107 198.2400513 54.50921631 6.537414551 9.819488525 20148B 0.044176398 −0.343559739 0.9330305 0.904200899 0.003662165 20.50213623 66.52935791 105.208374 8.14956665 20090B 0.044530954 0.013343385 0.883988619 0.898667493 0.970599322 61.87060547 69.78076172 17.21282959 8.704833984 20144B 0.024664914 0.00211955 0.96092312 0.939220538 0.988824503 9.510314941 59.581604 8.468811035 6.507293701 20078B 0.0397574 0.032274142 0.8883989428 0.90965251 0.935842601 8.946716309 65.0725708 9.99810791 7.796173096 20135B 0.059814843 0.020118734 0.925877251 0.887523049 0.959291368 182.315918 75.27008057 17.15844727 8.715545654 Donor 20048 0.03008713 0.025537019 0.931892779 0.937480846 0.955839058 25.76898193 46.86273193 4.401672363 6.245819092 Donor 20009 0.026344331 0.012003968 0.931993628 0.939790178 0.986745214 26.43475342 68.25970459 12.85400391 7.898712158 20117B 0.027881581 0.035371179 0.924625208 0.941667933 0.929257642 121.7373047 69.22869873 10.15301514 7.394439697 20076B 0.01924223 0.02673753 0.917068718 0.951116476 0.950975942 48.6293335 54.76135254 6.827453613 6.102539063 Donor 20019 0.001863276 0.010319222 0.963607401 0.980138429 0.981563674 203.8925171 49.21105957 9.816833496 5.885742188 Donor 20038 0.278638 0.036417674 0.910230835 0.935057126 0.928497409 121.1358032 55.23760986 14.70629883 6.437896729 20066 0.031155364 0.01533656 0.939500925 0.931338818 0.966231427 9.047241211 79.45422363 7.499816895 8.364257813 20147D 0.033383522 0.021421797 0.902052931 0.92160669 0.961078867 19.40130615 37.47930908 16.64099121 6.227874756 20158B 0.033309691 0.023378903 0.922172524 0.926534269 0.952904239 154.956665 63.73443604 14.00262451 7.562530518 20114B 0.02696704 0.001779683 0.944137094 0.937761194 0.99766173 108.7250977 63.23675537 14.72607422 7.648590088 20126D 0.109710199 0.005837412 0.930638029 0.806567164 0.980798193 16.9821167 76.05615234 2.073120117 9.448242188 Donor 20028 0.023107812 −0.008904859 0.928755598 0.942264658 1.014938886 7.016967773 48.56341553 8.37487793 5.975006104 Donor 20036 0.038066657 0.011970452 0.904877163 0.909633164 0.974368103 22.27532959 49.19952393 27.2109375 6.031219482 20127B 0.053709983 0.020658532 0.917356493 0.890892831 0.957644211 10.63256836 71.53088379 12.26733398 8.274169922 20106B 0.030807178 0.020493357 0.911609166 0.929827175 0.968201391 23.42230225 76.59503174 12.2244873 9.222747803 20085D 0.023255641 −0.007493108 0.919800125 0.944328979 1.007089405 18.01373291 52.26800537 7.194946289 7.115570068 20129B 0.028807898 023877814 0.930078985 0.933194774 0.95362083 142.3498535 57.01574707 13.45880127 6.892089844 20155D 0.023614407 0.016167408 0.938508187 0.944378523 0.974979149 21.53210449 61.49816895 22.1385498 7.46484375 Donor 20008 0.02103815 0.00228 0.926134906 0.944477347 1 69.38360596 50.48657227 12.7633667 6.277954102 Donor 20010 0.018110799 −0.006091718 0.931412713 0.952979447 1.009240246 205.680542 57.43432617 6.77142334 6.392578125 2011513 0.019098248 0.010429078 0.937839545 0.957028943 0.974468085 14.66674805 84.22009277 12.0135498 9.465820313 201010 0.027867496 0.009337058 0.933238453 0.933343143 0.98013245 12.74194336 72.55755615 14.88262939 8.096399854 20124D 0.057727962 0.02311456 0.892039191 0.893894922 0.948391922 25.14276123 102.321167 27.14172363 11.20202637 20145D 0.029634449 −0.016528727 0.93724645 0.93797654 1.0215905 43.99200439 69.5994873 5.809020996 7.760009766 Donor 20005 0.045045639 −0.009513752 0.935257311 0.925318495 1.017681729 13.49505615 52.74261475 16.94586182 5.824127197 Donor 20056 0.032245002 0.038925126 0.927628238 0.928206625 0.926860565 12.4354248 69.6159668 9.968444824 8.270507813 201610 0.030047298 0.040432645 0.871404636 0.922920598 0.92300885 11.79602051 62.04528809 4.207214355 6.990234375 Donor 20003 0.027663862 0.002012601 0.938224414 0.944018516 1.002100105 36.47076416 130.2588501 31.66699219 14.42221069 2008613 0.033799237 3.81E−04 0.920943657 0.927684758 0.994857731 17.7088623 62.7522583 22.92791748 7.32321167 Donor 20039 0.023091598 −0.008177156 0.916181144 0.947036027 1.006941231 19.96325684 64.29473877 5.260253906 7.460723877 20159D 0.020185119 0.022336164 0.920236895 0.953084648 0.955547524 19.22662354 81.96734619 15.30944824 9.047149658 Donor 20027 0.061528036 0.030110145 0.917759706 0.895543774 0.937391304 156.7545776 100.9484253 31.09680176 11.45755005 Donor 20061 0.005382218 0.00186621 0.941999763 0.975497922 0.991345114 27.33288574 38.02313232 16.60803223 4.845062256 20082B 0.028016378 0.008201792 0.922341024 0.936918896 0.984641638 5.176208496 68.65686035 9.922302246 7.520874023 20096B 0.01234881 0.021483583 0.953874092 0.962285714 0.956222132 64.88140869 38.86523438 6.565429687 5.797485352 Donor 20031 −0.006701786 −0.01510391 0.962154097 0.995285714 1.019221291 110.5444336 62.43585205 1.911621094 7.03024292 2012513 0.026111309 0.041437174 0.907468774 0.939272986 0.914453125 185.3300171 70.58001709 9.764099121 8.811309814 201570 0.021280609 −0.009133877 0.934807766 0.943621868 1.012761432 35.09802246 53.40179443 10.31945801 6.492645264 200888 0.008897823 0.010444395 0.956643002 0.971822969 0.978704525 140.0905151 79.40148926 8.343566895 8.368286133 Donor 20054 0.021942864 0.003445173 0.958883054 0.946230441 0.995372156 15.55169678 77.12072754 6.395690918 8.913574219 20141B 0.032637805 0.027701912 0.904755784 0.925904897 0.939133828 28.31011963 79.32568359 17.22271729 9.0234375 Donor 20052 0.018178811 0.007644814 0.946545315 0.95151687 0.981140548 16.95574951 74.86303711 7.892028809 8.088867188 20154B 0.039198078 0.019272149 0.914058739 0.915403146 0.964851826 318.8287354 86.66235352 18.76025391 9.307617188 20111D 0.035058589 0.01398226 0.864779076 0.917244306 1.001260504 11.9262085 72.05822754 18.81628418 8.499755859 Donor 20023 0.026219814 0.004001721 0.93634446 0.935602316 0.991738382 29.16210937 83.44390869 20.65704346 9.239959717 Donor 20045 0.026431042 0.009035581 0.875219446 0.93393563 0.979256698 109.1832275 68.46405029 18.89208984 7.683929443 20068 0.022136074 0.014169329 0.942663379 0.943586865 0.969329073 10.61444092 73.97808838 16.71514893 8.773040771 20160B 0.026974577 0.001812788 0.933920705 0.935587988 0.990112063 17.83410645 78.66485596 24.4720459 8.857452393 20105D 0.024768064 −0.015139172 0.91278621 0.944054964 1.02688391 10.42987061 72.78662109 8.246337891 8.2734375 Donor 20011 0.019395001 −0.015828483 0.959181172 0.955430974 1.036013096 85.6307373 90.99481201 17.77807617 10.87765503 Donor 20046 0.024525812 0.003056897 0.929325438 0.938612474 0.989970282 12.31842041 83.62518311 52.18725586 10.26480103 Donor 20025 0.024227855 9.74E−04 0.963432652 0.9453858 1.00931677 21.20251465 101.0687256 17.54901123 11.45874023 Donor 20057 −0.001850037 0.007844388 0.953648403 0.98656215 0.975510204 21.93255615 69.59454346 4.726318359 7.805328369 Donor 20034 0.089839161 0.014281715 0.905671571 0.817062937 0.973799127 255.2492065 116.1359253 32.17785645 12.64956665 Donor 20050 0.025734848 0.009057087 0.9426353 0.938741259 0.978194017 48.99188232 78.01721191 42.89941406 8.858642578 Donor 20040 0.110195606 0.0128806 0.942475085 0.823850133 0.972596781 25.91564941 84.21844482 11.01489258 9.474884033 20070 0.01853278 0.021710115 0.954102921 0.954418734 0.959705373 177.7263794 85.78564453 12.21624756 9.918457031 Donor 20021 0.03418404 0.004191025 0.911963883 0.918276581 0.992778542 146.1335449 111.3305054 27.13677979 12.77682495 20083B 0.007678877 −0.001578657 0.972196478 0.973359234 1.001045661 186.598938 67.07647705 24.83129883 8.39364624 20123B 0.088742387 0.008031119 0.9260297 0.828109899 0.987073609 15.44128418 58.38848877 19.63201904 8.476776123 20116D 0.012975699 0.012377694 0.909358289 0.957083906 0.970249901 18.28729248 61.83599854 10.85668945 7.606842041 Donor 20007 0.031328071 −0.007090395 0.88592372 0.927522306 1.017209909 136.1321411 100.861084 127.6237793 11.84729004 Donor 20006 0.042962748 0.006588498 0.933838078 0.904677485 0.996231156 93.28710938 104.8656006 26.24194336 12.46362305 Donor 20060 0.027774951 0.004994742 0.916617595 0.937712037 0.989675939 84.71942139 89.47869873 40.0715332 11.76974487 20064 0.032159975 9.17E−04 0.945202052 0.930819316 0.998963014 22.01000977 123.6604614 13.46868896 13.80111694 20098B 0.019252464 0.026261418 0.939470366 0.954015193 0.947803393 14.31903076 86.23718262 12.51617432 10.40917969 20112B 0.019984526 0.014676904 0.923516976 0.952426132 0.95193008 18.40759277 82.00195313 16.73822021 8.862670898 20084D 0.02959325 0.01943336 0.926884422 0.937000406 0.959297686 140.1745605 82.28704834 9.225219727 8.838409424 20077D 0.009964381 0.014003905 0.931991849 0.969971595 0.979778527 136.005249 63.19555664 6.870300293 7.230834961 Donor 20012 0.026588214 0.026460089 0.939851689 0.939131611 0.947331461 46.95666504 66.31347656 14.10644531 8.971369336 Donor 20051 0.0282808 −7.22E−04 0.908254771 0.933180346 0.994935854 5153601074 44.65283203 23.11743164 5.958251953 Donor 20029 0.040235236 0.0118316732 0.905981843 0.908514371 0.95834591 201.1849365 127.664978 23.58874512 13.89266968 20139B 0.031996581 0.017536114 0.912106538 0.922375654 0.968630185 39.67437744 95.60412598 27.92944336 12.37316895 Donor 20043 0.025334916 −0.011353755 0.930214526 0.939414204 1.018972332 8.505065918 65.78942871 11.39227295 8.016357422 Donor 20055 0.006258898 0.355654762 0.959776934 0.975173518 0.571428571 35.99285889 65.85040283 0.009887695 7.669464111 20142D 0.033247165 −0.006142433 0.940590494 0.923549033 1.008902077 105.5742188 104.3069458 30.98803711 14.20999146 20109D 0.02958799 0.00963191 0.929873068 0.934539649 0.983839938 18.49822998 101.1774902 23.00372314 11.44482422 20074B 0.026303772 0.019107598 0.944695397 0.939642621 0.966643502 48.4118042 70.91455078 22.12207031 8.956787109 Donor 20016 0.022948379 0.009179487 0.951688139 0.944407677 0.981538462 72.82287598 161.2765503 35.73248291 18.1489563 20132D 0.025035029 0.005946626 0.915478499 0.94810511 0.985498489 82.80786029 70.1350708 23.00372314 11.646698 20099D 0.026462046 −0.013231336 0.941184316 0.943903081 1.002549936 102.4249878 61.70910645 5.507446289 7.13671875 Donor 20018 0.013432926 6.21E0−4 0.948958862 0.961740731 0.991014601 31.47253418 74.39666748 26.77258301 8.358306885 20133B −7.23E−34 −0.008082622 0.969643309 0.989008113 1.01077683 16.52893066 82.35131836 12.51617432 9.116088867 20120D 0.023425042 0.010314535 0.918711478 0.945497321 0.980459376 222.6000366 91.41998291 29.78997803 10.33859253 Donor 20047 0.020561902 −0.009360329 0.945523503 0.946344648 1.010007413 105.4539185 64.4331665 10.7578125 8.522918701 20121B 0.032133624 0.009660442 0.924949563 0.926094891 0.98111624 136.7023315 108.9755859 13.52471924 12.8236084 20067 0.036387622 −0.003856145 0.875807515 0.912442997 0.998925116 153.9547119 99.68444824 9.722900391 11.38330078 Donor 20037 0.028034546 0.018986307 0.889645777 0.942786715 0.96267653 11.84216309 80.40838623 14.2366333 8.811309814 Donor 20062 0.023038104 0.01319565 0.922383517 0.944430052 0.975008678 244.914917 101.2318726 24.81811523 11.62545776 20092B 0.022683333 0.011923631 0.949278629 0.947741935 0.976224784 216.5800781 97.90631104 13.76202393 11.90725708 Donor 20033 0.096808526 0.049121587 0.93923025 0.819118784 0.925682508 117.9585571 65.63781738 9.043945313 9.92578125 20102B 0.032849106 −0.008873434 0.930960209 0.932446264 1.047819549 91.86328125 96.72802734 33.78460693 11.18408203 20094B 0.012071477 0.009293042 0.965892772 0.969758836 0.987714073 31.93560791 106.9568481 10.24035645 12.30899048 20134D 0.026127863 0.014341442 0.926115764 0.938416422 0.969037965 9.996459961 67.71917725 2.796569824 11.94296265 20080B 0.023347729 0.020451634 0.905485951 0.944366823 0.956655395 245.0846558 83.91027832 20.39337158 12.23291016 20113D 0.03286058 0.004612521 0.875330291 0.921362543 0.987467866 237.548584 95.33221436 17.81433105 11.72927856 20140D 1 1 0.951892017 1 1 31.40002441 142.3432617 32.80407715 15.90600586 20136D 0.022472166 0.01052529 0.951208178 0.953054013 0.979946524 33.27044678 85.70654297 25.14935303 9.551147461 Donor 2002 0.022142472 −0.001980694 0.954195323 0.952675416 1 18.73553467 102.4777222 24.4720459 12.72189331 Donor 20049 0.005545443 0.003060926 0.958797064 0.977403967 0.989455185 14.84802246 76.41870117 25.08013916 8.777709961 Donor 20035 −0.005776741 −0.009875816 0.955661323 0.996616965 1.011965192 144.1444702 61.64154053 9.44934082 7.4815979 20095D 0.008573037 −0.013358404 0.940491293 0.971485743 1.013734467 225.9354858 68.21191406 14.21026611 8.298339844 Donor 20032 0.035924629 0.890815155 0.919364921 277.6662598 120.2178995 13.67871094 20073D 0.023220757 0.009871479 0.929929013 0.94563859 0.988099531 289.40625 91.93579102 19.81658936 11.11633301 20075D 0.042670895 0.00504913 0.91142793 0.900385524 0.982697853 257.40802 91.57983398 22.74169922 11.65649414 20122D 0.027525692 −0.00513424 0.930216878 0.938090502 1.006276151 224.470459 72.49328613 22.86859131 8.942871094 Donor 20020 0.022890249 0.005045241 0.923536165 0.945176529 0.982903419 25.84313965 71.97912598 9.452636719 8.818359375 20091D 0.01940219 −0.007108577 0.942158476 0.952688439 1.004993342 23.20477295 110.65979 17.00518799 12.12524414 20081D -0.001491967 −0.00394093 0.962917182 0.988105563 1.00090799 47.89105225 83.4307251 22.50933838 9.826446533 Donor 20014 0.025575032 0.007622836 0.912439878 0.940748056 0.985589913 23.54919434 83.30383301 20.16101074 9.369873047 Donor 20041 0.046152809 0.005627437 0.949786565 0.920334399 0.987238568 50.97766113 94.82794189 24.20013428 10.98770142 20119B 0.007657879 0.021167605 0.952802704 0.974248927 0.955665025 174.1404419 97.82391357 15.67858887 11.18051147 20093D 0.016145642 −0.009099425 0.94628821 0.957420776 1.012011087 367.4399414 79.46740723 33.99719238 9.66796875 20118D 0.023174715 0.007876845 0.95283237 0.951180717 0.987412587 61.04168701 121.1506348 17.87860107 13.37878418 Donor 20004 0.027468387 0.004736127 0.949672259 0.941397719 0.993250844 121.7158813 173.2653809 69.75274658 19.74755859 20069 0.021366745 0.006801809 0.976786527 0.951659801 0.989883507 45.56744385 124.6541748 40.34179687 14.83886719 20104B 0.014632895 0.007350707 0.926838016 0.969568893 0.993164341 198.9783325 154.1293945 34.80633545 17.02880859 20087D 0.017378819 −0.005552389 0.954458563 0.956338706 1.004885993 270.4449463 118.2469482 20.77075195 14.94763184 Donor 20026 0.033851162 3.04E−04 0.933891582 0.922115385 0.99820842 71.36773682 106.2877808 40.62194824 13.12637329 20128D 0.023482618 0.011477672 0.908733591 0.94196804 0.979113924 77.29376221 87.25891113 62.69952393 11.484375 Donor 20022 0.012441605 −0.00942404 0.956106634 0.968201625 1.012020033 169.1784668 89.15075684 14.34869385 10.35461426 20130D 0.007788533 6.96E−04 0.946833705 0.973520066 0.991686872 15.94061279 121.3665161 26.18920898 13.55209351 Donor 20015 0.0451000839 −0.002598719 0.920108187 0.915364887 1.011675991 137.0714722 186.5791626 61.12738037 21.46261597 20103D 0.026895376 −0.007834213 0.922488965 0.93931732 1.020844914 201.2475586 169.8640137 34.12243652 19.33666992 Donor 20013 0.022569085 0.017489244 0.959833203 0.953108838 0.965679085 43.54870605 145.6160889 37.48260498 18.18786621 20097D 0.018750939 −0.004599629 0.949003517 0.959112413 1.005751534 171.539978 155.7394409 11.30657959 16.62496948 Donor 20053 0.025034087 0.008367285 0.943170182 0.947737482 0.989523572 252.0686646 150.3588867 48.98529053 17.90332031

TABLE 4 CRT Amax CN Amax CN + 75tPA Amax CN + 150tPA Amax CFF Amax CFF + TXA Amax CRT Acrit Patient ID (mm) (mm) (mm) (mm) (mm) (mm) (mm) 10027 55.7421875 58.625 43.1328125 19.3203125 19.015625 16.859375 0.86328125 10036 44.75 28.953125 5.703125 4.578125 11.703125 13.578125 1.25 10013 40.671875 42.9453125 18.0546875 13.203125 18.21875 17.9140625 1.73046875 10099 31.0859375 10.7421875 3.2421875 0.921875 9.96875 5.9609375 0.76953125 10107 52.3203125 42.734375 30.9453125 22.6484375 16.0390625 16.5546875 1.625 10093 51.125 54.8984375 40.5546875 26.3046875 12.3828125 13.6484375 1.53125 10044 21.6171875 20.984375 14.0703125 2.1171875 4.5546875 9.453125 0.59375 10068 47.84375 48.3359375 33.03125 15.9296875 7.4140625 10.8359375 12.48828125 10030 61.2265625 64.5078125 47.2578125 33.59375 22.015625 23.421875 1.8359375 10077 52.6015625 55.484375 51.0546875 40.765625 16.2265625 15.8046875 1.82421875 10016 28.1796875 28.5546875 14.0703125 6.5234375 16.8828125 12.265625 1.49609375 10075 46.203125 53.421875 44.8671875 27.6640625 21.0078125 19.7421875 3.04296875 10090 46.671875 45.6171875 31.859375 19.15625 9.0546875 10.203125 5.05859375 10059 60.6875 55.5546875 41.4453125 30.265625 15.1953125 18.03125 1.16796875 10061 52.8359375 58.7421875 55.15625 33.9921875 23.3046875 22.2734375 15.78125 10097 50.5859375 56.7265625 52.6953125 32.1171875 19.1328125 16.8828125 1.16796875 10025 62.234375 70.203125 64.4375 51.8984375 22.765625 23.1640625 1.9296875 10050 53.4453125 59.8671875 53.9375 32.9609375 19.9765625 18.921875 12.03125 10060 61.7890625 46.2734375 54.5 38.1171875 23 15.1484375 1.7890625 10032 59.7734375 61.6953125 52.6015625 45.9921875 20.9140625 19.4140625 12.76953125 10106 33.5 36.5 30.40625 12.453125 6.875 6.546875 0.9921875 10063 48.59375 64.7890625 63.3828125 53.375 23.0234375 21.640625 1.35546875 10088 63.5 59.984375 60.8046875 49.9296875 20.6796875 20.5625 13.51953125 10102 55.25 61.34375 48.4765625 22.6953125 10.71875 11.0703125 14.0703125 10115 72.5703125 70.5546875 68.7734375 51.5 27.8046875 27.640625 12.91015625 10014 62.515625 65.0234375 62.3046875 49.578125 18.640625 22.3671875 1.7421875 10085 64.0390625 69.453125 65.9609375 58.3671875 21.8984375 21.7109375 1.68359375 10047 62.703125 69.171875 61.015625 42.3828125 23.8203125 24.59375 10.44921875 10051 66.078125 68.65625 66.1015625 38.2109375 25.15625 24.078125 2.0703125 10056 61.859375 70.6015625 58.90625 52.4609375 25.578125 28.4609375 2.9609375 10057 67.5078125 68.1640625 64.15625 57.03125 25.6015625 26.46875 3.2421875 10039 65.09375 67.1796875 62.84375 56.2109375 21.96875 22.0859375 2.38671875 10067 58.484375 61.1328125 52.7890625 44.609375 22.203125 21.8046875 16.5546875 10071 55.2265625 56.703125 0.125 19.9765625 14.234375 13.390625 0.79296875 10104 64.4609375 68 64.0859375 65.6796875 27.171875 26.234375 2.890625 10001 56.84375 55.625 52.2265625 41.75 21.1953125 20.28125 1.73046875 10002 63.03125 64.2734375 63.921875 58.203125 26.28125 25.578125 17.9375 10003 66.6875 67.53125 60.8046875 44.6796875 26.2578125 25.0859375 6.0546875 10004 46.203125 34.203125 22.7890625 16.6015625 14.9609375 20.984375 0.828125 10005 56.5625 60.359375 58.7890625 47.796875 27.5234375 26.2578125 1.3203125 10006 63.8515625 62.2109375 59.0234375 39.4765625 23.7265625 23.4921875 1.8828125 10007 61.953125 65.5625 59.3515625 52.296875 35.75 25.0625 2.140625 10008 70.1796875 60.734375 48.5703125 35.703125 32.46875 27.640625 6.11328125 10009 71.5390625 70.4375 65.9609375 48.828125 29.5859375 29.2109375 8.55078125 10010 59.046875 61.5078125 57.7109375 48.7578125 21.875 21.2890625 34.51953125 10011 68.4453125 66.03125 59.1640625 54.3828125 25.296875 24.5703125 8.71484375 10012 52.015625 46.7890625 32.4453125 26.5625 17.7734375 19.53125 1.7421875 10015 68.6796875 69.359375 64.5078125 54.8984375 27.5 25.6953125 1.77734375 CN Arit CN + 75tPA Acrit CN + 150tPA Acrit CFF Acrit CFF + TXA Acrit CRT dAmax CN dAmax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) (mm) 10027 9.69921875 11.890625 7.44921875 1.49609375 1.53125 0.7734375 1.0078125 10036 10.75390625 2.7265625 3.67578125 1.61328125 1.56640625 1.078125 0.4921875 10013 8.515625 7.578125 6.21875 4.1328125 4.390625 1.1484375 0.5625 10099 6.6640625 2.0703125 0.2421875 0.6875 0.23046875 0.5390625 0.140625 10107 7.07421875 9.37109375 7.61328125 1.37890625 2.234375 0.796875 0.4453125 10093 10.0390625 9.04296875 8.515625 1.26171875 1.0859375 0.84375 0.84375 10044 6.16015625 2.80859375 1.54296875 0.359375 1.484375 0.421875 0.3046875 10068 13.0859375 6.58203125 8.66796875 0.3125 32.9140625 0.4921875 0.515625 10030 12.7578125 12.41796875 13.7890625 5.4453125 4.37890625 1.171875 1.40625 10077 8.0703125 5.50390625 6.18359375 1.015625 1.0390625 1.5703125 0.9375 10016 27.1953125 0.69921875 1.0390625 1.58984375 3.58203125 1.0078125 7.453125 10075 5.3515625 7.015625 6.60546875 3.8984375 3.23046875 1.7578125 1.03125 10090 9.83984375 9.3359375 6.51171875 1.15625 0.359375 0.5390625 0.4921875 10059 15.3359375 13.63671875 13.63671875 2.38671875 2.01171875 1.0078125 0.703125 10061 14.140625 11.84375 12.1015625 4.671875 5.1875 1.546875 1.078125 10097 9.4296875 7.77734375 8.140625 3.3828125 1.015625 0.9140625 0.9375 10025 10.26171875 12.81640625 9.58203125 4.4140625 3.41796875 1.734375 1.6640625 10050 9.98046875 9.8984375 8.76171875 2.3984375 2.515625 0.75 1.0546875 10060 5.66796875 14.796875 10.4609375 4.16796875 3.69921875 1.734375 0.3046875 10032 13.14453125 12.6640625 13.625 3.3828125 2.64453125 1.0546875 1.0546875 10106 4.84765625 5.234375 3.7578125 0.40625 0.4296875 0.5625 0.3984375 10063 9.46484375 7.7890625 8.48046875 2.41015625 2.22265625 1.0078125 1.1953125 10088 16.61328125 16.015625 14.8671875 39.0546875 3.34765625 0.8671875 0.6328125 10102 12.6875 12.18359375 8.62109375 26.78515625 0.37109375 0.515625 0.65625 10115 17.87890625 17.328125 16.8125 4.16796875 4.23828125 0.8671875 0.7734375 10014 10.37890625 9.7578125 13.47265625 3.4765625 3.9921875 0.9375 1.1953125 10085 13.16796875 12.27734375 13.4609375 4.07421875 4.40234375 1.6171875 1.4296875 10047 13.296875 13.19140625 13.6484375 5.421875 4.37890625 7.3828125 1.265625 10051 14.26953125 15.1484375 14.57421875 5.55078125 4.25 1.359375 1.4765625 10056 10.66015625 10.25 12.67578125 3.95703125 6.2890625 1.6875 1.4296875 10057 11.65625 10.91796875 11.52734375 4.44921875 5.7265625 1.875 1.921875 10039 12.875 9.6171875 10.28515625 1.6015625 2.99609375 1.2890625 1.03125 10067 12.3359375 11.5859375 12.62890625 43.54296875 3.5703125 0.75 0.75 10071 9.3125 0.125 9.265625 2.3046875 2.046875 0.7265625 0.515625 10104 11.73828125 9.81640625 10.91796875 5.421875 4.91796875 1.546875 1.3359375 10001 13.00390625 13.96484375 9.8046875 3.3828125 2.984375 1.4296875 0.6796875 10002 14.3984375 12.34765625 12.95703125 3.93359375 4.47265625 0.75 0.984375 10003 16.015625 15.16015625 14.0703125 6.3828125 6.1015625 1.40625 1.078125 10004 16.25 10.51953125 5.234375 2.9609375 1.16796875 0.703125 0.515625 10005 11.84375 11.83203125 11.15234375 2.41015625 1.625 1.03125 0.984375 10006 14.97265625 13.80078125 10.390625 4.42578125 4.859375 1.546875 0.9609375 10007 11.84375 8.94921875 12.65234375 14.17578125 4.390625 1.453125 1.171875 10008 14.10546875 18.55859375 15.34765625 8.9609375 6.8046875 1.3828125 0.6796875 10009 19.51953125 21.13671875 15.55859375 5.03515625 6.453125 1.5703125 1.1015625 10010 10.42578125 12.91015625 10.3671875 4.82421875 3.13671875 2.2734375 1.0546875 10011 13.05078125 13.40234375 13.70703125 5.31640625 5.22265625 1.4296875 0.8671875 10012 12.03125 9.58203125 11.15234375 2.0234375 1.96484375 0.9375 1.03125 10015 14.97265625 16.00390625 14.22265625 6.265625 5.36328125 1.2890625 1.0546875 CN + 75tPA dAmax CN + 150tPA dAmax CFF dAmax CFF + TXA dAmax Patient ID (mm) (mm) (mm) (mm) CRT LY30 CN LY30 10027 0.9375 0.8203125 0.8203125 0.28125 0.032181149 0.036531072 10036 0.1875 0.1640625 1.1015625 0.2578125 0.620687849 0.570174492 10013 0.515625 0.609375 0.5625 0.421875 0.122440453 0.17333015 10099 0.09375 0.046875 0.515625 0.1171875 0.700512063 0.676866667 10107 0.5859375 0.7265625 0.7265625 0.46875 0.206567617 0.301307892 10093 0.8203125 0.84375 0.3515625 0.234375 0.157658839 0.205500806 10044 0.3515625 0.0703125 0.1875 0.28125 0.795071377 0.8215557 10068 0.5859375 0.4921875 0.140625 0.140625 0.413549604 0.333138705 10030 1.4765625 1.3125 0.796875 0.8671875 0.049018013 0.048666115 10077 1.0546875 1.2421875 0.703125 0.65625 0.104187707 0.107589411 10016 1.1484375 1.828125 1.0546875 0.2109375 −3.82E−04 0.10379731 10075 1.078125 1.0546875 0.75 0.6328125 0.013590398 0.005073974 10090 0.46875 0.4921875 0.140625 0.234375 0.273513001 0.251932409 10059 0.7265625 0.6796875 0.2578125 0.2109375 0.403412504 0.205224691 10061 1.125 0.984375 0.796875 0.65625 0.01238212  0.016334176 10097 1.1953125 0.890625 1.03125 0.703125 0.013837838 0.020287418 10025 1.6171875 1.6640625 0.9375 0.9609375 0.020103147 0.020015858 10050 1.078125 1.0078125 0.515625 0.421875 0.017763607 0.016338611 10060 0.890625 0.984375 0.7734375 0.3046875 0.033260983 −0.087673758 10032 1.078125 1.078125 0.703125 0.5859375 0.079844138 0.07552534 10106 0.375 0.421875 0.140625 0.234375 0.037628265 0.009302761 10063 1.125 1.1953125 0.4453125 0.3515625 0.036809352 0.00174796 10088 0.65625 0.703125 0.5625 0.3515625 0.033335384 0.038860489 10102 0.5859375 0.5859375 0.1640625 0.2109375 0.013800905 0.004507344 10115 0.890625 0.65625 0.6796875 0.7265625 −9.07E−04 0.00166233 10014 1.40625 0.5859375 0.609375 0.609375 0.036194424 0.0174196 10085 1.4296875 1.265625 1.0546875 0.7265625 0.012515249 0.014965317 10047 1.4296875 1.171875 0.609375 0.7265625 0.015036548 0.023598091 10051 1.78125 0.9609375 0.8203125 0.609375 0.051359495 0.036818989 10056 1.3125 1.2890625 0.7265625 1.125 0.040883465 0.030727841 10057 1.8984375 1.8984375 0.9609375 1.078125 0.02123211  0.019522923 10039 1.265625 1.2421875 0.796875 0.7734375 0.030087314 0.021265554 10067 0.5625 0.8203125 39.2578125 0.5625 0.024026887 0.023099042 10071 0 0.515625 0.234375 0.1875 0.029964163 0.015405989 10104 1.7109375 1.6171875 0.984375 0.9140625 0.02263059  0.016736079 10001 0.7265625 0.65625 0.46875 0.515625 0.044339839 0.035448853 10002 1.1484375 1.0078125 0.5390625 0.4921875 0.020561684 0.01556089 10003 1.3359375 1.3125 0.984375 0.84375 0.023201246 0.02049543 10004 0.5390625 0.46875 0.75 0.5859375 0.673048416 0.667148241 10005 1.0546875 1.0078125 1.8515625 1.3125 0.06026761  0.049426 10006 1.1484375 1.21875 0.7734375 0.5625 0.034280048 0.006880259 10007 1.2890625 1.1953125 2.0859375 0.84375 0.014223939 0.015482503 10008 0.4453125 0.5390625 0.9375 0.609375 0.040747338 0.03000636 10009 1.0078125 0.8671875 0.7265625 0.75 0.026999381 0.014878642 10010 1.1015625 1.078125 0.8203125 1.5703125 0.034516958 0.035916 10011 0.8671875 1.1484375 0.5390625 0.4921875 0.023568783 0.021000454 10012 1.0078125 0.9140625 1.5 1.2890625 0.490499524 0.474602744 10015 1.0546875 0.9140625 0.5625 0.5859375 0.021365601 0.017188087 CN + 75tPA CN + 150tPA CFF + TXA CN + 75tPA CN + 150tPA Patient ID LY30 LY30 CFF LY30 LY30 CRT CL30 CN CL30 CL30 CL30 10027 0.610296293 0.877309947 0.001396878 −0.018850402 0.912123336 0.934834755 0.003984785 0.006469875 10036 0.883573059 0.90988339 0.723025145 −0.033342923 0.003840782 0.007555316 0.021917808 0.027303754 10013 0.764863695 0.920766765 0.18963098 −0.028770534 0.593161736 0.525195561 0.008221549 0.011242604 10099 0.862426372 0.803248588 0.741447884 −0.040334207 0.005529027 0.022545455 0.038554217 0.13559322 10107 0.721292673 0.869580028 0.486720653 −0.010193487 0.418545617 0.257952468 0.004039384 0.007588824 10093 0.659639012 0.875379913 0.443278128 −0.036288399 0.524144254 0.459086381 0.003660181 0.004752005 10044 0.874518786 0.844049815 0.814686964 −0.038434343 0.005782436 0.007073716 0.010549695 0.05904059 10068 0.684876616 0.863611367 0.646364594 −0.02922074 0.111365121 0.201390011 0.005203406 0.007383479 10030 0.5668166 0.87458624 0.190315235 −0.015613187 0.874441751 0.840135642 0.003636965 0.004418605 10077 0.630032517 0.814858822 0.300028085 0.030363322 0.632407545 0.656153196 0.002448355 0.003066309 10016 0.824400796 0.90074684 0.133519718 −0.037340764 0.95092875 0.708618331 0.008883953 0.019161677 10075 0.66195731 0.882000141 −0.01578034 −0.017857143 0.97717281 0.983767183 0.002786 0.004518498 10090 0.654669364 0.873151169 0.479155882 −0.01954441 0.329092735 0.370097619 0.00980873 0.006525285 10059 0.634131061 0.750124763 0.628603256 −0.01975195 0.048403708 0.434256785 0.003016023 0.004130098 10061 0.341356822 0.715671685 0.025839479 0.022295783 0.976489723 0.968080862 0.085127479 0.003677316 10097 0.295816654 0.749214506 −0.006116442 −0.006813975 0.967567568 0.959096543 0.217642698 0.003891997 10025 0.301405728 0.60935634 0.018522173 0.001226813 0.951041928 0.950255954 0.20271581 0.00240855 10050 0.239333478 0.692515011 −0.002336723 −0.001073493 0.960532086 0.967506199 0.334733488 0.003792368 10060 0.297550929 0.694521589 0.009783552 −0.057673629 0.937792388 1.141820024 0.236238532 0.003279361 10032 0.051217676 0.417378452 −0.010187088 −0.006750503 0.859234087 0.875775611 0.882370414 0.040428062 10106 0.455055955 0.935377457 0.003082386 −0.075740851 0.907649254 0.969820205 0.063463515 0.010037641 10063 0.006560459 0.550600117 −0.008719319 −0.015025572 0.932958199 0.987338719 0.974855171 0.00234192 10088 0.074793888 0.391418053 0.013625488 −0.012183384 0.926181102 0.90974212 0.789926763 0.08699734 10102 0.562845152 0.848988812 5.16E−04 0.005384027 0.972002262 0.984717269 0.002578566 0.005507745 10115 0.072674562 0.491382863 −0.014777091 −0.013430375 0.99515556 0.991030894 0.776780643 0.017445388 10014 0.016686346 0.239035744 −0.001005868 9.21E−04 0.930642339 0.961792623 0.966520376 0.34714781 10085 0.019434574 0.426500617 −0.00628196 0.00456849 0.971818958 0.965579303 0.957005804 0.040289118 10047 0.31609724 0.653241935 0.028920684 0.002780866 0.961126339 0.940027106 0.18950064 0.002949309 10051 0.129969698 0.588880654 0.003277692 0.00937838 0.900685741 0.916021848 0.617421109 0.013085259 10056 0.049351606 0.304203276 0.009619986 6.10E−04 0.918161152 0.934270222 0.842838196 0.175725987 10057 0.097372578 0.54744863 0.002834147 0.001678309 0.952088879 0.952893983 0.667924988 0.003013699 10039 0.065426612 0.356663192 −8.83E−04  0.001954369 0.937710034 0.951157111 0.806439582 0.131063238 10067 0.127341193 0.52226187 −0.089839901 −0.023327959 0.949104996 0.947476038 0.636821074 0.004378284 10071 1 0.823419372 0.074108123 0.010054454 0.913000424 0.946266189 1 0.009777083 10104 0.473321752 0.343410253 0.015296147 0.009525346 0.954550964 0.960018382 0.007070584 0.101463066 10001 0.125558464 0.574256955 0.003027092 0.014933231 0.905992303 0.920365169 0.639192221 0.003555389 10002 0.025736373 0.048507271 −0.026026803 −0.025764865 0.952032722 0.970827762 0.939868003 0.883221477 10003 0.285959784 0.639335257 3.64E−04 −0.006207827 0.950445173 0.953840814 0.20441989 0.003322259 10004 0.766353845 0.823688235 0.835254569 −0.004840428 0.004734528 0.005025126 0.005485087 0.007529412 10005 0.075513843 0.383931977 −0.028563488 −0.02444461 0.87859116 0.892052809 0.809435216 0.128636809 10006 0.121344584 0.527154661 0.009525573 0.010931438 0.93723235 0.979279166 0.615618795 0.003166436 10007 0.175179896 0.483857435 −0.017598157 −0.017704437 0.970870113 0.968898951 0.515861524 0.023453839 10008 0.186974559 0.347914843 −0.022982836 −0.014046307 0.914505176 0.936712117 0.529515844 0.214223195 10009 0.07481 0.452688 0.003454802 4.71E−04 0.941683958 0.963065661 0.794978088 0.02848 10010 0.153788562 0.578757411 −0.007364583 7.22E−04 0.926964806 0.919979677 0.568701773 0.005447845 10011 0.034518465 0.19155214 −0.013607937 −0.027164812 0.945896587 0.949952674 0.914828998 0.496624048 10012 0.691469018 0.849708333 0.680998168 −0.020095 0.024932412 0.07380197 0.003852637 0.004705882 10015 0.094819042 0.270578957 −0.007755682 −0.005489257 0.950176317 0.959788241 0.737313794 0.369005265 CFTX dV @ CFF max CN dV @ CN + tPA75 max CRT dA Integration to Acrit Patient ID CFF CL30 CFF + TXA CL30 (mm/min) (mm/min) (mm{circumflex over ( )}2) 10027 0.98767461 1.029193698 0 0.84375 4.167663574 10036 0.010680908 1.058688147 0.421875 3.65625 3.351928711 10013 0.428816467 1.064108155 0.28125 2.953125 0.851989746 10099 0.202978056 1.086500655 0.28125 1.6875 0.16973877 10107 0.054554311 1.022652194 0.421875 1.546875 0.385620117 10093 0.14637224 1.077275329 0.140625 1.265625 0.853637695 10044 0.027444254 1.084297521 0.28125 1.96875 0.402099609 10068 0.035827187 1.080028839 0.5625 1.96875 55.67266846 10030 0.444286728 1.030020013 0.140625 1.96875 0.866821289 10077 0.254694271 0.922886802 0.28125 0.84375 0.374084473 10016 0.601573346 1.072611465 0.28125 1.96875 11.56695557 10075 1.033469691 1.035615354 0 0.84375 45.57073975 10090 0.119930975 1.036753446 0.28125 1.40625 13.43243408 10059 0.028277635 1.035095321 0.28125 1.546875 1.507873535 10061 0.954743547 0.967379867 0.140625 0.140625 158.5063477 10097 1.013474888 1.011105969 0 0.28125 7.57232666 10025 0.963967056 0.998988196 0.140625 0.421875 24.0534668 10050 1.0023465 1.002477291 0 0.28125 71.05297852 10060 0.991847826 1.103661681 0.140625 0.84375 21.12670898 10032 1.016809862 1.014486922 0 0.5625 144.5267944 10106 0.928409091 1.132458234 0 0.5625 4.676879883 10063 1.00916186 1.022743682 0 0.140625 10.36724854 10088 0.984132981 1.036474164 0.140625 0.140625 108.4498901 10102 1.008746356 0.993648553 0 0.984375 60.84887695 10115 1.048890138 1.028829847 0.140625 0.28125 85.81365967 10014 1.015088013 0.996856444 0 0 13.54943848 10085 1.019265073 0.994602375 0 0.140625 18.49822998 10047 0.914398163 0.999047014 0.140625 0.5625 685.0376587 10051 0.999068323 0.985399091 0 0.28125 22.11547852 10056 0.978924863 1.000823497 0.140625 0.421875 44.68249512 10057 0.995422643 1.001770956 0 0.140625 50.58215332 10039 0.997866287 0.997877609 0 0.28125 27.48944092 10067 1.329345531 1.064493013 −0.140625 0.421875 130.4022217 10071 0.761251372 0.982497083 0.140625 1.125 3.468933105 10104 0.9706728 0.991066111 0.140625 0.703125 40.84606934 10001 0.990047917 0.969953775 0 0.28125 18.53118896 10002 1.070451843 1.076053757 0 0.421875 33.03479004 10003 0.998214817 1.026160075 0.140625 0.84375 88.00708008 10004 0.008355091 1.048026806 0.84375 3.65625 0.405395508 10005 1.04513199 1.037488843 0.140625 0.28125 10.16784668 10006 0.981231478 0.983039574 0.140625 0.28125 22.12866211 10007 1.029501748 1.04021197 0.421875 0.421875 25.69812012 10008 1.054860443 1.038157151 0 0.421875 79.16253662 10009 0.995246897 1.005616475 0.140625 0.28125 126.6432495 10010 1.0225 1.008807339 0 0.421875 342.4257202 10011 1.03428042 1.072496025 0 0.140625 120.1107788 10012 0.007032967 1.0348 0.5625 2.671875 1.974243164 10015 1.025568182 1.020979021 0 0.140625 16.7744751 CN dA Integration to Acrit CN + 75tPA dA Integration to Acrit CN + 150tPA dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10027 85.9520874 101.4642334 45.04669189 10036 35.29083252 3.318969727 5.532165527 10013 30.48376465 26.18261719 28.65124512 10099 7.577270508 1.272216797 0.019775391 10107 19.28265381 41.2300415 48.57000732 10093 56.30053711 62.28094482 61.1685791 10044 18.49493408 7.592102051 0.552062988 10068 57.52990723 26.35565186 37.64080811 10030 124.614624 154.8099976 178.7167969 10077 54.78771973 52.32073975 70.82391357 10016 47.28295898 0.248840332 0.771240234 10075 46.79187012 69.48083496 39.81280518 10090 25.65362549 35.08813477 22.11383057 10059 84.42773438 79.0010376 80.16778564 10061 129.7397461 115.2773438 100.2183838 10097 77.203125 74.16265869 68.04382324 10025 150.218811 161.7544556 138.9138794 10050 81.03790283 91.74462891 71.90496826 10060 14.2399292 119.973999 86.43164063 10032 95.99468994 120.9364014 131.7700195 10106 18.36639404 10.99182129 13.90209961 10063 70.71185303 78.4588623 91.31121826 10088 94.48846436 91.61279297 64.3458252 10102 56.65649414 65.57684326 44.1897583 10115 121.9993286 85.35388184 97.12023926 10014 111.3931274 118.4084473 66.15362549 10085 173.6295776 155.6900024 159.0864258 10047 147.9067383 162.7630005 143.6055908 10051 186.1671753 231.9521484 107.1282349 10056 126.6663208 54.03625488 143.7094116 10057 200.618042 164.661438 188.5501099 10039 123.7412109 88.77832031 101.6867065 10067 79.40478516 48.34094238 90.79046631 10071 37.39196777 0 39.15856934 10104 138.3964233 144.7278442 159.5033569 10001 75.84356689 60.63299561 53.13317871 10002 134.4034424 122.3388062 120.6018677 10003 157.7351074 175.6664429 143.7802734 10004 75.09375 51.08477783 17.79125977 10005 105.791748 104.5079956 97.47784424 10006 92.40875244 124.972229 106.2235107 10007 125.6231689 73.32220459 135.4202271 10008 75.42169189 47.03411865 63.8102417 10009 176.0454712 181.0288696 114.6494751 10010 90.99481201 116.6401978 93.13879395 10011 102.0822144 104.9727173 72.57733154 10012 84.82324219 82.31671143 86.3838501 10015 146.3724976 146.1582642 81.92449951 CFF dA CFF + TXA dA Integration to Acrit Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) ID SBP HR OR? ICU? Death? pRBC FFP PLT 10027 10.11346436 4.268188477 10027 150 Unk Yes Yes Yes 61 12 2 10036 5.04107666 3.314025879 10036 0 0 Yes Yes No 32 8 3 10013 2.231323242 16.37072754 10013 96 100 Yes Yes Yes 29 16 5 10099 0.260375977 0.087341309 10099 80 120 Yes Yes Yes 27 12 4 10107 0.393859863 9.271362305 10107 0 130 Yes Yes Yes 24 13 2 10093 0.271911621 0.557006836 10093 70 140 Yes Yes No 23 12 2 10044 0.052734375 3.348632813 10044 140 93 Yes Yes No 21 12 1 10068 0.046142578 18.60534668 10068 160 70 No Yes Yes 14 12 2 10030 18.28894043 30.75897217 10030 180 40 Yes Yes Yes 12 8 2 10077 0.283447266 5.164672852 10077 0 110 Yes Yes No 11 4 1 10016 14.26629639 7.041687012 10016 0 130 Yes 0 Yes 6 2 0 10075 29.9630127 18.2477417 10075 100 100 Yes Yes No 9 4 2 10090 0.177978516 0.411987305 10090 Unk Unk Yes Yes No 9 4 2 10059 2.480163574 3.093200684 10059 180 150 Yes Yes Yes 8 6 1 10061 35.8560791 32.24707031 10061 108 112 Yes Yes No 7 6 2 10097 30.8001709 5.164672852 10097 104 130 Yes Yes No 7 4 1 10025 38.51916504 28.14532471 10025 204 102 Yes Yes Yes 6 4 1 10050 11.390625 10.31945801 10050 107 89 Yes Yes No 6 4 1 10060 25.09991455 8.211730957 10060 70 112 Yes Yes No 6 3 0 10032 20.671875 13.52142334 10032 0 0 Yes Yes No 5 6 1 10106 0.385620117 0.639404297 10106 0 122 Yes Yes No 5 3 0 10063 10.2288208 6.98236084 10063 80 100 Yes Yes No 4 2 1 10088 49.21435547 11.0725708 10088 102 110 Yes Yes No 4 4 1 10102 19.89239502 0.430114746 10102 122 90 Yes Yes Yes 4 5 2 10115 19.7210083 26.19085693 10115 102 130 Yes Yes <28 d 4 4 2 10014 15.51049805 20.10827637 10014 80 110 Yes Yes No 3 1 0 10085 35.84454346 24.3583374 10085 132 108 Yes Yes No 3 0 0 10047 25.88598633 27.24554443 10047 0 120 Yes Yes No 2 1 0 10051 40.11602783 22.52087402 10051 110 124 Yes Yes No 2 0 0 10056 25.6206665 60.17321777 10056 108 100 Yes Yes No 2 0 0 10057 38.38238525 52.54980469 10057 90 130 Yes Yes No 2 2 0 10039 10.98852539 21.26019287 10039 140 120 Yes Yes No 1 0 0 10067 103.7993774 16.0378418 10067 100 120 Yes Yes No 1 0 0 10071 4.624145508 2.059936523 10071 90 80 Yes Yes No 1 2 0 10104 47.8861084 30.43267822 10104 100 72 Yes Yes No 1 0 0 10001 13.2989502 13.25280762 10001 132 90 No 0 No 0 0 0 10002 17.91815186 20.62738037 10002 110 110 Yes 0 No 0 0 0 10003 55.2557373 47.34228516 10003 118 120 Yes Yes No 0 0 0 10004 7.280639648 5.517858887 10004 0 0 No Yes No 0 0 0 10005 35.14910889 15.49072266 10005 124 120 Yes 0 No 0 0 0 10006 32.91778564 21.35083008 10006 60 86 No 0 No 0 0 0 10007 273.8776245 30.1673584 10007 98 66 Yes Yes No 0 2 0 10008 73.72595215 37.30297852 10008 84 90 Yes 0 No 0 0 0 10009 28.65618896 37.08874512 10009 72 112 Yes Yes No 0 0 0 10010 35.91375732 45.75531006 10010 Walk-in Walk-in No 0 No 0 0 0 10011 25.35040283 20.23187256 10011 124 72 Yes 0 No 0 0 0 10012 19.26452637 20.21868896 10012 0 0 No Yes Yes 0 0 0 10015 29.44885254 28.83416748 10015 122 112 Yes Yes No 0 0 0 Patient ID CRYO CN Crit Prod 10027 6 9.774993896 10036 4 5.292938232 10013 0 4.790039063 10099 6 0.937133789 10107 2 3.150238037 10093 2 8.470458984 10044 1 1.876922607 10068 1 6.747436523 10030 1 17.94067383 10077 0 7.565917969 10016 0 202.6900635 Artefact- Spike at end 10075 0 5.518798828 10090 2 4.843048096 10059 2 10.78308105 10061 0 15.24536133 10097 0 8.840332031 10025 1 17.07614136 10050 0 10.52627563 10060 0 1.726959229 10032 0 13.8633728 10106 0 1.931488037 10063 0 11.31344604 10088 0 10.51309204 10102 2 8.326171875 10115 0 13.82821655 10014 0 12.40603638 10085 0 18.82608032 10047 0 16.82885742 10051 0 21.06985474 10056 0 15.24069214 10057 0 22.40185547 10039 0 13.27734375 10067 0 9.251953125 10071 1 4.801757813 10104 0 15.68161011 10001 0 8.838592529 10002 0 14.17346191 10003 0 17.2668457 10004 0 8.37890625 10005 0 11.65869141 10006 0 14.38778687 10007 0 13.87939453 10008 0 9.587310791 10009 0 21.50198364 10010 0 10.99594116 10011 0 11.31747437 10012 0 12.40722656 10015 0 15.79147339 CRT Amax CN Amax CN + 75tPA Amax CN + 150tPA Amax CFF Amax CFF + TXA Amax CRT Acrit Patient ID (mm) (mm) (mm) (mm) (mm) (mm) (mm) 10017 59.5625 62.84375 58.6953125 45.59375 21.171875 19.71875 1.96484375 10019 67.765625 68.9609375 62 52.015625 27.8046875 25.765625 2.36328125 10020 68.9609375 66.2890625 62.890625 51.828125 23.8671875 23.328125 2.2109375 10021 10.6953125 15.546875 15.3125 11.6796875 16.6484375 9.5703125 0.62890625 10022 59.890625 64.4140625 59.84375 61.0859375 22.296875 19.7421875 1.1796875 10023 63.1015625 68.4453125 55.6015625 35.3046875 32.234375 32.5390625 11.01171875 10024 62.46875 66.8984375 57.8515625 38.6796875 22.203125 20.46875 1.1796875 10026 51.6875 50.515625 52.7421875 25.5859375 13.90625 13.7890525 11.41015625 10028 64.0390625 69.59375 66.6171875 57.8984375 27.640625 26.84375 1.484375 10029 65.6796875 65.140625 47.84375 29.421875 25.1328125 26.375 7.09765625 10031 61.8359375 61.1796875 49.0625 33.6640625 23.8203125 24.0078125 14 10033 62.0234375 66.59375 57.9453125 42.1484375 24.5234375 24.2421875 1.75390625 10034 60.640625 57.6875 43.0625 31.1796875 20.609375 17.8203125 14.33984375 10035 56.65625 60.5 52.6015625 47.0234375 20.046875 19.671875 1.89453125 10037 66.40625 70.53125 66.875 62.46875 25.25 24.6640625 1.859375 10038 60.8046875 58.625 51.7578125 51.0546875 23.0234375 24.8046875 4.28515625 10040 65.5859375 61.2265625 49.296875 46.6484375 25.8125 23.65625 6.55859375 10041 59.140625 63.546875 55.203125 35.3515625 21.1953125 21.0546875 1.14453125 10042 62.75 63.78125 56.5859375 44.28125 22.9296875 21.4765625 2.1875 10043 62.8671875 64.015625 54.6640625 36.640625 19.765625 19.6953125 4.77734375 10045 62.65625 63.171875 48.171875 25.6484375 27.9921875 23.703125 12.1015625 10046 49.6953125 55.7890625 51.40625 31.578125 19.15625 17.65625 0.8984375 10048 74.703125 73.8828125 65.890625 56.1171875 31.6953125 34.484375 7.84765625 10049 58.7421875 62.609375 55.4140625 49.859375 19.6484375 17.984375 14.66796875 10052 71.796875 70.2734375 67.0390625 35.234375 31.34375 29.3984375 7.578125 10053 65.5625 66.359375 62.0703125 57.6171875 24.2421875 23.5859375 1.6953125 10054 59.4453125 59.9375 50.4921875 41.65625 21.4765625 21.1484375 12.96875 10055 66.40625 66.21875 48.2890625 50.7734375 28.671875 26.84375 6.16015625 10058 57.8984375 58.7890625 50.84375 32.609375 21.6171875 20.84375 2.09375 10062 62.5859375 64.7421875 63.40625 58.9765625 25.4375 24.4765625 1.28515625 10064 72.78125 71.8671875 72.6640625 66.1953125 36.40625 34.9296875 5.73828125 10065 57.0546875 58.25 49.203125 35.3984375 21.2421875 22.15625 4.15625 10069 65.5625 69.9921875 70.8125 69.9453125 28.8125 28.4375 2.7265625 10070 48.546875 58.34375 52.9296875 46.1328125 17.2578125 15.6875 1.56640625 10072 67.9765625 64.25 63.8515625 54.921875 21.078125 22.203125 13.26171875 10073 72.078125 73.8828125 71.984375 28.5078125 31.9296875 93.78125 7.0859375 10074 64.7890625 67.7890625 62.328125 51.265625 20.140625 20.515625 1.58984375 10076 63.8984375 66.125 59.84375 49.765625 23.09375 23.375 2.66796875 10078 68.2578125 65.4921875 61.2734375 52.3203125 27.734375 26.28125 7.765625 10079 70.1328125 71.6328125 67.8828125 41.4921875 40.0390625 31.0625 2.48046875 10080 56.0234375 55.859375 56.75 36.8515625 18.2421875 16.4609375 11.69140625 10081 69.3359375 68.46875 67.296875 62.984375 27.4765625 25.4375 17.10546875 10082 53.703125 51.40625 54.9921875 53.3515625 20.1171875 18.8515625 2.1171875 10083 58.6015625 62.328125 61.6484375 55.15625 25.15625 22.390625 2.43359375 10084 63.640625 65.2578125 63.4765625 57.4765625 27.265625 26.1875 6.23046875 10086 65.65625 64.6953125 62.75 46.3671875 26.234375 24.5703125 17.796875 10087 70.34375 66.59375 66.6875 59.046875 31.625 33.9453125 14.03515625 10089 63.40625 72.1953125 68.2578125 60.0078125 27.171875 28.4609375 3.2421875 CN Arit CN + 75tPA Acrit CN + 150tPA Acrit CFF Acrit CFF + TXA Acrit CRT dAmax CN dAmax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) (mm) 10017 13.77734375 15.2421875 13.02734375 3.78125 3.65234375 1.3359375 0.7734375 10019 16.12109375 13.66015625 9.0078125 1.484375 4.4140625 1.6640625 1.1953125 10020 16.37890625 14.1171875 13.44921875 4.80078125 5.31640625 1.359375 0.8671875 10021 2.41015625 3.6171875 2.1640625 2.984375 1.2734375 0.5390625 0.5390625 10022 11.046875 10.49609375 12.39453125 1.3203125 1.1796875 0.984375 0.9375 10023 16.51953125 13.0625 13.0625 4.4140625 6.58203125 1.5234375 1.1953125 10024 6.78125 18.69921875 10.484375 3.921875 3.265625 0.9375 1.171875 10026 10.56640625 8.7734375 7.89453125 0.32421875 1.671875 0.7265625 0.8203125 10028 14.65625 15.8046875 14 3.4765625 3.67578125 1.40625 1.40625 10029 16.47265625 10.625 13.8125 4.14453125 4.21484375 1.2421875 0.7265625 10031 12.46484375 12.65234375 11.84375 2.10546875 3.875 1.21875 1.1015625 10033 13.87109375 15.93359375 13.21484375 5.84375 5.09375 1.1015625 0.8671875 10034 12.69921875 13.84765625 9.16015625 0.8515625 2.609375 0.8203125 0.8203125 10035 10.390625 8.46875 7.84765625 4.35546875 2.85546875 1.3828125 1.03125 10037 14.46875 15.5234375 13.015625 4.19140625 4.58984375 1.546875 1.5 10038 12.265625 16.4375 14.4921875 3.79296875 5.69140625 1.1484375 0.65625 10040 11.59765625 10.98828125 17.03515625 6.37109375 5.75 1.1484375 0.6796875 10041 14.046875 8.1640625 9.98046875 3.25390625 3.21875 0.8671875 0.9375 10042 14.234375 14.69140625 10.3203125 4.16796875 3.3125 1.125 1.03125 10043 13.30859375 15.3359375 12.44140625 5.31640625 4.56640625 0.9609375 1.0546875 10045 13.2734375 12.0546875 9.40625 7.109375 5.7265625 0.984375 1.03125 10046 7.77734375 6.67578125 7.671875 2.3046875 1.90625 0.796875 1.1015625 10048 14.984375 21.37109375 14.97265625 8.57421875 8.64453125 1.9453125 1.640625 10049 11.4453125 11.328125 11.71484375 3.83984375 2.9140625 0.8671875 0.9375 10052 15.1953125 18.3359375 11.69140625 6.21875 4.49609375 1.359375 1.21875 10053 15.39453125 13.05078125 11.1171875 4.1328125 4.82421875 1.6875 1.1015625 10054 12.11328125 12.0078125 14.3515625 3.9453125 3.6875 0.890625 0.7734375 10055 13.28515625 9.04296875 12.76953125 7.54296875 6.734375 1.3359375 1.0546875 10058 11.69140625 9.5234375 11.1171875 4.42578125 3.04296875 1.734375 1.0546875 10062 14.4921875 12.30078125 12.0546875 4.109375 4.90625 1.1953125 0.796875 10064 12.9921875 14.45703125 14.80859375 5.73828125 5.421875 1.5234375 1.359375 10065 12.453125 6.51171875 9.1015625 4.12109375 5.48046875 1.03125 0.75 10069 15.76953125 14.50390625 14.8203125 5.90234375 6.18359375 2.296875 1.4296875 10070 9.8984375 8.99609375 10.77734375 2.45703125 15.96875 0.8203125 0.984375 10072 15.55859375 15.125 14.87890625 5.140625 3.60546875 1.3359375 0.9140625 10073 15.37109375 16.859375 20.57421875 7.5078125 46.75390625 4.03125 1.8984375 10074 11.1875 8.94921875 9.0078125 3.13671875 2.90234375 1.1015625 1.21875 10076 14.3515625 17.6328125 13.75390625 4.49609375 4.484375 2.0390625 1.171875 10078 19.21484375 14.7734375 15.2421875 6.078125 6.40625 1.875 1.1484375 10079 10.98828125 12.11328125 14.2109375 11.046875 5.22265625 2.2265625 1.9921875 10080 12.58203125 10.58984375 12.32421875 4.15625 19.30859375 0.8671875 0.4921875 10081 15.95703125 15.828125 18.55859375 7.4140625 5.24609375 1.4765625 1.0546875 10082 15.2890625 14.85546875 13.8359375 4.87109375 3.875 1.734375 0.515625 10083 10.89453125 10.6953125 10.33203125 4.15625 3.46484375 1.7109375 1.0546875 10084 14.65625 12.546875 12.20703125 4.8125 4.70703125 1.8046875 1.265625 10086 17.703125 17.234375 14.2578125 5.796875 4.28515625 0.84375 0.703125 10087 19.0625 26.41015625 19.47265625 7.23828125 7.40234375 1.2890625 0.796875 10089 12.5703125 11.64453125 10.6484375 5.03515625 8.2578125 1.96875 2.15625 CN + 75tPA dAmax CN + 150tPA dAmax CFF dAmax CFF + TXA dAmax Patient ID (mm) (mm) (mm) (mm) CRT LY30 CN LY30 10017 0.890625 0.8671875 0.375 0.2578125 0.06030463 0.016644911 10019 1.1953125 1.125 1.5 0.703125 0.018560257 0.022788509 10020 0.890625 0.8203125 0.5390625 0.5390625 0.030007206 0.014039481 10021 0.703125 0.375 2.484375 1.03125 −0.069673728 −0.032943886 10022 0.8203125 1.0546875 0.9375 0.796875 0.015688864 0.01108298 10023 0.9375 0.46875 1.03125 1.1953125 0.050798564 0.02016465 10024 0.9140625 1.078125 0.515625 0.421875 0.051351544 0.03619448 10026 0.9375 0.8203125 0.1640625 0.140625 0.0408322 0.045881663 10028 1.40625 1.40625 0.84375 0.8671875 0.036332229 0.01844581 10029 0.609375 0.421875 0.8671875 0.8671875 0.04213007 0.013138143 10031 1.0078125 0.890625 1.1953125 0.46875 0.075543799 0.097434874 10033 0.8671875 0.8203125 0.796875 0.75 0.026377517 0.018340861 10034 0.6328125 0.6796875 0.5625 0.375 0.033425663 0.02512734 10035 0.9375 1.0546875 0.8203125 0.6328125 0.020279463 0.02175914 10037 1.5 1.5 0.8671875 0.7734375 0.030046405 0.021488548 10038 0.515625 0.609375 0.9140625 1.0546875 0.026372114 −0.001829025 10040 0.4453125 0.6796875 0.9609375 0.890625 0.04965042 0.028593531 10041 1.03125 0.8203125 0.6328125 0.5625 0.041559335 0.021645254 10042 1.1953125 1.265625 0.8671875 0.703125 0.028059636 0.027165333 10043 0.984375 1.0078125 0.5859375 0.6796875 0.019282548 0.021101822 10045 0.75 0.703125 1.171875 0.75 0.010444722 0.012927694 10046 1.1484375 1.125 0.421875 0.328125 0.020347299 0.019610932 10048 1.1015625 1.2421875 0.9609375 1.1484375 0.020143973 0.015210808 10049 0.9375 0.8671875 0.5390625 0.375 0.040608237 0.031604588 10052 1.3125 0.7265625 0.796875 0.5859375 0.017503627 0.013801031 10053 1.1953125 1.125 0.65625 0.6796875 0.011311864 0.015675281 10054 0.703125 0.75 0.421875 0.421875 0.054953929 0.027473823 10055 1.0546875 1.1953125 1.1484375 0.9375 0.015969118 0.017118432 10058 1.125 1.03125 0.6796875 0.4921875 0.029763752 0.026953488 10062 0.8671875 0.890625 0.703125 0.65625 0.021739726 0.016778287 10064 1.5234375 1.4765625 1.1015625 1.078125 0.026595224 0.023099733 10065 0.9609375 1.03125 0.9140625 0.8203125 0.018600233 0.025373115 10069 1.6171875 1.453125 0.9140625 0.8671875 0.013138008 0.011164596 10070 0.9609375 1.0078125 0.4453125 1.078125 0.022669018 0.016251562 10072 1.171875 1.1015625 0.46875 0.4921875 0.026998812 0.019600661 10073 2.203125 5.0859375 1.171875 3.1640625 0.032281957 0.033183973 10074 1.5703125 1.3125 0.5859375 0.5390625 0.024875899 0.031321629 10076 1.078125 0.9609375 0.6796875 0.609375 0.045710899 0.028091361 10078 1.171875 1.078125 1.171875 0.984375 0.03587902 0.036731083 10079 2.1796875 2.296875 2.953125 1.2421875 0.012896383 0.004602465 10080 0.8203125 0.7734375 0.515625 3.1171875 0.028764003 0.019558275 10081 1.171875 1.0078125 0.9375 0.5859375 0.03960892 0.020360281 10082 0.6796875 0.5625 0.4453125 0.46875 0.03400434 0.026273852 10083 1.40625 1.5703125 1.03125 0.6328125 0.02385182 0.019988301 10084 1.3125 1.3828125 0.9375 0.9140625 0.009423337 0.021685821 10086 0.75 0.609375 0.75 0.5859375 0.036625251 0.023212273 10087 0.9609375 0.6328125 0.5390625 0.8671875 0.024173361 0.017043544 10089 2.2265625 1.453125 1.1015625 2.15625 0.020497577 0.025572178 CN + 75tPA CN + 150tPA CFF + TXA CN + 75tPA CN + 150tPA Patient ID LY30 LY30 CFF LY30 LY30 CRT CL30 CN CL30 CL30 CL30 10017 0.081614091 0.569954211 −0.001500615 −0.048368991 0.883525708 0.958975634 0.768401438 0.002741604 10019 0.100859305 0.454886769 0.003487637 −0.009435011 0.957804934 0.950039651 0.691532258 0.013667768 10020 0.060452899 0.432118003 −0.003161484 −0.006205347 0.947320721 0.965350619 0.849068323 0.102351522 10021 −0.032157738 0.127611483 −0.006157125 −0.030527211 1.118334551 1.051256281 1.075 0.672909699 10022 0.011277198 0.026278403 0.04736335 0.043820077 0.962822854 0.970527592 0.967101828 0.933623225 10023 0.106925905 0.536037656 0.001784416 0.006433573 0.900829516 0.94966328 0.72179289 0.028103563 10024 0.432249981 0.633892143 0.02721235 0.135655746 0.900575288 0.918019386 0.019986496 0.003837609 10026 0.128821656 0.681686502 −0.007343165 −0.002573182 0.912031439 0.903495206 0.658717227 0.004701734 10028 0.070189301 0.48095455 −0.011132702 −0.006824796 0.936318165 0.970026942 0.773777413 0.004587775 10029 0.265292973 0.589190565 0.0284828 −0.018540186 0.911145474 0.962221156 0.398922273 0.00424854 10031 0.609129512 0.6387822 0.367293922 −0.005472394 0.79949463 0.741412336 0.002547771 0.003713159 10033 0.095054717 0.423588199 −4.86E−04  −0.002458642 0.949741781 0.956710465 0.732236753 0.125857275 10034 0.18634948 0.60229057 0.013688821 0.013426129 0.931203298 0.947183099 0.460087083 0.007767477 10035 0.0364523 0.300278285 −0.013139777 −0.010031109 0.953667954 0.953899793 0.904203178 0.145705267 10037 0.062978323 0.313275214 0.001045534 0.001356773 0.942470588 0.956468764 0.834579439 0.129564782 10038 0.002257233 0.024505653 −0.004964088 −0.005459318 0.934087113 0.988006397 0.985962264 0.952716144 10040 0.079753038 0.362801457 −0.003030418 −0.015363551 0.906372841 0.931478882 0.806022187 0.176519846 10041 0.072059274 0.468926949 0.01875384 0.003831169 0.914002642 0.943570199 0.799179168 0.114254144 10042 0.159310139 0.555088509 6.02E−04 0.007616406 0.939492032 0.943042626 0.521192876 0.002822865 10043 0.340209296 0.615954158 −0.004230896 −0.006153312 0.954517211 0.947644618 0.184936401 0.004690832 10045 0.233396854 0.717038532 −0.026521072 −0.031434025 0.975311721 0.969577047 0.378203049 0.004873591 10046 0.229340172 0.645899307 −0.015154296 −0.010567847 0.953309228 0.952947766 0.37218845 0.003958436 10048 0.060154171 0.495028192 0.013921412 0.010570533 0.950428781 0.969546368 0.82712829 0.027286649 10049 0.075264933 0.473617858 7.89E−04 0.004389299 0.911823381 0.92887447 0.805864937 0.016139141 10052 0.157126695 0.32081578 −0.006094217 −0.007797413 0.956909684 0.972984992 0.563337606 0.26097561 10053 0.046222991 0.305119209 −0.011028306 −0.012549685 0.972473785 0.96362138 0.874260541 0.198237288 10054 0.167679483 0.604487059 0.017146639 0.007753048 0.889998686 0.934306569 0.543710351 0.00300075 10055 0.101571797 0.302263169 −0.002832652 −0.012365396 0.960823529 0.956111373 0.729655396 0.224957686 10058 0.492045474 0.728459911 0.010215637 0.009807596 0.934421805 0.93461794 0.015826675 0.003833253 10062 0.018351097 0.420841429 5.95E−04 −0.006456804 0.955436275 0.960178593 0.957121735 0.065704067 10064 0.078911616 0.501083179 5.00E−04 0.003245918 0.945577501 0.952060007 0.756800344 0.004366812 10065 0.662967521 0.860495292 −0.003749847 −0.016334626 0.956045461 0.947290773 0.002540489 0.003531229 10069 0.068198674 0.405900722 −0.021435512 −0.05345696 0.968898951 0.978569037 0.781553398 0.068803753 10070 0.166666052 0.620378916 0.027281701 0.026450448 0.955101384 0.963042314 0.493874539 0.003725656 10072 0.100680595 0.428920697 −0.005763529 0.001426519 0.937938168 0.952942607 0.690566499 0.006970128 10073 0.030185044 0.277177537 0.0096862 0.963302857 0.928463039 0.927038173 0.920555676 0.259249109 10074 0.480037116 0.733005689 0.043781786 0.007443196 0.937417099 0.921170912 0.017798947 0.002438281 10076 0.164391319 0.455341226 0.015017479 0.009141971 0.910869299 0.940808129 0.53002611 0.096232339 10078 0.051553756 0.569544199 0.005193271 0.007651688 0.927206135 0.920553501 0.851969909 0.002389129 10079 0.445629052 0.813086048 −0.057418699 −0.009947183 0.970925699 0.996073727 0.007710899 0.035209942 10080 0.224187202 0.704488199 0.030031525 −0.024219533 0.934737136 0.95048951 0.304102423 0.003391986 10081 0.024098689 0.183163642 0.006851246 0.018016738 0.918197183 0.949680511 0.948804272 0.434383528 10082 0.028358471 0.054769895 −0.160043689 −0.015227126 0.924934536 0.945744681 0.941184827 0.858544443 10083 0.277498451 0.702136449 0.020317892 0.010942952 0.945607252 0.953371772 0.251805855 0.002266289 10084 0.224975897 0.606549884 0.018206383 0.00716612 0.970905966 0.946845445 0.3472 0.0021748 10086 0.025188655 0.276866049 −0.109540649 −0.524623741 0.932175155 0.947470112 0.945094622 0.358550969 10087 0.044756847 0.265357348 −0.111567441 −0.048439778 0.95302088 0.964453308 0.880506092 0.307356444 10089 0.048802507 0.569068155 −0.004630295 0.004302772 0.950468211 0.941240126 0.836213803 0.002083062 CFTX dV @ CFF max CN dV @ CN + tPA75 max CRT dA Integration to Acrit Patient ID CFF CL30 CFF + TXA CL30 (mm/min) (mm/min) (mm{circumflex over ( )}2) 10017 1 1.199683043 0 0.28125 21.30633545 10019 0.983984265 1.018192844 0.28125 0.5625 31.7411499 10020 1.00589198 1.015070328 0 0.140625 24.37976074 10021 1.015485687 1.071020408 0.140625 −0.140625 1.959411621 10022 0.90119131 0.909774436 0.28125 0.140625 8.127685547 10023 0.993456132 0.987755102 0 0.140625 146.5043335 10024 0.933497537 0.966793893 0.28125 0.421875 7.781616211 10026 1.001685393 0.996600567 0 0.421875 83.27911377 10028 1.014414924 1.010477299 0 0.140625 14.05371094 10029 0.917003419 1.042654028 0.140625 0.84375 87.20123291 10031 0.128238767 1.015619915 0.421875 0.984375 161.4298096 10033 1 1.012568482 0.140625 0.421875 15.75604248 10034 0.977255497 0.978956598 0.140625 0.84375 88.0713501 10035 1.018706157 1.016679905 0.140625 0.421875 20.97674561 10037 0.993502475 0.994298385 0 0.28125 20.60925293 10038 1.007125891 1.011338583 0.140625 0 46.12445068 10040 1.006355932 1.052509908 0 0.28125 73.39471436 10041 0.950239587 0.99109462 0.140625 0.421875 6.969177246 10042 1 0.99454347 0 0.421875 22.359375 10043 1.008300395 1.020230067 −0.140625 0.5625 31.41156006 10045 1.060284678 1.070204351 −0.140625 0.5625 110.9465332 10046 1.024469821 1.015929204 0 0.28125 4.541748047 10048 0.96672418 0.980969642 0.140625 0.28125 105.1243286 10049 0.992842942 0.990877498 0 0.28125 130.3511353 10052 1.011964108 1.014350252 0 0.28125 80.39025879 10053 1.016435707 1.02285525 0 0.140625 19.06677246 10054 0.973808658 0.992242335 0.140625 0.421875 106.6256104 10055 1.004087193 1.023573923 0 0.28125 76.30169678 10058 0.976147452 0.982008996 0.140625 0.703125 27.76794434 10062 1.011977887 1.016278327 0 0.140625 10.21893311 10064 1.018669528 0.999329009 −6.00E−15 0.140625 78.70770264 10065 1.005516734 1.029619182 0 1.265625 41.66015625 10069 1.087039046 1.212637363 −0.140625 0.140625 47.99816895 10070 0.95382526 0.947709163 0.140625 0.421875 11.39886475 10072 1.015567087 1.001055595 −0.140625 0.28125 169.7272339 10073 0.983117201 0.001582806 2.109375 0 266.918335 10074 0.867339022 0.99428789 0.140625 0.703125 13.6137085 10076 0.967523681 0.987967914 0.28125 0.5625 42.14959717 10078 0.998309859 0.991973841 0.140625 0.28125 104.5129395 10079 1.164487805 1.018108652 0.140625 0.5625 40.72576904 10080 0.944753747 1.316089226 0.140625 0.984375 80.52703857 10081 0.981234006 0.962223587 0.140625 0.140625 273.0470581 10082 1.481165049 1.103191048 0 0.140625 28.32495117 10083 0.961801242 0.988485694 0.140625 0.28125 34.64154053 10084 0.976790831 0.99552506 0.140625 0.140625 100.7177124 10086 1.363609291 2.398410175 0.28125 0.140625 128.4246826 10087 1.343873518 1.18296893 −0.140625 0.28125 138.6172485 10089 1.024151811 0.996706012 0.140625 0.140625 53.89782715 CN dA Integration to Acrit CN + 75tPA dA Integration to Acrit CN + 150tPA dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10017 94.42584229 128.0390625 101.446106 10019 176.0718384 131.9265747 77.90844727 10020 108.4432983 107.7000732 88.54925537 10021 10.69354248 22.64941406 6.423706055 10022 89.33532715 71.53582764 119.2175903 10023 175.1193237 96.00292969 48.77600098 10024 66.48486328 171.0027466 99.48999023 10026 72.15545654 69.8104248 50.5178833 10028 177.543457 192.3255615 163.6281738 10029 108.4235229 49.97900391 52.5201416 10031 104.6365356 95.62884521 86.88647461 10033 107.480896 101.4098511 85.96856689 10034 91.47601318 77.46844482 49.8883667 10035 93.51123047 68.41296387 68.36846924 10037 194.5535889 209.1115723 169.8145752 10038 64.14477539 73.65673828 75.53210449 10040 60.17816162 37.54193115 100.8495483 10041 111.1772461 30.91552734 69.57476807 10042 139.6043701 149.2036743 113.6920166 10043 120.5161743 126.173584 105.0518188 10045 121.7636719 73.59741211 55.30517578 10046 76.05780029 48.24041748 76.40222168 10048 179.8571777 184.911438 147.2590942 10049 96.63244629 91.41833496 94.50164795 10052 158.8392334 190.2095947 46.33209229 10053 161.8994751 101.8580933 103.1022949 10054 81.1038208 66.59692383 82.92810059 10055 120.0481567 55.00360107 129.8139038 10058 110.1373901 89.20019531 79.67834473 10062 93.27392578 81.41363525 100.6468506 10064 116.4210205 205.6195679 207.8245239 10065 77.69421387 48.6260376 74.17749023 10069 197.9401245 188.4710083 182.1873779 10070 91.3392334 58.20062256 104.883728 10072 128.9833374 158.1075439 152.0348511 10073 257.6453247 311.8577979 98.69732666 10074 120.9594727 96.13311768 108.487793 10076 142.8343506 103.7120361 111.0997925 10078 177.0441284 124.2784424 139.541748 10079 186.0320435 230.6552124 201.6463623 10080 36.67181396 79.13616943 87.91644287 10081 143.079895 147.1552734 149.0718384 10082 68.89086914 87.04962158 64.06237793 10083 100.2694702 137.142334 149.5794067 10084 178.5157471 151.3707275 155.8811646 10086 100.1524658 110.9432373 68.44262695 10087 140.5206299 191.46698 111.8084106 10089 196.9431152 151.2372437 114.6115723 CFF dA CFF + TXA dA Integration to Acrit Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) ID SBP HR OR? ICU? Death? pRBC FFP PLT 10017 12.61669922 9.226867676 10017 80 116 Yes Yes No 0 0 0 10019 14.46240234 28.41064453 10019 86 90 Yes Yes No 0 0 0 10020 21.8897D947 22.59503174 10020 136 100 Yes 0 No 0 0 0 10021 57.74084473 9.508666992 10021 80 103 Yes 0 No 0 0 0 10022 8.803344727 6.862060547 10022 138 88 No Yes No 0 0 0 10023 45.24279785 76.33795166 10023 106 120 Yes 0 No 0 0 0 10024 17.62646484 8.737426758 10024 150 108 Yes Yes No 0 0 0 10026 0.278503418 1.496337891 10026 116 100 Yes Yes No 0 0 1 10028 24.4588623 26.37213135 10028 102 100 No Yes No 0 0 0 10029 30.09979248 31.25994873 10029 62 120 Yes Yes No 0 0 0 10031 1.105773926 15.78076172 10031 Uto Uto Yes Yes No 0 0 0 10033 42.42150879 34.27734375 10033 110 94 Yes Yes No 0 0 0 10034 3.371704102 7.218017578 10034 140 100 Yes Yes No 0 0 0 10035 34.21307373 14.93206787 10035 80 70 Yes Yes No 0 0 0 10037 34.14385986 33.68243408 10037 180 120 No Yes No 0 0 0 10038 30.17559814 40.28082275 10038 128 120 Yes Yes No 0 0 0 10040 53.66217041 27.57348633 10040 162 108 No 0 No 0 0 0 10041 18.02032471 15.65222168 10041 88 70 Yes Yes No 0 2 1 10042 24.84283447 19.11621094 10042 100 90 Yes Yes No 0 0 0 10043 29.10772705 26.66546631 10043 90 60 Yes Yes No 0 0 0 10045 70.72998047 37.99841309 10045 100 58 No Yes Yes 0 0 0 10046 7.864013672 5.115234375 10046 130 90 No 0 No 0 0 0 10048 56.56915283 80.21722412 10048 88 112 No 0 No 0 0 0 10049 16.1416626 9.149414062 10049 Walk-in Walk-in No 0 No 0 0 0 10052 34.28393555 21.70184326 10052 100 100 Yes Yes No 0 0 0 10053 20.61584473 28.09588623 10053 116 110 Yes Yes No 0 0 0 10054 15.07543945 13.2989502 10054 108 124 Yes Yes No 0 0 0 10055 59.88153076 55.71386719 10055 136 78 No Yes No 0 0 0 10058 26.85992432 11.59661865 10058 118 110 Yes Yes No 0 0 0 10062 23.73046875 25.08178711 10062 86 60 No 0 No 0 0 0 10064 56.35821533 51.12597656 10064 118 72 No 0 No 0 0 0 10065 31.25335693 38.93609619 10065 140 120 No Yes No 0 0 0 10069 48.08880615 39.92816162 10069 90 140 Yes Yes No 0 0 0 10070 8.679748535 20.0291748 10070 160 92 Yes 0 No 0 0 0 10072 17.0859375 14.16412354 10072 Unk Unk No 0 No 0 0 0 10073 62.96813965 963.953064 10073 156 114 Yes Yes No 0 0 0 10074 11.56365967 13.36651611 10074 81 100 Yes Yes No 0 0 0 10076 26.94232178 20.18408203 10076 170 60 Yes Yes No 0 0 1 10078 59.2701416 55.34472656 10078 96 60 Yes Yes No 0 0 0 10079 238.847168 49.64117432 10079 82 112 No Yes No 0 0 0 10080 15.51708984 96.45941162 10080 98 112 No 0 No 0 0 0 10081 61.43225098 24.95159912 10081 Walk-in Walk-in Yes Yes No 0 0 0 10082 18.13897705 11.51916504 10082 138 120 No 0 No 0 0 0 10083 38.19287109 19.47052002 10083 142 70 Yes Yes No 0 0 0 10084 42.3951416 29.05499268 10084 170 104 No Yes No 0 0 0 10086 35.31884766 18.47186279 10086 100 120 Yes 0 No 0 0 0 10087 32.47283936 53.8895874 10087 162 120 No 0 No 0 0 0 10089 50.00042725 125.1551514 10089 120 80 Yes Yes No 0 0 0 Patient ID CRYO CN Crit Prod 10017 0 10.65591431 10019 0 19.26974487 10020 0 14.20358276 10021 0 1.299224854 All tubes clotted 10022 0 10.35644531 10023 0 19.7460022 10024 0 7.946777344 10026 0 8.667755127 10028 0 20.61035156 10029 0 11.96841431 10031 0 13.73080444 10033 0 12.02883911 10034 0 10.41732788 10035 0 10.71533203 10037 0 21.703125 10038 0 8.049316406 10040 0 7.882781982 10041 0 13.16894531 10042 0 14.67919922 10043 0 14.03640747 10045 0 13.68823242 10046 0 8.567230225 10048 0 24.58374023 10049 0 10.72998047 10052 0 18.51928711 10053 0 16.95803833 10054 0 9.368865967 10055 0 14.01168823 10058 0 12.33078003 10062 0 11.54846191 10064 0 17.66125488 10065 0 9.33984375 10069 0 22.54550171 10070 0 9.743774414 10072 0 14.2215271 10073 0 29.18106079 10074 0 13.63476563 10076 0 16.8182373 10078 0 22.06704712 10079 0 21.89071655 10080 0 6.192718506 10081 0 16.8296814 10082 0 7.883422852 10083 0 11.49032593 10084 0 18.54931641 10086 0 12.44750977 10087 0 15.19042969 10089 0 27.10473633 CRT Amax CN Amax CN + 75tPA Amax CN + 150tPA Amax CFF Amax CFF + TXA Amax CRT Acrit Patient ID (mm) (mm) (mm) (mm) (mm) (mm) (mm) 10092 67.90625 69.7578125 68.9140625 61.765625 21.40625 21.2890625 17.76171875 10094 64.671875 65.0703125 63.03125 58.7421875 26.1640625 24.8046875 2.48046875 10096 63.640625 65.1875 64.7421875 65.1875 24.6171875 24.8984375 18.40625 10098 59.703125 66.171875 62.5625 61.625 19.296875 19.953125 1.84765625 10100 66.734375 71.65625 67.6015625 54.125 26.0703125 26.65625 2.29296875 10101 63.0546875 66.6640625 64.1328125 55.25 24.3359375 24.3359375 2.1640525 10103 66.4296875 68.46875 63.7109375 45.484375 28.390625 26.65625 10.51953125 10105 56.7734375 60.4296875 62.140625 52.203125 26.5625 24.5 1.84765625 10108 52.2265625 65.375 58.765625 59 20.2578125 18.734375 1.35546875 10109 62.8671875 66.3828125 63.546875 58.8359375 24.359375 24.0546875 2.66796875 10110 65.84375 64.15625 66.78125 65.5625 22.7890625 21.9921875 1.6953125 10111 67.6015625 73.5078125 71.1875 68.6796875 26.6328125 26.65625 15.5703125 10112 82.1328125 62.5625 60.03125 54.4765625 29.2578125 0.125 11.8203125 10113 50.3046875 48.125 28.6015625 23.5625 15.9921875 14.65625 11.375 CN Arit CN + 75tPA Acrit CN + 150tPA Acrit CFF Acrit CFF + TXA Acrit CRT dAmax CN dAmax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) (mm) 10092 16.859375 16.70703125 14.65625 3.76953125 3.72265625 0.9609375 0.9375 10094 12.828125 14.29296875 15.53515625 6.25390625 6.21875 2.2734375 1.125 10096 16.15625 13.9765625 13.75390625 3.67578125 4.71875 0.984375 1.03125 10098 6.41796875 7.09765625 8.19921875 1.56640625 2.19921875 1.1953125 1.4296875 10100 13.15625 16.82421875 16.765625 4.390625 5.7734375 1.7578125 1.265625 10101 10.1796875 10.4609375 8.78515625 4.109375 3.91015625 1.40625 1.453125 10103 11.26953125 9.9453125 8.38671875 4.4375 27.875 1.3828125 1.4296875 10105 14.328125 15.18359375 12.8515625 5.609375 4.96484375 1.6640625 0.9375 10108 9.640625 10.15625 8.3515625 1.390625 2.0703125 0.9140625 1.3125 10109 14.10546875 9.7578125 10.49609375 2.92578125 3.72265625 1.8515625 1.1953125 10110 11.41015625 9.41796875 10.2734375 3.546875 3.359375 1.828125 1.0546875 10111 13.90625 11.8203125 14.84375 4.578125 4.89453125 1.78125 1.734375 10112 19.7890625 17.75 16.6953125 5.65625 0.16015625 3.84375 0.75 10113 14.57421875 12.0546875 0.359375 11.22265625 1.7890625 0.703125 0.3515625 CN + 75tPA dAmax CN + 150tPA dAmax CFF dAmax CFF + TXA dAmax Patient ID (mm) (mm) (mm) (mm) CRT LY30 CN LY30 10092 1.0546875 1.125 0.5390625 0.6328125 0.02308093 0.009447213 10094 1.0546875 1.1015625 1.0078125 0.890625 0.029986443 0.02516742 10096 1.03125 1.1015625 0.5390625 0.609375 0.02673739 0.023091276 10098 1.3359375 1.2421875 0.5390625 0.3984375 0.028060208 0.025009675 10100 1.0078125 0.984375 0.65625 0.703125 0.032283943 0.019990945 10101 1.359375 1.3828125 0.9375 0.8203125 0.023396867 0.017267276 10103 1.3125 0.7265625 1.125 1.921875 0.019735192 0.020560912 10105 1.2421875 1.453125 0.75 0.6796875 0.0298312 0.028208719 10108 1.359375 1.5 0.65625 0.375 0.021454126 0.024958008 10109 1.640625 1.3828125 0.8203125 0.7265625 0.022353396 0.012313169 10110 1.3359375 1.40625 0.84375 0.75 0.022358013 0.020903184 10111 1.734375 1.96875 1.078125 0.8203125 0.022739705 0.01260451 10112 0.5625 0.84375 0.890625 0.0703125 0.879012492 0.027216533 10113 0.234375 0.46875 4.1015625 0.28125 0.046618911 0.009909361 CN + 75tPA CN + 150tPA CFF + TXA CN + 75tPA CN + 150tPA Patient ID LY30 LY30 CFF LY30 LY30 CRT CL30 CN CL30 CL30 CL30 10092 0.061420505 0.423262923 −1.74E−04 −0.029998471 0.95478601 0.973457274 0.8234894 0.033898305 10094 0.093868782 0.476873587 −0.017023738 −0.002700787 0.938390916 0.947052467 0.704015865 0.025269318 10096 0.022254736 0.04494031 0.002878275 −8.86E−04 0.94254849 0.94822627 0.946060094 0.883149569 10098 0.019210477 0.024390248 −0.011732456 −0.002473245 0.940722324 0.950413223 0.95467033 0.951698783 10100 0.064302843 0.563915151 −0.011968085 −0.023366468 0.93889019 0.960423027 0.812434994 0.002742494 10101 0.079153977 0.54122007 −0.005733012 −0.005837346 0.953537356 0.957810852 0.764648556 0.003959276 10103 0.068618434 0.441085434 0.011639684 −9.79E−04 0.955545102 0.951049749 0.800613121 0.050084034 10105 0.241447525 0.672740198 0.004960784 −0.00922619 0.934773634 0.940271493 0.317701785 0.002394493 10108 0.562259963 0.618193856 0.022240969 0.017528496 0.949289454 0.946223709 0.002127094 0.002118644 10109 0.035683892 0.524804696 −0.006783194 −2.86E−04 0.955635641 0.967517948 0.890828621 0.002124552 10110 0.021046184 0.180870505 0.016776178 0.009773535 0.940199336 0.954335119 0.955077211 0.406577693 10111 0.021232989 0.247648005 −0.016114207 −0.018321366 0.955622328 0.96779679 0.955553117 0.240700717 10112 0.072425928 0.479522205 0.002217401 0 0.001807286 0.932567433 0.805960437 0.014771261 10113 0.266667805 0.752061229 0.024084025 0.009252843 0.902624631 0.960064935 0.328871893 0.00530504 CFTX dV @ CFF max CN dV @ CN + tPA75 max CRT dA Integration to Acrit Patient ID CFF CL30 CFF + TXA CL30 (mm/min) (mm/min) (mm{circumflex over ( )}2) 10092 1.048175182 1.153027523 0.140625 0.28125 155.1560669 10094 1.058226336 1.009448819 0 0.703125 41.04217529 10096 1.012377023 1.001882648 0.140625 0.28125 137.9168701 10098 1.025506073 1.002349256 −0.140625 0.140625 18.10931396 10100 1.042253521 1.110785463 0 0.28125 30.77545166 10101 1.013483146 1.009630819 0.140625 0.28125 24.70935059 10103 0.987616951 1.175849941 0.140625 0.140625 148.2346802 10105 0.990294118 1.015306122 0.140625 0.28125 21.95892334 10108 0.952564597 0.962468724 0.140625 0.703125 9.876159668 10109 1.011545863 1.000974342 −0.140625 0.140625 41.13446045 10110 0.977374014 0.988277087 0.28125 0.140625 19.80834961 10111 1.036960986 1.055392732 0 0.140625 248.6063232 10112 0.999198932 1 0 0.140625 332.9483643 10113 0.935515388 0.984008529 −0.140625 0.5625 74.6619873 CN dA Integration to Acrit CN + 75tPA dA Integration to Acrit CN + 150tPA dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10092 153.1142578 148.8806763 155.2236328 10094 112.9405518 119.8833618 155.0736694 10096 152.5968018 114.3511963 138.5315552 10098 85.04241943 88.23614502 99.55096436 10100 142.5476074 103.4598999 133.3125 10101 126.7272949 113.6920166 106.6964722 10103 139.7114868 101.5993652 47.87127686 10105 119.911377 157.7796021 169.5179443 10108 112.7658691 135.2076416 114.6643066 10109 152.0645142 124.2454834 133.0438843 10110 116.5907593 93.62493896 127.8973389 10111 218.4060059 173.4334717 267.8873291 10112 130.4747314 66.29699707 118.8896484 10113 36.29608154 14.78869529 0.046142578 CFF dA CFF + TXA dA Integration to Acrit Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) ID SBP HR OR? ICU? Death? pRBC FFP PLT 10092 14.43109131 20.99981689 10092 210 128 No 0 No 0 0 0 10094 54.3147583 50.6184082 10094 128 100 Yes Yes No 0 0 0 10096 17.31170654 22.05615234 10096 100 96 Yes Yes No 0 0 0 10098 6.07598877 8.37322998 10098 108 112 No Yes No 0 0 0 10100 24.56433105 35.33862305 10100 Unk Unk Yes 0 No 0 0 0 10101 35.62536621 27.97064209 10101 110 110 Yes 0 No 0 0 0 10103 44.81103516 134.5023193 10103 123 92 No 0 No 0 0 0 10105 29.953125 20.06707764 10105 0 0 Yes Yes No 0 0 0 10108 8.041992187 7.827758789 10108 150 90 No Yes No 0 0 0 10109 18.23126221 18.26751709 10109 92 110 Yes Yes No 0 2 0 10110 25.58605957 21.515625 10110 100 92 Yes Yes No 0 0 0 10111 41.30090332 29.56256104 10111 115 70 No Yes No 0 0 0 10112 39.0135498 0.014831543 10112 210 142 No Yes No 0 0 0 10113 11.96575928 3.978149414 10113 110 110 No Yes No 0 0 0 Patient ID CRYO CN Crit Prod 10092 0 15.80566406 10094 0 14.43164063 10096 0 16.66113281 10098 0 9.175689697 10100 0 16.65087891 10101 0 14.7923584 10103 0 16.11190795 10105 0 13.43261719 10108 0 12.65332031 10109 0 16.86044312 10110 0 12.03414917 10111 0 24.11865234 10112 0 14.84179688 10113 0 5.123748779

TABLE 5 CRT Amax CN Amax CN + 75tPA Amax CN + 150tPA Amax CFF Amax CFF + TXA Amax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10027 55.7421875 58.625 43.1328125 19.3203125 19.015625 16.859375 10036 44.75 28.953125 5.703125 4.578125 11.703125 13.578125 10013 40.671875 42.9453125 18.0546875 13.203125 18.21875 17.9140625 10099 31.0859375 10.7421875 3.2421875 0.921875 9.96875 5.9609375 10107 52.3203125 42.734375 30.9453125 22.6484375 16.0390625 16.5546875 10093 51.125 54.8984375 40.5546875 26.3046875 12.3828125 13.6484375 10044 21.6171875 20.984375 14.0703125 2.1171875 4.5546875 9.453125 10068 47.84375 48.3359375 33.03125 16.9296875 7.4140625 10.8359375 10030 61.2265625 64.5078125 47.2578125 33.59375 22.015625 23.421875 10077 52.6015625 55.484375 51.0546875 40.765625 16.2265625 15.8046875 10075 46.203125 53.421875 44.8671875 27.6640625 21.0078125 19.7421875 10090 46.671875 45.6171875 31.859375 19.15625 9.0546875 10.203125 10059 60.6875 55.5546875 41.4453125 30.265625 15.1953125 18.03125 10061 52.8359375 58.7421875 55.15625 33.9921875 23.3046875 22.2734375 10097 50.5859375 56.7265625 52.6953125 32.1171875 19.1328125 16.8828125 10025 62.234375 70.203125 64.4375 51.8984375 22.765625 23.1640625 10050 53.4453125 59.8671875 53.9375 32.9609375 19.9765625 18.921875 10060 61.7890625 46.2734375 54.5 38.1171875 23 15.1484375 10032 59.7734375 61.6953125 52.6015625 45.9921875 20.9140625 19.4140625 10106 33.5 36.5 30.40625 12.453125 6.875 6.546875 10063 48.59375 64.7890625 63.3828125 53.375 23.0234375 21.640625 10088 63.5 59.984375 60.8046875 49.9296875 20.6796875 20.5625 10102 55.25 61.34375 48.4765625 22.6953125 10.71875 11.0703125 10115 72.5703125 70.5546875 68.7734375 51.5 27.8046875 27.640625 10014 62.515625 65.0234375 62.3046875 49.578125 18.640625 22.3671875 10085 64.0390625 69.453125 65.9609375 58.3671875 21.8984375 21.7109375 10047 62.703125 69.171875 61.015625 42.3828125 23.8203125 24.59375 10051 66.078125 68.65625 66.1015625 38.2109375 25.15625 24.078125 10056 61.859375 70.6015625 58.90625 52.4609375 25.578125 28.4609375 10057 67.5078125 68.1640625 64.15625 57.03125 25.6015625 26.46875 10039 65.09375 67.1796875 62.84375 56.2109375 21.96875 22.0859375 10067 58.484375 61.1328125 52.7890625 44.609375 22.203125 21.8046875 10071 55.2265625 56.703125 0.125 19.9765625 14.234375 13.390625 10104 64.4609375 68 64.0859375 65.6796875 27.171875 26.234375 10001 56.84375 55.625 52.2265625 41.75 21.1953125 20.28125 10002 63.03125 64.2734375 63.921875 58.203125 26.28125 25.578125 10003 66.6875 67.53125 60.8046875 44.6796875 26.2578125 25.0859375 10004 46.203125 34.203125 22.7890625 16.6015625 14.9609375 20.984375 10005 56.5625 60.359375 58.7890625 47.796875 27.5234375 26.2578125 10006 63.8515625 62.2109375 59.0234375 39.4765625 23.7265625 23.4921875 10007 61.953125 65.5625 59.3515625 52.296875 35.75 25.0625 10008 70.1796875 60.734375 48.5703125 35.703125 32.46875 27.640625 10009 71.5390625 70.4375 65.9609375 48.828125 29.5859375 29.2109375 10010 59.046875 61.5078125 57.7109375 48.7578125 21.875 21.2890625 10011 68.4453125 66.03125 59.1640625 54.3828125 25.296875 24.5703125 10012 52.015625 46.7890625 32.4453125 26.5625 17.7734375 19.53125 10015 68.6796875 69.359375 64.5078125 54.8984375 27.5 25.6953125 10017 59.5625 62.84375 58.6953125 45.59375 21.171875 19.71875 CRT Acrit CN Arit CN + 75tPA Acrit CN + 150tPA Acrit CFF Acrit CFF + TXA Acrit Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10027 0.86328125 9.69921875 11.890625 7.44921875 1.49609375 1.53125 10036 1.25 10.75390625 2.7265625 3.67578125 1.61328125 1.56640625 10013 1.73046875 8.515625 7.578125 6.21875 4.1328125 4.390625 10099 0.76953125 6.6640625 2.0703125 0.2421875 0.6875 0.23046875 10107 1.625 7.07421875 9.37109375 7.61328125 1.37890625 2.234375 10093 1.53125 10.0390625 9.04296875 8.515625 1.26171875 1.0859375 10044 0.59375 6.16015625 2.80859375 1.54296875 0.359375 1.484375 10068 12.48828125 13.0859375 6.58203125 8.66796875 0.3125 32.9140625 10030 1.8359375 12.7578125 12.41796875 13.7890625 5.4453125 4.37890625 10077 1.82421875 8.0703125 5.50390625 6.18359375 1.015625 1.0390625 10075 3.04296875 5.3515625 7.015625 6.60546875 3.8984375 3.23046875 10090 5.05859375 9.83984375 9.3359375 6.51171875 1.15625 0.359375 10059 1.16796875 15.3359375 13.63671875 13.63671875 2.38671875 2.01171875 10061 15.78125 14.140625 11.84375 12.1015625 4.671875 5.1875 10097 1.16796875 9.4296875 7.77734375 8.140625 3.3828125 1.015625 10025 1.9296875 10.26171875 12.81640625 9.58203125 4.4140625 3.41796875 10050 12.03125 9.98046875 9.8984375 8.76171875 2.3984375 2.515625 10060 1.7890625 5.66796875 14.796875 10.4609375 4.16796875 3.69921875 10032 12.76953125 13.14453125 12.6640625 13.625 3.3828125 2.64453125 10106 0.9921875 4.84765625 5.234375 3.7578125 0.40625 0.4296875 10063 1.35546875 9.46484375 7.7890625 8.48046875 2.41015625 2.22265625 10088 13.51953125 16.61328125 16.015625 14.8671875 39.0546875 3.34765625 10102 14.0703125 12.6875 12.18359375 8.62109375 26.78515625 0.37109375 10115 12.91015625 17.87890625 17.328125 16.8125 4.16796875 4.23828125 10014 1.7421875 10.37890625 9.7578125 13.47265625 3.4765625 3.9921875 10085 1.68359375 13.16796875 12.27734375 13.4609375 4.07421875 4.40234375 10047 10.44921875 13.296875 13.19140625 13.6484375 5.421875 4.37890625 10051 2.0703125 14.26953125 15.1484375 14.57421875 5.55078125 4.25 10056 2.9609375 10.66015625 10.25 12.67578125 3.95703125 6.2890625 10057 3.2421875 11.65625 10.91796875 11.52734375 4.44921875 5.7265625 10039 2.38671875 12.875 9.6171875 10.28515625 1.6015625 2.99609375 10067 16.5546875 12.3359375 11.5859375 12.62890625 43.54296875 3.5703125 10071 0.79296875 9.3125 0.125 9.265625 2.3046875 2.046875 10104 2.890625 11.73828125 9.81640625 10.91796875 5.421875 4.91796875 10001 1.73046875 13.00390625 13.96484375 9.8046875 3.3828125 2.984375 10002 17.9375 14.3984375 12.34765625 12.95703125 3.93359375 4.47265625 10003 6.0546875 16.015625 15.16015625 14.0703125 6.3828125 6.1015625 10004 0.828125 16.25 10.51953125 5.234375 2.9609375 1.16796875 10005 1.3203125 11.84375 11.83203125 11.15234375 2.41015625 1.625 10006 1.8828125 14.97265625 13.80078125 10.390625 4.42578125 4.859375 10007 2.140625 11.84375 8.94921875 12.65234375 14.17578125 4.390625 10008 6.11328125 14.10546875 18.55859375 15.34765625 8.9609375 6.8046875 10009 8.55078125 19.51953125 21.13671875 15.55859375 5.03515625 6.453125 10010 34.51953125 10.42578125 12.91015625 10.3671875 4.82421875 3.13671875 10011 8.71484375 13.05078125 13.40234375 13.70703125 5.31640625 5.22265625 10012 1.7421875 12.03125 9.58203125 11.15234375 2.0234375 1.96484375 10015 1.77734375 14.97265625 16.00390625 14.22265625 6.265625 5.36328125 10017 1.96484375 13.77734375 15.2421875 13.02734375 3.78125 3.65234375 CRT dAmax CN dAmax CN + 75tPA dAmax CN + 150tPA dAmax CFF dAmax CFF + TXA dAmax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10027 0.7734375 1.0078125 0.9375 0.8203125 0.8203125 0.28125 10036 1.078125 0.4921875 0.1875 0.1640625 1.1015625 0.2578125 10013 1.1484375 0.5625 0.515625 0.609375 0.5625 0.421875 10099 0.5390625 0.140625 0.09375 0.046875 0.515625 0.1171875 10107 0.795875 0.4453125 0.5859375 0.7265625 0.7265625 0.46875 10093 0.84375 0.84375 0.8203125 0.84375 0.3515625 0.234375 10044 0.421875 0.3046875 0.3515625 0.0703125 0.1875 0.28125 10068 0.4921875 0.515625 0.5859375 0.4921875 0.140625 0.140625 10030 1.171875 1.40625 1.4765625 1.3125 0.796875 0.8671875 10077 1.5703125 0.9375 1.0546875 1.2421875 0.703125 0.65625 10075 1.7578125 1.03125 1.078125 1.0546875 0.75 0.6328125 10090 0.5390625 0.4921875 0.46875 0.4921875 0.140625 0.234375 10059 1.0078125 0.703125 0.7265625 0.6796875 0.2578125 0.2109375 10061 1.545875 1.078125 1.125 0.984375 0.796875 0.65625 10097 0.9140625 0.9375 1.1953125 0.890625 1.03125 0.703125 10025 1.734375 1.6640625 1.6171875 1.6640625 0.9375 0.9609375 10050 0.75 1.0546875 1.078125 1.0078125 0.515625 0.421875 10060 1.734375 0.3046875 0.890625 0.984375 0.7734375 0.3046875 10032 1.0546875 1.0546875 1.078125 1.078125 0.703125 0.5859375 10106 0.5625 0.3984375 0.375 0.421875 0.140625 0.234375 10063 1.0078125 1.1953125 1.125 1.1953125 0.4453125 0.3515625 10088 0.8671875 0.6328125 0.65625 0.703125 0.5625 0.3515625 10102 0.515625 0.65625 0.5859375 0.5859375 0.1640625 0.2109375 10115 0.8671875 0.7734375 0.890625 0.65625 0.6796875 0.7265625 10014 0.9375 1.1953125 1.40625 0.5859375 0.609375 0.609375 10085 1.6171875 1.4296875 1.4296875 1.265625 1.0546875 0.7265625 10047 7.3828125 1.265625 1.4296875 1.171875 0.609375 0.7265625 10051 1.359375 1.4765625 1.78125 0.9609375 0.8203125 0.609375 10056 1.6875 1.4296875 1.3125 1.2890625 0.7265625 1.125 10057 1.875 1.921875 1.8984375 1.8984375 0.9609375 1.078125 10039 1.2890625 1.03125 1.265625 1.2421875 0.796875 0.7734375 10067 0.75 0.75 0.5625 0.8203125 39.2578125 0.5625 10071 0.7265625 0.515625 0 0.515625 0.234375 0.1875 10104 1.545875 1.3359375 1.7109375 1.6171875 0.984375 0.9140625 10001 1.4296875 0.6796875 0.7265625 0.65625 0.46875 0.515625 10002 0.75 0.984375 1.1484375 1.0078125 0.5390625 0.4921875 10003 1.40625 1.078125 1.3359375 1.3125 0.984375 0.84375 10004 0.703125 0.515625 0.5390625 0.46875 0.75 0.5859375 10005 1.03125 0.984375 1.0546875 1.0078125 1.8515625 1.3125 10006 1.546875 0.9609375 1.1484375 1.21875 0.7734375 0.5625 10007 1.453125 1.171875 1.2890625 1.1953125 2.0859375 0.84375 10008 1.3828125 0.6796875 0.4453125 0.5390625 0.9375 0.609375 10009 1.5703125 1.1015625 1.0078125 0.8671875 0.7265625 0.75 10010 2.2734375 1.0546875 1.1015625 1.078125 0.8203125 1.5703125 10011 1.4296875 0.8671875 0.8671875 1.1484375 0.5390625 0.4921875 10012 0.9375 1.03125 1.0078125 0.9140625 1.5 1.2890625 10015 1.2890625 1.0546875 1.0546875 0.9140625 0.5625 0.5859375 10017 1.3359375 0.7734375 0.890625 0.8671875 0.375 0.2578125 CN + 75tPA CN + 150tPA CFF + TXA Patient ID CRT LY30 CN LY30 LY30 LY30 CFF LY30 LY30 CRT CL30 CN CL30 10027 0.032181149 0.036531072 0.610296293 0.877309947 0.001396878 −0.018850402 0.912123336 0.934834755 10036 0.620687849 0.570174492 0.883573059 0.90988339 0.723025145 −0.033342923 0.003840782 0.007555316 10013 0.122440453 0.17333015 0.764863695 0.920766765 0.18963098 −0.028770534 0.593161736 0.525195561 10099 0.700512063 0.676866667 0.862426372 0.803248588 0.741447884 −0.040334207 0.005529027 0.022545455 10107 0.206567617 0.301307892 0.721292673 0.869580028 0.486720653 −0.010193487 0.418545617 0.257952468 10093 0.157658839 0.205500806 0.659639012 0.875379913 0.443278128 −0.036288399 0.524144254 0.459086381 10044 0.795071377 0.8215557 0.874518786 0.844049815 0.814686964 −0.038434343 0.005782436 0.007073716 10068 0.413549604 0.333138705 0.684876616 0.863611367 0.646364594 −0.02922074 0.111365121 0.201390011 10030 0.049018013 0.048666115 0.5668166 0.87458624 0.190315235 −0.015613187 0.874441751 0.840135642 10077 0.104187707 0.107589411 0.630032517 0.814858822 0.300028085 0.030363322 0.632407545 0.656153196 10075 0.013590398 0.005073974 0.66195731 0.882000141 −0.01578034 −0.017857143 0.97717281 0.983767183 10090 0.273513001 0.251932409 0.654669364 0.873151169 0.479155882 −0.01954441 0.329092735 0.370097619 10059 0.403412504 0.205224691 0.634131061 0.750124763 0.628603256 −0.01975195 0.048403708 0.434256785 10061 0.01238212 0.016334176 0.341356822 0.715671685 0.025839479 0.022295783 0.976489723 0.968080862 10097 0.013837838 0.020287418 0.295816654 0.749214506 −0.006116442 −0.006813975 0.967567568 0.959096543 10025 0.020103147 0.020015858 0.301405728 0.60935634 0.018522173 0.001226813 0.951041928 0.950255954 10050 0.017763607 0.016338611 0.239333478 0.692515011 −0.002336723 −0.001073493 0.960532086 0.967506199 10060 0.033260983 −0.087673758 0.297550929 0.694521589 0.009783552 −0.057673629 0.937792388 1.141820024 10032 0.079844138 0.07552534 0.051217676 0.417378452 −0.010187088 −0.006750503 0.859234087 0.875775611 10106 0.037628265 0.009302761 0.455055955 0.935377457 0.003082386 −0.075740851 0.907649254 0.969820205 10063 0.036809352 0.00174796 0.006560459 0.550600117 −0.008719319 −0.015025572 0.932958199 0.987338719 10088 0.033335384 0.038860489 0.074793888 0.391418053 0.013625488 −0.012183384 0.926181102 0.90974212 10102 0.013800905 0.004507344 0.562845152 0.848988812 5.16E−04 0.005384027 0.972002262 0.984717269 10115 −9.07E−04 0.00166233 0.072674562 0.491382863 −0.014777091 −0.013430375 0.99515556 0.991030894 10014 0.036194424 0.0174196 0.016686346 0.239035744 −0.001005868 9.21E−04 0.930642339 0.961792623 10085 0.012515249 0.014965317 0.019434574 0.426500617 −0.00628196 0.00456849 0.971818958 0.965579303 10047 0.015036548 0.023598091 0.31609724 0.653241935 0.028920684 0.002780866 0.961126339 0.940027106 10051 0.051359495 0.036818989 0.129969698 0.588880654 0.003277692 0.00937838 0.900685741 0.916021848 10056 0.040883465 0.030727841 0.049351606 0.304203276 0.009619986 6.10E−04 0.918161152 0.934270222 10057 0.02123211 0.019522923 0.097372578 0.54744863 0.002834147 0.001678309 0.952088879 0.952893983 10039 0.030087314 0.021265554 0.065426612 0.356663192 −8.83E−04  0.001954369 0.937710034 0.951157111 10067 0.024026887 0.023099042 0.127341193 0.52226187 −0.089839901 −0.023327959 0.949104996 0.947476038 10071 0.029964163 0.015405989 1 0.823419372 0.074108123 0.010054454 0.913000424 0.946266189 10104 0.02263059 0.016736079 0.473321752 0.343410253 0.015296147 0.009525346 0.954550964 0.960018382 10001 0.044339839 0.035448853 0.125558464 0.574256955 0.003027092 0.014933231 0.905992303 0.920365169 10002 0.020561684 0.01556089 0.025736373 0.048507271 −0.026026803 −0.025764865 0.952032722 0.970827762 10003 0.023201246 0.02049543 0.285959784 0.639335257 3.64E−04 −0.006207827 0.950445173 0.953840814 10004 0.673048416 0.667148241 0.766353845 0.823688235 0.835254569 −0.004840428 0.004734528 0.005025126 10005 0.06026761 0.049426 0.075513843 0.383931977 −0.028563488 −0.02444461 0.87859116 0.892052809 10006 0.034280048 0.006880259 0.121344584 0.527154661 0.009525573 0.010931438 0.93723235 0.979279166 10007 0.014223939 0.015482503 0.175179896 0.483857435 −0.017598157 −0.017704437 0.970870113 0.968898951 10008 0.040747338 0.03000636 0.186974559 0.347914843 −0.022982836 −0.014046307 0.914505176 0.936712117 10009 0.026999381 0.014878642 0.07481 0.452688 0.003454802 4.71E−04 0.941683958 0.963065661 10010 0.034516958 0.035916 0.153788562 0.578757411 −0.007364583 7.22E−04 0.926964806 0.919979677 10011 0.023568783 0.021000454 0.034518465 0.19155214 −0.013607937 −0.027164812 0.945896587 0.949952674 10012 0.490499524 0.474602744 0.691469018 0.849708333 0.680998168 −0.020095 0.024932412 0.07380197 10015 0.021365601 0.017188087 0.094819042 0.270578957 −0.007755682 −0.005489257 0.950176317 0.959788241 10017 0.06030463 0.016644911 0.081614091 0.569954211 −0.001500615 −0.048368991 0.883525708 0.958975634 CFTX dV @ CFF max Patient ID CN + 75tPA CL30 CN + 150tPA CL30 CFF CL30 CFF + TXA CL30 (mm/min) 10027 0.003984785 0.006469875 0.98767461 1.029193698 0 10036 0.021917808 0.027303754 0.010680908 1.058688147 0.421875 10013 0.008221549 0.011242604 0.428816467 1.064108155 0.28125 10099 0.038554217 0.13559322 0.202978056 1.086500655 0.28125 10107 0.004039384 0.007588824 0.054554311 1.022652194 0.421875 10093 0.003660181 0.004752005 0.14637224 1.077275329 0.140625 10044 0.010549695 0.05904059 0.027444254 1.084297521 0.28125 10068 0.005203406 0.007383479 0.035827187 1.080028839 0.5625 10030 0.003636965 0.004418605 0.444286728 1.030020013 0.140625 10077 0.002448355 0.003066309 0.254694271 0.922886802 0.28125 10075 0.002786 0.004518498 1.033469691 1.035615354 0 10090 0.00980873 0.006525285 0.119930975 1.036753446 0.28125 10059 0.003016023 0.004130098 0.028277635 1.035095321 0.28125 10061 0.085127479 0.003677316 0.954743547 0.967379867 0.140625 10097 0.217642698 0.003891997 1.013474888 1.011105969 0 10025 0.20271581 0.00240855 0.963967056 0.998988196 0.140625 10050 0.334733488 0.003792368 1.0023465 1.002477291 0 10060 0.236238532 0.003279361 0.991847826 1.103661681 0.140625 10032 0.882370414 0.040428062 1.016809862 1.014486922 0 10106 0.063463515 0.010037641 0.928409091 1.132458234 0 10063 0.974855171 0.00234192 1.00916186 1.022743682 0 10088 0.789926763 0.08699734 0.984132981 1.036474164 0.140625 10102 0.002578566 0.005507745 1.008746356 0.993648553 0 10115 0.776780643 0.017445388 1.048890138 1.028829847 0.140625 10014 0.966520376 0.34714781 1.015088013 0.996856444 0 10085 0.957005804 0.040289118 1.019265073 0.994602375 0 10047 0.18950064 0.002949309 0.914398163 0.999047014 0.140625 10051 0.617421109 0.013085259 0.999068323 0.985399091 0 10056 0.842838196 0.175725987 0.978924863 1.000823497 0.140625 10057 0.667924988 0.003013699 0.995422643 1.001770956 0 10039 0.806439582 0.131063238 0.997866287 0.997877609 0 10067 0.636821074 0.004378284 1.329345531 1.064493013 −0.140625 10071 1 0.009777083 0.761251372 0.982497083 0.140625 10104 0.007070584 0.101463066 0.9706728 0.991066111 0.140625 10001 0.639192221 0.003555389 0.990047917 0.969953775 0 10002 0.939868003 0.883221477 1.070451843 1.076053757 0 10003 0.20441989 0.003322259 0.998214817 1.026160075 0.140625 10004 0.005485087 0.007529412 0.008355091 1.048026806 0.84375 10005 0.809435216 0.128636809 1.04513199 1.037488843 0.140625 10006 0.615618795 0.003166436 0.981231478 0.983039574 0.140625 10007 0.515861524 0.023453839 1.029501748 1.04021197 0.421875 10008 0.529515844 0.214223195 1.054860443 1.038157151 0 10009 0.794978088 0.02848 0.995246897 1.005616475 0.140625 10010 0.568701773 0.005447845 1.0225 1.008807339 0 10011 0.914828998 0.496624048 1.03428042 1.072496025 0 10012 0.003852637 0.004705882 0.007032967 1.0348 0.5625 10015 0.737313794 0.369005265 1.025568182 1.020979021 0 10017 0.768401438 0.002741604 1 1.199683043 0 CN dV @ CN + tPA75 max CRT dA Integration to Acrit CN dA Integration to Acrit Patient ID (mm/min) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10027 0.84375 4.167663574 85.9520874 10036 3.65625 3.351928711 35.29083252 10013 2.953125 0.851989746 30.48376465 10099 1.6875 0.16973877 7.577270508 10107 1.546875 0.385620117 19.28265381 10093 1.265625 0.853637695 56.30053711 10044 1.96875 0.402099609 18.49493408 10068 1.96875 55.67266846 57.52990723 10030 1.96875 0.866821289 124.614624 10077 0.84375 0.374084473 54.78771973 10075 0.84375 45.57073975 46.79187012 10090 1.40525 13.43243408 25.65362549 10059 1.546875 1.507873535 84.42773438 10061 0.140625 158.5063477 129.7397461 10097 0.28125 7.57232666 77.203125 10025 0.421875 24.0534668 150.218811 10050 0.28125 71.05297852 81.03790283 10060 0.84375 21.12670898 14.2399292 10032 0.5625 144.5267944 95.99468994 10106 0.5625 4.676879883 18.36639404 10063 0.140625 10.36724854 70.71185303 10088 0.140625 108.4498901 94.48846436 10102 0.984375 60.84887695 56.65649414 10115 0.28125 85.81365967 121.9993286 10014 0 13.54943848 111.3931274 10085 0.140625 18.49822998 173.6295776 10047 0.5625 685.0376587 147.9067383 10051 0.28125 22.11547852 186.1671753 10056 0.421875 44.68249512 126.6663208 10057 0.140625 50.58215332 200.618042 10039 0.28125 27.48944092 123.7412109 10067 0.421875 130.4022217 79.40478516 10071 1.125 3.468933105 37.39196777 10104 0.703125 40.84606934 138.3964233 10001 0.28125 18.53118896 75.84356689 10002 0.421875 33.03479004 134.4034424 10003 0.84375 88.00708008 157.7351074 10004 3.65625 0.405395508 75.09375 10005 0.28125 10.16784668 105.791748 10006 0.28125 22.12866211 92.40875244 10007 0.421875 25.69812012 125.6231689 10008 0.421875 79.16253662 75.42169189 10009 0.28125 126.6432495 176.0454712 10010 0.421875 342.4257202 90.99481201 10011 0.140625 120.1107788 102.0822144 10012 2.671875 1.974243164 84.82324219 10015 0.140625 16.7744751 146.3724976 10017 0.28125 21.30633545 94.42584229 CN + 75tPA dA Integration to Acrit CN + 150tPA dA Integration to Acrit CFF dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10027 101.4642334 45.04669189 10.11346436 10036 3.318969727 5.532165527 5.04107666 10013 26.18261719 28.65124512 2.231323242 10099 1.272216797 0.019775391 0.260375977 10107 41.2300415 48.57000732 0.393859863 10093 62.28094482 61.1685791 0.271911621 10044 7.592102051 0.552062988 0.052734375 10068 26.35565186 37.64080811 0.046142578 10030 154.8099976 178.7167969 18.28894043 10077 52.32073975 70.82391357 0.283447266 10075 69.48083496 39.81280518 29.9630127 10090 35.08813477 22.11383057 0.177978516 10059 79.0010376 80.16778564 2.480163574 10061 115.2773438 100.2183838 35.8560791 10097 74.16265869 68.04382324 30.8001709 10025 161.7544556 138.9138794 38.51916504 10050 91.74462891 71.90496826 11.390625 10060 119.973999 86.43164063 25.09991455 10032 120.9364014 131.7700195 20.671875 10106 10.99182129 13.90209961 0.385620117 10063 78.4588623 91.31121826 10.2288208 10088 91.61279297 64.3458252 49.21435547 10102 65.57684326 44.1897583 19.89239502 10115 85.35388184 97.12023926 19.7210083 10014 118.4084473 66.15362549 15.51049805 10085 155.5900024 159.0864258 35.84454346 10047 162.7630005 143.6055908 25.88598633 10051 231.9521484 107.1282349 40.11602783 10056 54.03625488 143.7094116 25.6206665 10057 164.661438 188.5501099 38.38238525 10039 88.77832031 101.6867065 10.98852539 10067 48.34094238 90.79046631 103.7993774 10071 0 39.15856934 4.624145508 10104 144.7278442 159.5033569 47.8861084 10001 60.63299561 53.13317871 13.2989502 10002 122.3388062 120.6018677 17.91815186 10003 175.6664429 143.7802734 55.2557373 10004 51.08477783 17.79125977 7.280639648 10005 104.5079956 97.47784424 35.14910889 10006 124.972229 106.2235107 32.91778564 10007 73.32220459 135.4202271 273.8776245 10008 47.03411865 63.8102417 73.72595215 10009 181.0288696 114.6494751 28.65618896 10010 116.6401978 93.13879395 35.91375732 10011 104.9727173 72.57733154 25.35040283 10012 82.31671143 86.3838501 19.26452637 10015 146.1582642 81.92449951 29.44885254 10017 128.0390625 101.446106 12.61669922 CFF + TXA dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) ID SBP HR OR? ICU? Death? pRBC FFP PLT CRYO CN Crit Prod 10027 4.268188477 10027 150 Unk Yes Yes Yes 61 12 2 6 9.774993896 10036 3.314025879 10036 0 0 Yes Yes No 32 8 3 4 5.292938232 10013 16.37072754 10013 96 100 Yes Yes Yes 29 16 5 0 4.790039063 10099 0.087341309 10099 80 120 Yes Yes Yes 27 12 4 6 0.937133789 10107 9.271362305 10107 0 130 Yes Yes Yes 24 13 2 2 3.150238037 10093 0.557006836 10093 70 140 Yes Yes No 23 12 2 2 8.470458984 10044 3.348632813 10044 140 93 Yes Yes No 21 12 1 1 1.876922607 10068 18.60534668 10068 160 70 No Yes Yes 14 12 2 1 6.747436523 10030 30.75897217 10030 180 40 Yes Yes Yes 12 8 2 1 17.94067383 10077 5.164672852 10077 0 110 Yes Yes No 11 4 1 0 7.565917969 10075 18.2477417 10075 100 100 Yes Yes No 9 4 2 0 5.518798828 10090 0.411987305 10090 Unk Unk Yes Yes No 9 4 2 2 4.843048096 10059 3.093200684 10059 180 150 Yes Yes Yes 8 6 1 2 10.78308105 10061 32.24707031 10061 108 112 Yes Yes No 7 6 2 0 15.24536133 10097 5.164672852 10097 104 130 Yes Yes No 7 4 1 0 8.840332031 10025 28.14532471 10025 204 102 Yes Yes Yes 6 4 1 1 17.07614136 10050 10.31945801 10050 107 89 Yes Yes No 6 4 1 0 10.52627563 10060 8.211730957 10060 70 112 Yes Yes No 6 3 0 0 1.726959229 10032 13.52142334 10032 0 0 Yes Yes No 5 6 1 0 13.8633728 10106 0.639404297 10106 0 122 Yes Yes No 5 3 0 0 1.931488037 10063 6.98236084 10063 80 100 Yes Yes No 4 2 1 0 11.31344604 10088 11.0725708 10088 102 110 Yes Yes No 4 4 1 0 10.51309204 10102 0.430114746 10102 122 90 Yes Yes Yes 4 5 2 2 8.326171875 10115 26.19085693 10115 102 130 Yes Yes <28 d 4 4 2 0 13.82821655 10014 20.10827637 10014 80 110 Yes Yes No 3 1 0 0 12.40603638 10085 24.3583374 10085 132 108 Yes Yes No 3 0 0 0 18.82608032 10047 27.24554443 10047 0 120 Yes Yes No 2 1 0 0 16.82885742 10051 22.52087402 10051 110 124 Yes Yes No 2 0 0 0 21.06985474 10056 60.17321777 10056 108 100 Yes Yes No 2 0 0 0 15.24069214 10057 52.54980469 10057 90 130 Yes Yes No 2 2 0 0 22.40185547 10039 21.26019287 10039 140 120 Yes Yes No 1 0 0 0 13.27734375 10067 16.0378418 10067 100 120 Yes Yes No 1 0 0 0 9.251953125 10071 2.059936523 10071 90 80 Yes Yes No 1 2 0 1 4.801757813 10104 30.43267822 10104 100 72 Yes Yes No 1 0 0 0 15.68161011 10001 13.25280762 10001 132 90 No 0 No 0 0 0 0 8.838592529 10002 20.62738037 10002 110 110 Yes 0 No 0 0 0 0 14.17346191 10003 47.34228516 10003 118 120 Yes Yes No 0 0 0 0 17.2668457 10004 5.617858887 10004 0 0 No Yes No 0 0 0 0 8.37890625 10005 15.49072266 10005 124 120 Yes 0 No 0 0 0 0 11.65869141 10006 21.35083008 10006 60 86 No 0 No 0 0 0 0 14.38778687 10007 30.1673584 10007 98 66 Yes Yes No 0 2 0 0 13.87939453 10008 37.30297852 10008 84 90 Yes 0 No 0 0 0 0 9.587310791 10009 37.08874512 10009 72 112 Yes Yes No 0 0 0 0 21.50198364 10010 45.75531006 10010 Walk-in Walk-in No 0 No 0 0 0 0 10.99594116 10011 20.23187256 10011 124 72 Yes 0 No 0 0 0 0 11.31747437 10012 20.21868896 10012 0 0 No Yes Yes 0 0 0 0 12.40722656 10015 28.83416748 10015 122 112 Yes Yes No 0 0 0 0 15.79147339 10017 9.226867676 10017 80 116 Yes Yes No 0 0 0 0 10.65591431 Patient ID 10027 10036 10013 10099 10107 10093 10044 10068 10030 Bad HF but good launch and MA 10077 10075 10090 SH but not MH and serious HF 10059 10061 10097 10025 10050 10060 SH but not MH 10032 10106 SH but not MH, also some HF 10063 10088 10102 10115 10014 10085 10047 10051 10056 10057 10039 10067 10071 Low launch, some HF 10104 10001 10002 10003 10004 10005 10006 10007 10008 10009 10010 10011 10012 10015 10017 CRT Amax CN Amax CN + 75tPA Amax CN + 150tPA Amax CFF Amax CFF + TXA Amax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10019 67.765625 68.9609375 62 52.015625 27.8046875 25.765625 10020 68.9609375 66.2890625 62.890625 51.828125 23.8671875 23.328125 10022 59.890625 64.4140625 59.84375 61.0859375 22.296875 19.7421875 10023 63.1015625 68.4453125 55.6015625 35.3046875 32.234375 32.5390625 10024 62.46875 66.8984375 57.8515625 38.6796875 22.203125 20.46875 10026 51.6875 50.515625 52.7421875 26.5859375 13.90625 13.7890625 10028 64.0390625 69.59375 66.6171875 57.8984375 27.640625 26.84375 10029 65.6796875 65.140625 47.84375 29.421875 25.1328125 26.375 10031 61.8359375 61.1796875 49.0625 33.6640625 23.8203125 24.0078125 10033 62.0234375 66.59375 57.9453125 42.1484375 24.5234375 24.2421875 10034 60.640625 57.6875 43.0625 31.1796875 20.609375 17.8203125 10035 56.65625 60.5 52.6015625 47.0234375 20.046875 19.671875 10037 66.40625 70.53125 66.875 62.46875 25.25 24.6640625 10038 60.8046875 58.625 51.7578125 51.0546875 23.0234375 24.8046875 10040 65.5859375 61.2265625 49.296875 46.6484375 25.8125 23.65625 10041 59.140625 63.546875 55.203125 35.3515625 21.1953125 21.0546875 10042 62.75 63.78125 56.5859375 44.28125 22.9296875 21.4765625 10043 62.8671875 64.015625 54.6640625 36.640625 19.765625 19.6953125 10045 62.65625 63.171875 48.171875 25.6484375 27.9921875 23.703125 10046 49.6953125 55.7890625 51.40625 31.578125 19.15625 17.65625 10048 74.703125 73.8828125 65.890625 56.1171875 31.6953125 34.484375 10049 58.7421875 62.609375 55.4140625 49.859375 19.6484375 17.984375 10052 71.796875 70.2734375 67.0390625 35.234375 31.34375 29.3984375 10053 65.5625 66.359375 62.0703125 57.6171875 24.2421875 23.5859375 10054 59.4453125 59.9375 50.4921875 41.65625 21.4765625 21.1484375 10055 66.40625 66.21875 48.2890625 50.7734375 28.671875 26.84375 10058 57.8984375 58.7890625 50.84375 32.609375 21.6171875 20.84375 10062 62.5859375 64.7421875 63.40625 58.9765625 25.4375 24.4765625 10064 72.78125 71.8671875 72.6640625 66.1953125 36.40625 34.9296875 10065 57.0546875 58.25 49.203125 35.3984375 21.2421875 22.15625 10069 65.5625 69.9921875 70.8125 69.9453125 28.8125 28.4375 10070 48.546875 58.34375 52.9296875 46.1328125 17.2578125 15.6875 10072 67.9765625 64.25 63.8515625 54.921875 21.078125 22.203125 10073 72.078125 73.8828125 71.984375 28.5078125 31.9296875 93.78125 10074 64.7890625 67.7890625 62.328125 51.265625 20.140625 20.515625 10076 63.8984375 66.125 59.84375 49.765625 23.09375 23.375 10078 68.2578125 65.4921875 61.2734375 52.3203125 27.734375 26.28125 10079 70.1328125 71.6328125 67.8828125 41.4921875 40.0390625 31.0625 10080 56.0234375 55.859375 56.75 36.8515625 18.2421875 16.4609375 10081 69.3359375 68.46875 67.296875 62.984375 27.4765625 25.4375 10082 53.703125 51.40625 54.9921875 53.3515625 20.1171875 18.8515625 10083 58.6015625 62.328125 61.6484375 55.15625 25.15625 22.390625 10084 63.640625 65.2578125 63.4765625 57.4765625 27.265625 26.1875 10086 65.65625 64.6953125 62.75 46.3671875 26.234375 24.5703125 10087 70.34375 66.59375 66.6875 59.046875 31.625 33.9453125 10089 63.40625 72.1953125 68.2578125 60.0078125 27.171875 28.4609375 10092 67.90625 69.7578125 68.9140625 61.765625 21.40625 21.2890625 10094 64.671875 65.0703125 63.03125 58.7421875 26.1640625 24.8046875 CRT Acrit CN Arit CN + 75tPA Acrit CN + 150tPA Acrit CFF Acrit CFF + TXA Acrit Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10019 2.36328125 16.12109375 13.66015625 9.0078125 1.484375 4.4140625 10020 2.2109375 16.37890625 14.1171875 13.44921875 4.80078125 5.31640625 10022 1.1796875 11.046875 10.49609375 12.39453125 1.3203125 1.1796875 10023 11.01171875 16.51953125 13.0625 13.0625 4.4140625 6.58203125 10024 1.1796875 6.78125 18.69921875 10.484375 3.921875 3.265625 10026 11.41015625 10.56640625 8.7734375 7.89453125 0.32421875 1.671875 10028 1.484375 14.65625 15.8046875 14 3.4765625 3.67578125 10029 7.09765625 16.47265625 10.625 13.8125 4.14453125 4.21484375 10031 14 12.46484375 12.65234375 11.84375 2.10546875 3.875 10033 1.75390625 13.87109375 15.93359375 13.21484375 5.84375 5.09375 10034 14.33984375 12.69921875 13.84765625 9.16015625 0.8515625 2.609375 10035 1.89453125 10.390625 8.46875 7.84765625 4.35546875 2.85546875 10037 1.859375 14.46875 15.5234375 13.015625 4.19140625 4.58984375 10038 4.28515625 12.265625 16.4375 14.4921875 3.79296875 5.69140625 10040 6.55859375 11.59765625 10.98828125 17.03515625 6.37109375 5.75 10041 1.14453125 14.046875 8.1640625 9.98046875 3.25390625 3.21875 10042 2.1875 14.234375 14.69140625 10.3203125 4.16796875 3.3125 10043 4.77734375 13.30859375 15.3359375 12.44140625 5.31640525 4.56640625 10045 12.1015625 13.2734375 12.0546875 9.40625 7.109375 5.7265625 10046 0.8984375 7.77734375 6.67578125 7.671875 2.3046875 1.90625 10048 7.84765625 14.984375 21.37109375 14.97265625 8.57421875 8.64453125 10049 14.66796875 11.4453125 11.328125 11.71484375 3.83984375 2.9140625 10052 7.578125 15.1953125 18.3359375 11.69140625 6.21875 4.49609375 10053 1.6953125 15.39453125 13.05078125 11.1171875 4.1328125 4.82421875 10054 12.96875 12.11328125 12.0078125 14.3515625 3.9453125 3.6875 10055 6.16015625 13.28515625 9.04296875 12.76953125 7.54296875 6.734375 10058 2.09375 11.69140625 9.5234375 11.1171875 4.42578125 3.04296875 10062 1.28515625 14.4921875 12.30078125 12.0546875 4.109375 4.90625 10064 5.73828125 12.9921875 14.45703125 14.80859375 5.73828125 5.421875 10065 4.15625 12.453125 6.51171875 9.1015625 4.12109375 5.48046875 10069 2.7265625 15.76953125 14.50390625 14.8203125 5.90234375 6.18359375 10070 1.56640625 9.8984375 8.99609375 10.77734375 2.45703125 15.96875 10072 13.26171875 15.55859375 15.125 14.87890625 5.140625 3.60546875 10073 7.0859375 15.37109375 16.859375 20.57421875 7.5078125 46.75390625 10074 1.58984375 11.1875 8.94921875 9.0078125 3.13671875 2.90234375 10076 2.66796875 14.3515625 17.6328125 13.75390625 4.49609375 4.484375 10078 7.765625 19.21484375 14.7734375 15.2421875 6.078125 6.40625 10079 2.48046875 10.98828125 12.11328125 14.2109375 11.046875 5.22265625 10080 11.69140625 12.58203125 10.58984375 12.32421875 4.15625 19.30859375 10081 17.10546875 15.95703125 15.828125 18.55859375 7.4140625 5.24609375 10082 2.1171875 15.2890625 14.85546875 13.8359375 4.87109375 3.875 10083 2.43359375 10.89453125 10.6953125 10.33203125 4.15625 3.46484375 10084 6.23046875 14.65625 12.546875 12.20703125 4.8125 4.70703125 10086 17.796875 17.703125 17.234375 14.2578125 5.796875 4.28515625 10087 14.03515625 19.0625 26.41015625 19.47265625 7.23828125 7.40234375 10089 3.2421875 12.5703125 11.64453125 10.6484375 5.03515625 8.2578125 10092 17.76171875 16.859375 16.70703125 14.65625 3.76953125 3.72265625 10094 2.48046875 12.828125 14.29296875 15.53515625 6.25390625 6.21875 CRT dAmax CN dAmax CN + 75tPA dAmax CN + 150tPA dAmax CFF dAmax CFF + TXA dAmax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10019 1.6640625 1.1953125 1.1953125 1.125 1.5 0.703125 10020 1.359375 0.8671875 0.890625 0.8203125 0.5390625 0.5390625 10022 0.984375 0.9375 0.8203125 1.0546875 0.9375 0.796875 10023 1.5234375 1.1953125 0.9375 0.46875 1.03125 1.1953125 10024 0.9375 1.171875 0.9140625 1.078125 0.515625 0.421875 10026 0.7265625 0.8203125 0.9375 0.8203125 0.1640625 0.140625 10028 1.40625 1.40625 1.40625 1.40625 0.84375 0.8671875 10029 1.2421875 0.7265625 0.609375 0.421875 0.8671875 0.8671875 10031 1.21875 1.1015625 1.0078125 0.890625 1.1953125 0.46875 10033 1.1015625 0.8671875 0.8671875 0.8203125 0.796875 0.75 10034 0.8203125 0.8203125 0.6328125 0.6796875 0.5625 0.375 10035 1.3828125 1.03125 0.9375 1.0546875 0.8203125 0.6328125 10037 1.546875 1.5 1.5 1.5 0.8671875 0.7734375 10038 1.1484375 0.65625 0.515625 0.609375 0.9140625 1.0546875 10040 1.1484375 0.6796875 0.4453125 0.6796875 0.9609375 0.890625 10041 0.8671875 0.9375 1.03125 0.8203125 0.6328125 0.5625 10042 1.125 1.03125 1.1953125 1.265625 0.8671875 0.703125 10043 0.9609375 1.0546875 0.984375 1.0078125 0.5859375 0.6796875 10045 0.984375 1.03125 0.75 0.703125 1.171875 0.75 10046 0.796875 1.1015625 1.1484375 1.125 0.421875 0.328125 10048 1.9453125 1.640625 1.1015625 1.2421875 0.9609375 1.1484375 10049 0.8671875 0.9375 0.9375 0.8671875 0.5390625 0.375 10052 1.359375 1.21875 1.3125 0.7265625 0.796875 0.5859375 10053 1.6875 1.1015625 1.1953125 1.125 0.65625 0.6796875 10054 0.890625 0.7734375 0.703125 0.75 0.421875 0.421875 10055 1.3359375 1.0546875 1.0546875 1.1953125 1.1484375 0.9375 10058 1.734375 1.0546875 1.125 1.03125 0.6796875 0.4921875 10062 1.1953125 0.796875 0.8671875 0.890625 0.703125 0.65625 10064 1.5234375 1.359375 1.5234375 1.4765625 1.1015625 1.078125 10065 1.03125 0.75 0.9609375 1.03125 0.9140625 0.8203125 10069 2.295875 1.4296875 1.6171875 1.453125 0.9140625 0.8671875 10070 0.8203125 0.984375 0.9609375 1.0078125 0.4453125 1.078125 10072 1.3359375 0.9140625 1.171875 1.1015625 0.46875 0.4921875 10073 4.03125 1.8984375 2.203125 5.0859375 1.171875 3.1640625 10074 1.1015625 1.21875 1.5703125 1.3125 0.5859375 0.5390625 10076 2.0390625 1.171875 1.078125 0.9609375 0.6796875 0.609375 10078 1.875 1.1484375 1.171875 1.078125 1.171875 0.984375 10079 2.2265625 1.9921875 2.1796875 2.296875 2.953125 1.2421875 10080 0.8671875 0.4921875 0.8203125 0.7734375 0.515625 3.1171875 10081 1.4765625 1.0546875 1.171875 1.0078125 0.9375 0.5859375 10082 1.734375 0.515625 0.6796875 0.5625 0.4453125 0.46875 10083 1.7109375 1.0546875 1.40625 1.5703125 1.03125 0.6328125 10084 1.8046875 1.265625 1.3125 1.3828125 0.9375 0.9140625 10086 0.84375 0.703125 0.75 0.609375 0.75 0.5859375 10087 1.2890625 0.796875 0.9609375 0.6328125 0.5390625 0.8671875 10089 1.96875 2.15625 2.2265625 1.453125 1.1015625 2.15625 10092 0.9609375 0.9375 1.0546875 1.125 0.5390625 0.6328125 10094 2.2734375 1.125 1.0546875 1.1015625 1.0078125 0.890625 CN + 75tPA CN + 150tPA CFF + TXA Patient ID CRT LY30 CN LY30 LY30 LY30 CFF LY30 LY30 CRT CL30 CN CL30 10019 0.018560257 0.022788509 0.100859305 0.454886769 0.003487637 −0.009435011 0.957804934 0.950039651 10020 0.030007206 0.014039481 0.060452899 0.432118003 −0.003161484 −0.006205347 0.947320721 0.965350619 10022 0.015688864 0.01108298 0.011277198 0.026278403 0.04736335 0.043820077 0.962822854 0.970527592 10023 0.050798564 0.02016465 0.106925905 0.536037656 0.001784416 0.006433573 0.900829516 0.94966328 10024 0.051351544 0.03619448 0.432249981 0.633892143 0.02721235 0.135655746 0.900575288 0.918019386 10026 0.0408322 0.045881663 0.128821656 0.681686502 −0.007343165 −0.002573182 0.912031439 0.903495206 10028 0.036332229 0.01844581 0.070189301 0.48095455 −0.011132702 −0.006824796 0.936318165 0.970026942 10029 0.04213007 0.013138143 0.265292973 0.589190565 0.0284828 −0.018540186 0.911145474 0.962221156 10031 0.075543799 0.097434874 0.609129512 0.6387822 0.367293922 −0.005472394 0.79949463 0.741412336 10033 0.026377517 0.018340861 0.095054717 0.423588199 −4.86E−04  −0.002458642 0.949741781 0.956710465 10034 0.033425663 0.02512734 0.18634948 0.60229057 0.013688821 0.013426129 0.931203298 0.947183099 10035 0.020279463 0.02175914 0.0364523 0.300278285 −0.013139777 −0.010031109 0.953667954 0.953899793 10037 0.030046405 0.021488548 0.062978323 0.313275214 0.001045534 0.001356773 0.942470588 0.956468764 10038 0.026372114 −0.001829025 0.002257233 0.024505653 −0.004964088 −0.005459318 0.934087113 0.988006397 10040 0.04965042 0.028593531 0.079753038 0.362801457 −0.003030418 −0.015363551 0.906372841 0.931478882 10041 0.041559335 0.021645254 0.072059274 0.468926949 0.01875384 0.003831169 0.914002642 0.943570199 10042 0.028059636 0.027165333 0.159310139 0.555088509 6.02E−04 0.007616406 0.939492032 0.943042626 10043 0.019282548 0.021101822 0.340209296 0.615954158 −0.004230896 −0.006153312 0.954517211 0.947644618 10045 0.010444722 0.012927694 0.233396854 0.717038532 −0.026521072 −0.031434025 0.975311721 0.969577047 10046 0.020347299 0.019610932 0.229340172 0.645899307 −0.015154296 −0.010567847 0.953309228 0.952947766 10048 0.020143973 0.015210808 0.060154171 0.495028192 0.013921412 0.010570533 0.950428781 0.969546368 10049 0.040608237 0.031604588 0.075264933 0.473617858 7.89E−04 0.004389299 0.911823381 0.92887447 10052 0.017503627 0.013801031 0.157126695 0.32081578 −0.006094217 −0.007797413 0.956909684 0.972984992 10053 0.011311864 0.015675281 0.046222991 0.305119209 −0.011028306 −0.012549685 0.972473785 0.96362138 10054 0.054953929 0.027473823 0.167679483 0.604487059 0.017146639 0.007753048 0.889998686 0.934306569 10055 0.015969118 0.017118432 0.101571797 0.302263169 −0.002832652 −0.012365396 0.960823529 0.956111373 10058 0.029763752 0.026953488 0.492045474 0.728459911 0.010215637 0.009807596 0.934421805 0.93461794 10062 0.021739726 0.016778287 0.018351097 0.420841429 5.95E−04 −0.006456804 0.955436275 0.960178593 10064 0.026595224 0.023099733 0.078911616 0.501083179 5.00E−04 0.003245918 0.945577501 0.952060007 10065 0.018600233 0.025373115 0.662967521 0.860495292 −0.003749847 −0.016334626 0.956045461 0.947290773 10069 0.013138008 0.011164596 0.068198674 0.405900722 −0.021435512 −0.05345696 0.968898951 0.978569037 10070 0.022669018 0.016251562 0.166666052 0.620378916 0.027281701 0.026450448 0.955101384 0.963042314 10072 0.026998812 0.019600661 0.100680595 0.428920697 −0.005763529 0.001426519 0.937938168 0.952942607 10073 0.032281957 0.033183973 0.030185044 0.277177537 0.0096862 0.963302857 0.928463039 0.927038173 10074 0.024875899 0.031321629 0.480037116 0.733005689 0.043781786 0.007443196 0.937417099 0.921170912 10076 0.045710899 0.028091361 0.164391319 0.455341226 0.015017479 0.009141971 0.910869299 0.940808129 10078 0.03587902 0.036731083 0.051553756 0.569544199 0.005193271 0.007651688 0.927206135 0.920553501 10079 0.012896383 0.004602465 0.445629052 0.813086048 −0.057418699 −0.009947183 0.970925699 0.996073727 10080 0.028764003 0.019558275 0.224187202 0.704488199 0.030031525 −0.024219533 0.934737136 0.95048951 10081 0.03960892 0.020360281 0.024098689 0.183163642 0.006851246 0.018016738 0.918197183 0.949680511 10082 0.03400434 0.026273852 0.028358471 0.054769895 −0.160043689 −0.015227126 0.924934536 0.945744681 10083 0.02385182 0.019988301 0.277498451 0.702136449 0.020317892 0.010942952 0.945607252 0.953371772 10084 0.009423337 0.021685821 0.224975897 0.606549884 0.018206383 0.00716612 0.970905966 0.946845445 10086 0.036625251 0.023212273 0.025188655 0.276866049 −0.109540649 −0.524623741 0.932175155 0.947470112 10087 0.024173361 0.017043544 0.044756847 0.265357348 −0.111567441 −0.048439778 0.95302088 0.964453308 10089 0.020497577 0.025572178 0.048802507 0.569068155 −0.004630295 0.004302772 0.950468211 0.941240126 10092 0.02308093 0.009447213 0.061420505 0.423262923 −1.74E−04  −0.029998471 0.95478601 0.973457274 10094 0.029986443 0.02516742 0.093868782 0.476873587 −0.017023738 −0.002700787 0.938390916 0.947052467 CFTX dV @ CFF max Patient ID CN + 75tPA CL30 CN + 150tPA CL30 CFF CL30 CFF + TXA CL30 (mm/min) 10019 0.691532258 0.013667768 0.983984265 1.018192844 0.28125 10020 0.849068323 0.102351522 1.00589198 1.015070328 0 10022 0.967101828 0.933623225 0.90119131 0.909774436 0.28125 10023 0.72179289 0.028103563 0.993456132 0.987755102 0 10024 0.019986496 0.003837609 0.933497537 0.966793893 0.28125 10026 0.658717227 0.004701734 1.001685393 0.996600567 0 10028 0.773777413 0.004587775 1.014414924 1.010477299 0 10029 0.398922273 0.00424854 0.917003419 1.042654028 0.140625 10031 0.002547771 0.003713159 0.128238767 1.015619915 0.421875 10033 0.732236753 0.125857275 1 1.012568482 0.140625 10034 0.460087083 0.007767477 0.977255497 0.978956598 0.140625 10035 0.904203178 0.145705267 1.018706157 1.016679905 0.140625 10037 0.834579439 0.129564782 0.993502475 0.994298385 0 10038 0.985962264 0.952716144 1.007125891 1.011338583 0.140625 10040 0.806022187 0.176519845 1.006355932 1.052509908 0 10041 0.799179168 0.114254144 0.950239587 0.99109462 0.140625 10042 0.521192876 0.002822865 1 0.99454347 0 10043 0.184936401 0.004690832 1.008300395 1.020230067 −0.140625 10045 0.378203049 0.004873591 1.060284678 1.070204351 −0.140625 10046 0.37218845 0.003958435 1.024469821 1.015929204 0 10048 0.82712829 0.027286649 0.96672418 0.980969642 0.140625 10049 0.805864937 0.016139141 0.992842942 0.990877498 0 10052 0.563337606 0.26097561 1.011964108 1.014350252 0 10053 0.874260541 0.198237288 1.016435707 1.02285525 0 10054 0.543710351 0.00300075 0.973808658 0.992242335 0.140625 10055 0.729655396 0.224957686 1.004087193 1.023573923 0 10058 0.015826675 0.003833253 0.976147452 0.982008996 0.140625 10062 0.957121735 0.065704067 1.011977887 1.016278327 0 10064 0.756800344 0.004366812 1.018669528 0.999329009 −6.00E−15 10065 0.002540489 0.003531229 1.005516734 1.029619182 0 10069 0.781553398 0.068803753 1.087039046 1.212637363 −0.140625 10070 0.493874539 0.003725656 0.95382526 0.947709163 0.140625 10072 0.690566499 0.006970128 1.015567087 1.001055595 −0.140625 10073 0.920555676 0.259249109 0.983117201 0.001582806 2.109375 10074 0.017798947 0.002438281 0.867339022 0.99428789 0.140625 10076 0.53002611 0.096232339 0.967523681 0.987967914 0.28125 10078 0.851969909 0.002389129 0.998309859 0.991973841 0.140625 10079 0.007710899 0.035209942 1.164487805 1.018108652 0.140625 10080 0.304102423 0.003391986 0.944753747 1.316089226 0.140625 10081 0.948804272 0.434383528 0.981234006 0.962223587 0.140625 10082 0.941184827 0.858544443 1.481165049 1.103191048 0 10083 0.251805855 0.002266289 0.961801242 0.988485694 0.140625 10084 0.3472 0.0021748 0.976790831 0.99552506 0.140625 10086 0.945094622 0.358550969 1.363609291 2.398410175 0.28125 10087 0.880506092 0.307356444 1.343873518 1.18296893 −0.140625 10089 0.835213803 0.002083062 1.024151811 0.996706012 0.140625 10092 0.8234894 0.033898305 1.048175182 1.153027523 0.140625 10094 0.704015865 0.025269318 1.058226336 1.009448819 0 CN dV @ CN + tPA75 max CRT dA Integration to Acrit CN dA Integration to Acrit Patient ID (mm/min) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10019 0.5625 31.7411499 176.0718384 10020 0.140625 24.37976074 108.4432983 10022 0.140625 8.127685547 89.33532715 10023 0.140625 146.5043335 175.1193237 10024 0.421875 7.781616211 66.48486328 10026 0.421875 83.27911377 72.15545654 10028 0.140625 14.05371094 177.543457 10029 0.84375 87.20123291 108.4235229 10031 0.984375 161.4298096 104.6365356 10033 0.421875 15.75604248 107.480896 10034 0.84375 88.0713501 91.47601318 10035 0.421875 20.97674561 93.51123047 10037 0.28125 20.60925293 194.5535889 10038 0 46.12445068 64.14477539 10040 0.28125 73.39471436 60.17816162 10041 0.421875 6.969177246 111.1772461 10042 0.421875 22.359375 139.6043701 10043 0.5625 31.41156006 120.5161743 10045 0.5625 110.9465332 121.7636719 10046 0.28125 4.541748047 76.05780029 10048 0.28125 105.1243286 179.8571777 10049 0.28125 130.3511353 96.63244629 10052 0.28125 80.39025879 158.8392334 10053 0.140625 19.06677246 161.8994751 10054 0.421875 106.6256104 81.1038208 10055 0.28125 76.30169678 120.0481567 10058 0.703125 27.76794434 110.1373901 10062 0.140625 10.21893311 93.27392578 10064 0.140625 78.70770264 116.4210205 10065 1.265625 41.66015625 77.69421387 10069 0.140625 47.99816895 197.9401245 10070 0.421875 11.39886475 91.3392334 10072 0.28125 169.7272339 128.9833374 10073 0 266.918335 257.6453247 10074 0.703125 13.6137085 120.9594727 10076 0.5625 42.14959717 142.8343506 10078 0.28125 104.5129395 177.0441284 10079 0.5625 40.72576904 186.0320435 10080 0.984375 80.52703857 36.67181396 10081 0.140625 273.0470581 143.079895 10082 0.140625 28.32495117 68.89086914 10083 0.28125 34.64154053 100.2694702 10084 0.140625 100.7177124 178.5157471 10086 0.140625 128.4246826 100.1524658 10087 0.28125 138.6172485 140.5206299 10089 0.140625 53.89782715 196.9431152 10092 0.28125 155.1560669 153.1142578 10094 0.703125 41.04217529 112.9405518 CN + 75tPA dA Integration to Acrit CN + 150tPA dA Integration to Acrit CFF dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10019 131.9265747 77.90844727 14.46240234 10020 107.7000732 88.54925537 21.88970947 10022 71.53582764 119.2175903 8.803344727 10023 96.00292969 48.77600098 45.24279785 10024 171.0027466 99.48999023 17.62646484 10026 69.8104248 50.5178833 0.278503418 10028 192.3255615 163.6281738 24.4588623 10029 49.97900391 52.5201416 30.09979248 10031 95.62884521 86.88647461 1.105773926 10033 101.4098511 85.96856689 42.42150879 10034 77.46844482 49.8883667 3.371704102 10035 68.41296387 68.36846924 34.21307373 10037 209.1115723 169.8145752 34.14385986 10038 73.65673828 75.53210449 30.17559814 10040 37.54193115 100.8495483 53.66217041 10041 30.91552734 69.57476807 18.02032471 10042 149.2036743 113.6920166 24.84283447 10043 126.173584 105.0518188 29.10772705 10045 73.59741211 55.30517578 70.72998047 10046 48.24041748 76.40222168 7.864013672 10048 184.911438 147.2590942 56.56915283 10049 91.41833496 94.50164795 16.1416626 10052 190.2095947 46.33209229 34.28393555 10053 101.8580933 103.1022949 20.61584473 10054 66.59692383 82.92810059 15.07543945 10055 55.00360107 129.8139038 59.88153076 10058 89.20019531 79.67834473 26.85992432 10062 81.41363525 100.6468506 23.73046875 10064 205.6195679 207.8245239 56.35821533 10065 48.6260376 74.17749023 31.25335693 10069 188.4710083 182.1873779 48.08880615 10070 58.20062256 104.883728 8.679748535 10072 158.1075439 152.0348511 17.0859375 10073 311.8677979 98.69732666 62.96813965 10074 96.13311768 108.487793 11.56365967 10076 103.7120361 111.0997925 26.94232178 10078 124.2784424 139.541748 59.2701416 10079 230.6552124 201.6463623 238.847168 10080 79.13616943 87.91644287 15.51708984 10081 147.1552734 149.0718384 61.43225098 10082 87.04962158 64.06237793 18.13897705 10083 137.142334 149.5794067 38.19287109 10084 151.3707275 155.8811646 42.3951416 10086 110.9432373 68.44262695 35.31884766 10087 191.46698 111.8084106 32.47283936 10089 151.2372437 114.6115723 50.00042725 10092 148.8806763 155.2236328 14.43109131 10094 119.8833618 155.0736694 54.3147583 CFF + TXA dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) ID SBP HR OR? ICU? Death? pRBC FFP PLT CRYO CN Crit Prod 10019 28.41064453 10019 86 90 Yes Yes No 0 0 0 0 19.26974487 10020 22.59503174 10020 136 100 Yes 0 No 0 0 0 0 14.20358276 10022 6.862060547 10022 138 88 No Yes No 0 0 0 0 10.35644531 10023 76.33795166 10023 106 120 Yes 0 No 0 0 0 0 19.7460022 10024 8.737426758 10024 150 108 Yes Yes No 0 0 0 0 7.946777344 10026 1.496337891 10026 116 100 Yes Yes No 0 0 1 0 8.667755127 10028 26.37213135 10028 102 100 No Yes No 0 0 0 0 20.61035156 10029 31.25994873 10029 62 120 Yes Yes No 0 0 0 0 11.96841431 10031 15.78076172 10031 Uto Uto Yes Yes No 0 0 0 0 13.73080444 10033 34.27734375 10033 110 94 Yes Yes No 0 0 0 0 12.02883911 10034 7.218017578 10034 140 100 Yes Yes No 0 0 0 0 10.41732788 10035 14.93206787 10035 80 70 Yes Yes No 0 0 0 0 10.71533203 10037 33.68243408 10037 180 120 No Yes No 0 0 0 0 21.703125 10038 40.28082275 10038 128 120 Yes Yes No 0 0 0 0 8.049316406 10040 27.57348633 10040 162 108 No 0 No 0 0 0 0 7.882781982 10041 15.65222168 10041 88 70 Yes Yes No 0 2 1 0 13.16894531 10042 19.11621094 10042 100 90 Yes Yes No 0 0 0 0 14.67919922 10043 26.66546631 10043 90 60 Yes Yes No 0 0 0 0 14.03640747 10045 37.99841309 10045 100 58 No Yes Yes 0 0 0 0 13.68823242 10046 5.115234375 10046 130 90 No 0 No 0 0 0 0 8.567230225 10048 80.21722412 10048 88 112 No 0 No 0 0 0 0 24.58374023 10049 9.149414062 10049 Walk-in Walk-in No 0 No 0 0 0 0 10.72998047 10052 21.70184326 10052 100 100 Yes Yes No 0 0 0 0 18.51928711 10053 28.09588623 10053 116 110 Yes Yes No 0 0 0 0 16.95803833 10054 13.2989502 10054 108 124 Yes Yes No 0 0 0 0 9.368865967 10055 55.71386719 10055 136 78 No Yes No 0 0 0 0 14.01158823 10058 11.59661865 10058 118 110 Yes Yes No 0 0 0 0 12.33078003 10062 25.08178711 10062 86 60 No 0 No 0 0 0 0 11.54846191 10064 51.12597656 10064 118 72 No 0 No 0 0 0 0 17.66125488 10065 38.93609619 10065 140 120 No Yes No 0 0 0 0 9.33984375 10069 39.92816162 10069 90 140 Yes Yes No 0 0 0 0 22.54550171 10070 20.0291748 10070 160 92 Yes 0 No 0 0 0 0 9.743774414 10072 14.16412354 10072 Unk Unk No 0 No 0 0 0 0 14.2215271 10073 963.953064 10073 156 114 Yes Yes No 0 0 0 0 29.18106079 10074 13.36651611 10074 81 100 Yes Yes No 0 0 0 0 13.63476563 10076 20.18408203 10076 170 60 Yes Yes No 0 0 1 0 16.8182373 10078 55.34472656 10078 96 60 Yes Yes No 0 0 0 0 22.06704712 10079 49.64117432 10079 82 112 No Yes No 0 0 0 0 21.89071655 10080 96.45941162 10080 98 112 No 0 No 0 0 0 0 6.192718506 10081 24.95159912 10081 Walk-in Walk-in Yes Yes No 0 0 0 0 16.8296814 10082 11.51916504 10082 138 120 No 0 No 0 0 0 0 7.883422852 10083 19.47052002 10083 142 70 Yes Yes No 0 0 0 0 11.49032593 10084 29.05499268 10084 170 104 No Yes No 0 0 0 0 18.54931641 10086 18.47186279 10086 100 120 Yes 0 No 0 0 0 0 12.44750977 10087 53.8895874 10087 162 120 No 0 No 0 0 0 0 15.19042969 10089 125.1551514 10089 120 80 Yes Yes No 0 0 0 0 27.10473633 10092 20.99981689 10092 210 128 No 0 No 0 0 0 0 15.80556406 10094 50.6184082 10094 128 100 Yes Yes No 0 0 0 0 14.43154063 Patient ID 10019 10020 10022 10023 10024 10026 10028 10029 10031 10033 10034 10035 10037 10038 10040 10041 10042 10043 10045 10046 10048 10049 10052 10053 10054 10055 10058 10062 10064 10065 10069 10070 10072 10073 10074 10076 10078 10079 10080 10081 10082 10083 10084 10086 10087 10089 10092 10094 CRT Amax CN Amax CN + 75tPA Amax CN + 150tPA Amax CFF Amax CFF + TXA Amax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10096 63.640625 65.1875 64.7421875 65.1875 24.6171875 24.8984375 10098 59.703125 66.171875 62.5625 61.625 19.296875 19.953125 10100 66.734375 71.65625 67.6015625 54.125 26.0703125 26.65625 10101 63.0546875 66.6640625 64.1328125 55.25 24.3359375 24.3359375 10103 66.4296875 68.46875 63.7109375 46.484375 28.390625 26.65625 10105 56.7734375 60.4296875 62.140625 52.203125 26.5625 24.5 10108 52.2265625 65.375 58.765625 59 20.2578125 18.734375 10109 62.8671875 66.3828125 63.546875 58.8359375 24.359375 24.0546875 10110 65.84375 64.15625 66.78125 65.5625 22.7890625 21.9921875 10111 67.6015625 73.5078125 71.1875 68.6796875 26.6328125 26.65625 10112 82.1328125 62.5625 60.03125 54.4765625 29.2578125 0.125 10113 50.3046875 48.125 28.6015625 23.5625 15.9921875 14.65625 CRT Acrit CN Arit CN + 75tPA Acrit CN + 150tPA Acrit CFF Acrit CFF + TXA Acrit Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10096 18.40625 16.15625 13.9765625 13.75390625 3.67578125 4.71875 10098 1.84765625 6.41796875 7.09765625 8.19921875 1.56640625 2.19921875 10100 2.29296875 13.15625 16.82421875 16.765625 4.390625 5.7734375 10101 2.1640625 10.1796875 10.4609375 8.78515625 4.109375 3.91015625 10103 10.51953125 11.26953125 9.9453125 8.38671875 4.4375 27.875 10105 1.84765625 14.328125 15.18359375 12.8515625 5.609375 4.96484375 10108 1.35546875 9.640625 10.15625 8.3515625 1.390625 2.0703125 10109 2.66796875 14.10546875 9.7578125 10.49609375 2.92578125 3.72265625 10110 1.6953125 11.41015625 9.41796875 10.2734375 3.546875 3.359375 10111 15.5703125 13.90625 11.8203125 14.84375 4.578125 4.89453125 10112 11.8203125 19.7890625 17.75 16.6953125 5.65625 0.16015625 10113 11.375 14.57421875 12.0546875 0.359375 11.22265625 1.7890625 CRT dAmax CN dAmax CN + 75tPA dAmax CN + 150tPA dAmax CFF dAmax CFF + TXA dAmax Patient ID (mm) (mm) (mm) (mm) (mm) (mm) 10096 0.984375 1.03125 1.03125 1.1015625 0.5390625 0.609375 10098 1.1953125 1.4296875 1.3359375 1.2421875 0.5390625 0.3984375 10100 1.7578125 1.265625 1.0078125 0.984375 0.65625 0.703125 10101 1.40525 1.453125 1.359375 1.3828125 0.9375 0.8203125 10103 1.3828125 1.4296875 1.3125 0.7265625 1.125 1.921875 10105 1.6640625 0.9375 1.2421875 1.453125 0.75 0.6796875 10108 0.9140625 1.3125 1.359375 1.5 0.65625 0.375 10109 1.8515625 1.1953125 1.640625 1.3828125 0.8203125 0.7265625 10110 1.828125 1.0546875 1.3359375 1.40625 0.84375 0.75 10111 1.78125 1.734375 1.734375 1.96875 1.078125 0.8203125 10112 3.84375 0.75 0.5625 0.84375 0.890625 0.0703125 10113 0.703125 0.3515625 0.234375 0.46875 4.1015625 0.28125 CN + 75tPA CN + 150tPA CFF + TXA Patient ID CRT LY30 CN LY30 LY30 LY30 CFF LY30 LY30 CRT CL30 CN CL30 10096 0.02673739 0.023091276 0.022254736 0.04494031 0.002878275 −8.86E−04 0.94254849 0.94822627 10098 0.028060208 0.025009675 0.019210477 0.024390248 −0.011732456 −0.002473245 0.940722324 0.950413223 10100 0.032283943 0.019990945 0.064302843 0.563915151 −0.011968085 −0.023366468 0.93889019 0.960423027 10101 0.023396867 0.017267276 0.079153977 0.54122007 −0.005733012 −0.005837346 0.953537356 0.957810852 10103 0.019735192 0.020560912 0.068618434 0.441085434 0.011639684 −9.79E−04 0.955545102 0.951049749 10105 0.0298312 0.028208719 0.241447525 0.672740198 0.004960784 −0.00922619 0.934773634 0.940271493 10108 0.021454126 0.024958008 0.562259963 0.618193856 0.022240969 0.017528496 0.949289454 0.946223709 10109 0.022353396 0.012313169 0.035683892 0.524804696 −0.006783194 −2.86E−04 0.955635641 0.967517948 10110 0.022358013 0.020903184 0.021046184 0.180870505 0.016776178 0.009773535 0.940199336 0.954335119 10111 0.022739705 0.01260451 0.021232989 0.247648005 −0.016114207 −0.018321366 0.955622328 0.96779679 10112 0.879012492 0.027216533 0.072425928 0.479522205 0.002217401 0 0.001807286 0.932567433 10113 0.046618911 0.009909361 0.266667805 0.752061229 0.024084025 0.009252843 0.902624631 0.960064935 CFTX dV @ CFF max Patient ID CN + 75tPA CL30 CN + 150tPA CL30 CFF CL30 CFF + TXA CL30 (mm/min) 10096 0.946060094 0.883149569 1.012377023 1.001882648 0.140625 10098 0.95467033 0.951698783 1.025506073 1.002349256 −0.140625 10100 0.812434994 0.002742494 1.042253521 1.110785463 0 10101 0.764648556 0.003959275 1.013483146 1.009630819 0.140625 10103 0.800613121 0.050084034 0.987616951 1.175849941 0.140625 10105 0.317701785 0.002394493 0.990294118 1.015306122 0.140625 10108 0.002127094 0.002118644 0.952564597 0.962468724 0.140625 10109 0.890828621 0.002124552 1.011545863 1.000974342 −0.140625 10110 0.955077211 0.406577693 0.977374014 0.988277087 0.28125 10111 0.955553117 0.240700717 1.036960986 1.055392732 0 10112 0.805960437 0.014771261 0.999198932 1 0 10113 0.328871893 0.00530504 0.935515388 0.984008529 −0.140625 CN dV @ CN + tPA75 max CRT dA Integration to Acrit CN dA Integration to Acrit Patient ID (mm/min) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10096 0.28125 137.9168701 152.5968018 10098 0.140625 18.10931396 85.04241943 10100 0.28125 30.77545166 142.5476074 10101 0.28125 24.70935059 126.7272949 10103 0.140625 148.2346802 139.7114868 10105 0.28125 21.95892334 119.911377 10108 0.703125 9.876159668 112.7658691 10109 0.140625 41.13446045 152.0645142 10110 0.140625 19.80834961 116.5907593 10111 0.140625 248.6063232 218.4060059 10112 0.140625 332.9483643 130.4747314 10113 0.5625 74.6619873 36.29608154 CN + 75tPA dA Integration to Acrit CN + 150tPA dA Integration to Acrit CFF dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) (mm{circumflex over ( )}2) 10096 114.3511963 138.5315552 17.31170654 10098 88.23614502 99.55096436 6.07598877 10100 103.4598999 133.3125 24.56433105 10101 113.6920166 106.6964722 35.62536621 10103 101.5993652 47.87127686 44.81103516 10105 157.7796021 169.5179443 29.953125 10108 135.2076416 114.6643066 8.041992187 10109 124.2454834 133.0438843 18.23126221 10110 93.62493896 127.8973389 25.58605957 10111 173.4334717 267.8873291 41.30090332 10112 66.29699707 118.8896484 39.0135498 10113 14.78869629 0.046142578 11.96575928 CFF + TXA dA Integration to Acrit Patient ID (mm{circumflex over ( )}2) ID SBP HR OR? ICU? Death? pRBC FFP PLT CRYO CN Crit Prod 10096 22.05615234 10096 100 96 Yes Yes No 0 0 0 0 16.66113281 10098 8.37322998 10098 108 112 No Yes No 0 0 0 0 9.175689697 10100 35.33862305 10100 Unk Unk Yes 0 No 0 0 0 0 16.65087891 10101 27.97064209 10101 110 110 Yes 0 No 0 0 0 0 14.7923584 10103 134.5023193 10103 123 92 No 0 No 0 0 0 0 16.11190796 10105 20.06707764 10105 0 0 Yes Yes No 0 0 0 0 13.43261719 10108 7.827758789 10108 150 90 No Yes No 0 0 0 0 12.65332031 10109 18.26751709 10109 92 110 Yes Yes No 0 2 0 0 16.86044312 10110 21.515625 10110 100 92 Yes Yes No 0 0 0 0 12.03414917 10111 29.56256104 10111 115 70 No Yes No 0 0 0 0 24.11865234 10112 0.014831543 10112 210 142 No Yes No 0 0 0 0 14.84179688 10113 3.978149414 10113 110 110 No Yes No 0 0 0 0 5.123748779 Patient ID 10096 10098 10100 10101 10103 10105 10108 10109 10110 10111 10112 10113 

1. An in vitro method for identifying a patient as requiring a transfusion of at least six units of blood in six hours or less, the method comprising (a) analyzing a sample of blood from the patient with a viscoelastic analysis assay to obtain a patient coagulation characteristic value that is independent of time, wherein the patient coagulation characteristic value is lower than a control coagulation characteristic value that is independent of time; and (b) identifying the patient as requiring a transfusion of at least six units of blood in six hours or less.
 2. The method of claim 1, wherein the control coagulation characteristic value is obtained by analyzing a sample of blood from a control with a viscoelastic analysis assay.
 3. The method of claim 2, wherein the control is a healthy volunteer.
 4. The method of claim 2, wherein the control is a population of patients and the control coagulation characteristic value is the mean coagulation characteristic value of the population.
 5. The method of claim 1, wherein the sample of blood is not supplemented with a clotting factor or an enhancer of clot formation.
 6. The method of claim 1, wherein the patient or control coagulation characteristic value is Acrit,
 7. The method of claim 1, wherein the patient or control coagulation characteristic value is dAmax,
 8. The method of claim 1, wherein the patient coagulation characteristic value is obtained not more than twenty minutes after the start of the viscoelastic analysis of the sample of blood from the patient.
 9. The method of claim 1, wherein the patient coagulation characteristic value is obtained not more than fifteen minutes after the start of the viscoelastic analysis of the sample of blood from the patient.
 10. (canceled)
 11. The method of claim 1, wherein the patient coagulation characteristic value is obtained not more than five minutes after the start of the viscoelastic analysis of the sample of blood from the patient.
 12. The method of claim 1, wherein the patient coagulation characteristic value is obtained not more than fifteen minutes after the start of clot formation in the sample of blood from the patient.
 13. (canceled)
 14. The method of claim 1, wherein the patient coagulation characteristic value is obtained not more than five minutes after the start of clot formation in the sample of blood from the patient.
 15. (canceled)
 16. (canceled)
 17. The method of claim 1, wherein the viscoelastic assay is performed using a thromboelastography analyzer system.
 18. The method of claim 1, wherein the viscoelastic assay is performed using a thromboelastometry analyzer system.
 19. The method of claim 1, wherein the patient coagulation characteristic value is at least 1.5 times lower than the control coagulation characteristic value.
 20. The method of claim 1, wherein identifying comprises identifying the patient as requiring a transfusion of at least ten units of blood in six hours or less.
 21. The method of claim 1, wherein the patient coagulation characteristic value is obtained by fitting a tracing from the viscoelastic analysis assay of the same sample of blood from the patient to a tracing from the model dA/dT=aA2/(ebA−1).
 22. The method of claim 1, wherein the patient coagulation characteristic value is obtained by taking an area under a tracing from the viscoelastic analysis assay of the same sample of blood from the patient from a start of clot formation to a maximum amplitude.
 23. An in vitro method for determining an amount of fibrinogen in a patient comprising: (a) analyzing a sample of blood from a patient with a viscoelastic analysis assay to obtain a patient coagulation characteristic value that is independent of time and (b) plotting the patient coagulation characteristic value against a standard table of coagulation characteristic values of blood samples of healthy volunteers with known amounts of fibrinogen to determine the amount of fibrinogen in the sample of blood from the patient.
 24. (canceled)
 25. (canceled)
 26. An in vitro method for determining a quantity of platelets in a patient comprising: (a) analyzing a sample of blood from a patient with a viscoelastic analysis assay to obtain a patient coagulation characteristic value that is independent of time and (b) plotting the patient coagulation characteristic value against a standard table of coagulation characteristic values of blood samples of healthy volunteers with known quantities of platelets to determine the quantity of platelets in the sample of blood from the patient.
 27. (canceled)
 28. (canceled) 